Summary
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1.
The effect of capsaicin injected into the superior mesenteric artery has been studied on the intestinal blood flow in dogs.
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2.
Capsaicin evoked a marked dose-dependent increase in mesenterial blood flow in the dose range of 0.1–7 μg/kg. The intestinal vasodilatatory effect of capsaicin could invariably be demonstrated after pretreatment with adrenoceptor and dopamine receptor antagonists, as well as with the ganglion blocking agent hexamethonium.
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3.
Pretreatment with atropine significantly reduced, but did not abolish the increase in intestinal blood flow elicited by capsaicin.
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4.
Concomitant administration of somatostatin significantly inhibited both the atropine-sensitive and the atropineresistant components of the effect of capsaicin injected into the superior mesenteric artery.
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5.
Our results indirectly support the assumption that the intestinal vasodilatatory effect of capsaicin may be mediated by substance P release from capsaicin-sensitive paravascular nerve fibres associated with the blood vessels of the gastrointestinal tract. It is suggested that sensory substance P-containing nerve fibres may be involved in the regulation of the vascular reactions of the gut.
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Rózsa, Z., Jancsó, G. & Varró, V. Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog. Naunyn-Schmiedeberg's Arch. Pharmacol. 326, 352–356 (1984). https://doi.org/10.1007/BF00501442
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DOI: https://doi.org/10.1007/BF00501442