Summary
A behavioral study was performed in an attempt to understand the neuronal mechanisms involved in yawning and ‘Wet-Dog’ body shaking in rats.
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1.
Physostigmine (0.2 mg/kg, i. p.) and pilocarpine (4 mg/kg, i. p.) induced yawning. The physostigmine-induced yawning was markedly inhibited by high doses (4, 8 mg/kg, i. p.) of apomorphine which preferentially stimulate postsynaptic dopamine receptors but was not inhibited by methysergide, whereas the pilocarpine-induced yawning was unaffected by either apomorphine or methysergide.
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2.
Intraperitoneal injections of low doses (5 mg/kg, i. p.) of piribedil, which preferentially activate presynaptic dopamine autoreceptors, also elicited yawning. At a high dose of 80 mg/kg, piribedil produces stereotypy which has been thought to be mediated by stimulation of postsynaptic dopamine receptors. The yawning and stereotypy did not occur simultaneously in the rat. The piribedil-induced yawning was markedly inhibited after treatment with fluphenazine, scopolamine or methysergide.
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3.
Intraventricular injection of α-melanocyte-stimulating hormone (α-MSH, 10 μg/rat) elicited not only yawningstretching syndrome but also ‘Wet-Dog’ body shaking. Yawning synchronized with stretching in almost all cases. The α-MSH-induced yawning-stretching syndrome was blocked by scopolamine, apomorphine (8 mg/kg×3, i. p.), fluphenazine or methysergide, while body shaking was inhibited by methysergide, apomorphine or fluphenazine but was not inhibited by scopolamine.
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4.
Body shaking was also produced by 5-hydroxytryptophan (150 mg/kg, s. c.) in combination with a peripheral decarboxylase inhibitor, Ro 4-4602 (50 mg/kg, i. p.), accompanied rarely by yawning and stretching.
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5.
The present results indicate that a reciprocal balance of serotonergic activation-dopaminergic inhibition-cholinergic activation is involved in the yawning, and that α-MSH also induces body shaking by activating in part the central serotonergic neuron system.
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References
Baldwin DM, Haun CK, Sawyer CH (1974) Effects of intraventricular infusions of ACTH1–24 and ACTH4–10 on LH release, ovulation and behavior in the rabbit. Brain Res 80:291–301
Bedard P, Pycock CJ (1977) ‘Wet-Dog’ shake behavior in the rat: A possible quantitative model of central 5-hydroxytryptamine activity. Neuropharmacology 16:663–670
Biscoe TJ, Straughan DW (1966) Microelectrophoretic studies of neurones in the cat hippocampus. J Physiol (Lond) 183:341–359
Carlsson A (1975) Receptor-mediated control of dopamine metabolism. In: Usdin E, Bunny WE (eds) Pre- and postsynaptic receptors. Marcel Dekker, New York, p 49
Carter CJ, Pycock CJ (1978) A study of the sites of interaction between dopamine and 5-hydroxytryptamine for the production of fluphenazine-induced catalepsy. Naunyn-Schmiedeberg's Arch Pharmacol 304:135–139
Choi RL, Roth RH (1978) Development of supersensitivity of apomorphine-induced increase in acetylcholine levels and stereotypy after chronic fluphenazine treatment. Neuropharmacology 17:59–64
Cools A, Van Rossum JM (1976) Excitation-mediating and inhibition-mediating dopamine-receptors: A new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data. Psychopharmacologia 45:243–254
Costall B, Naylor RJ (1973a) oN the mode of action of apomorphine. Eur J Pharmacol 21:350–361
Costall B, Naylor RJ (1973b) The site and mode of action of ET-495 for the mediation of stereotyped behaviour in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 278:117–133
Douglas WW (1975) Histamine and antihistamines; 5-hydroxytryptamine and antagonists. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, p 590
Ferrari W, Gessa GL, Vargiu L (1963) Behavioral effects induced by intracisternally injected ACTH and MSH. Ann NY Acad Sci 104:330–345
Fozard JR, Palfreyman MG (1979) Metoclopramide antagonism of 5-hydroxytryptophan-induced ‘Wet-dog’ shake behavior in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 307:135–142
Furukawa T, Yamada K (1980) The α-naphthoxyacetic acid-elicited retching involves dopaminergic inhibition in mice. Pharmacol Biochem Behav 12:735–738
Fuxe K (1965) The distribution of monoamine terminals in the central nervous system. Acta Physiol Scand 64 Suppl 247:41–85
Gessa GL, Vargiu L, Ferrari W (1966) Stretching and yawnings induced by adrenocorticotrophic hormone. Nature 211:426–427
Gispen WH, Wiegant VM, Greven HM, De Wied D (1975) The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: Structure-activity studies. Life Sci 17:645–652
Groves PM, Wilson CJ, Young SJ, Rebec GV (1975) Self-inhibition by dopaminergic neurons: An alternative to the “neuronal feed back loop” hypothesis for the mode of action of certain psychotropic drugs. Science 190:522–529
Himmelsbach CK (1939) Studies of certain addiction characteristics of (a) dihydromorphine (“paramorphan”), (b) dihydrodesoxymorphine-D (“desomorphine”), (c) dihydrodesoxycodeine-D (“desocodeine”), and (d) methyldihydromorphinone (“metopon”). J Pharmacol Exp Ther 67:239–249
Innes IR, Nickerson M (1975) Atropine, scopolamine, and related antimuscarinic drugs. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, p 514
Kataoka A, Kóriyama T, Arimura K, Enatsu M, Igata A, Tokito S (1980) Adrenoleukodystrophy and yawning. Autonomic Nervous System 17:24–25
Ladinsky H, Consolo S, Garattini S (1974) Increase in striatal acetylcholine levels in vivo by piribedil, a new dopamine receptor stimulant. Life Sci 14:1251–1260
Lal H, Numan R (1976) Blockade of morphine-withdrawal body shakes by haloperidol. Life Sci 18:163–168
Nicolaou NM, Garcia-Munoz M, Arbuthnott GW, Eccleston D (1979) Interactions between serotonergic and dopaminergic systems in rat brain demonstrated by small unilateral lesions of the raphe nuclei. Eur J Pharmacol 57:295–305
Nowycky MC, Roth RH (1977) Presynaptic dopamine receptors: Development of supersensitivity following treatment with fluphenazine decanoate. Naunyn-Schmiedeberg's Arch Pharmacol 300:247–254
Pellegrino LJ, Pellegrino AS, Cushmann AJ (1979) A sterotaxic atlas of the rat brain. Plenum Press, New York
Prange AJ Jr, Wilson IC, Lara PP, Alltop LB, Breese GR (1972) Effects of thyrotropin-releasing hormone in depression. Lancet II:999–1002
Rees HD, Dunn AJ, Iuvone PM (1976) Behavioral and biochemical responses of mice to the intraventricular administration of ACTH analogs and lysine vasopressin. Life Sci 18:1333–1340
Robinson S, Cheney DL, Moroni F, Costa E (1978) Acetylcholine turnover in specific brain areas of rats injected with various antidepressants. In: Garrattini S (ed) Depressive disorders. Schattauer Verlag, Berlin, p 129
Robinson SE, Malthe-Sørenssen D, Wood PL, Comissiong J (1979) Dopaminergic control of the septal-hippocampal cholinergic pathway. J Pharmacol Exp Ther 208:476–479
Rommelspacher H, Kuhar MJ (1974) Effects of electrical stimulation on acetylcholine levels in central cholinergic nerve terminals. Brain Res 81:243–251
Seevers MH (1936) Opiate addiction in the monkey. I. Methods of study. J Pharmacol Exp Ther 56:147–156
Siegel S (1956) Nonparametric statistics for the behavioral sciences. McGraw-Hill, Tokyo
Storm-Mathisen J (1970) Quantitative histochemistry of acetylcholinesterase in rat hippocampal region correlated to histochemical staining. J Neurochem 17:739–750
Strömbom U (1976) Catecholamine receptor agonists. Naunyn-Schmiedeberg's Arch Pharmacol 292:167–176
Urbá-Holmgren R, Gonzalez RM, Holmgren B (1977) Is yawing a cholinergic response? Nature 267:261–262
Walters J, Roth R (1976) Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors. Naunyn-Schmiedeberg's Arch Pharmacol 296:5–14
Wei E, Sigel S, Loh H, Way EL (1975) Thyrotropin-releasing hormone and shaking behavior in rat. Nature 253:739–740
Wood PL, Cheney DL, Costa E (1979) Modulation of the turnover rate of hippocampal acetylcholine by neuropeptides: Possible site of action of α-melanocyte-stimulating hormone, adrenocorticotrophic hormone and somatostatin. J Pharmacol Exp Ther 209:97–103
Yamada K, Furukawa T (1980a) Direct evidence for involvement of dopaminergic inhibition and cholinergic activation in yawning. Psychopharmacology 67:39–43
Yamada K, Furukawa T (1980b) Dopaminergic inhibition involved in the α-naphthoxyacetic acid-induced jumping behavior in mice. Eur J Pharmacol 63:321–325
Yamada K, Furukawa T (1980c) Behavior of rats and mice administered active metabolites of fluphenazine, 7-hydroxy-fluphenazine and fluphenazine-sulfoxide. Arch Int Pharmacodyn Ther (in press)
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Yamada, K., Furukawa, T. The yawning elicited by α-melanocyte-stimulating hormone involves serotonergic-dopaminergic-cholinergic neuron link in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 316, 155–160 (1981). https://doi.org/10.1007/BF00505310
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DOI: https://doi.org/10.1007/BF00505310