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Bacterial hemolysins as virulence factors

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References

  1. Mackaness, GB: Cellular resistance to infections. J. Exp. Med. 116, 381–406 (1962)

    Google Scholar 

  2. Wagner, W, Vogel, M and Goebel, W: Transport of hemolysin across the outer membrane of E. coli requires two functions. J. Bact. 154, 200–210 (1983)

    Google Scholar 

  3. Hess, J, Wels, W, Vogel, M and Goebel, W: Nucleotide sequence of a plasmid-encoded hemolysin determinant and its comparison with a corresponding chromosomal hemolysin sequence. FEMS Microbiol. Letts. 34, 1–11 (1986)

    Google Scholar 

  4. Felmlee, T, Pellet, S and Welch, RA: Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J. Bact. 163, 94–105 (1985)

    Google Scholar 

  5. Noegel, A, Rdest, U and Goebel, W: Determination of the functions of hemolytic plasmid pHly 152 of Escherichia coli. J. Bact. 145, 233–247 (1981)

    Google Scholar 

  6. Knapp, S, Hacker, J, Jarchau, T and Goebel, W: Large, unstable inserts in the chromosome affect virulence properties of uropathogenic E. coli 06 strain 536. J. Bact. 168, 22–30 (1986)

    Google Scholar 

  7. Müller, G, Hughes, C and Goebel, W: Relationship between plasmid and chromosomal hemolysin determinants of E. coli. J. Bact. 153, 846–851 (1983)

    Google Scholar 

  8. Koronakis, V, Cross, M, Senor, B, Koronakis, E and Hughes, C: The secreted hemolysins of Proteins mirabilis, Proteus vulgaris and Morganella morganii are genetically related to each other and to the alpha-hemolysin of E. coli. J. Bact. 169, 1509–1515 (1987)

    Google Scholar 

  9. Welch, RA: Identification of two different hemolysin determinants in uropathogenic Proteus isolates. Infect. Immun. 55, 2183–2190 (1987)

    Google Scholar 

  10. Strathdee, CA and Lo, RYC: Extensive homology between the leukotoxin of Pasteurella haemolytica A1 and the alpha-hemolysin of E. coli. Infect. Immun. 55, 3233–3236 (1987)

    Google Scholar 

  11. Welch RA and Pellett S: Transcriptional organization of the E. coli hemolysin genes. J. Bact. 1622–1630 (1988)

  12. Vogel, M, Hess, J, Then, I, Juarez, A and Goebel, W: Characterization of a sequence (hlyR) which enhances synthesis and secretion of hemolysin in E. coli. Mol. Gen. Genet. 212, 76–84 (1988)

    Google Scholar 

  13. Chakraborty, T, Huhle, B, Bergbauer, H and Goebel, W: Cloning, expression, and mapping of the Aeromonas hydrophila aerolysin gene determinant in E. coli K-12. J. Bact. 167, 368–374 (1986)

    Google Scholar 

  14. Husslein V, Huhle B, Jarchau T, Lurz R, Goebel W and Chakraborty T: Nucleotide sequence and transcriptional analysis of the aerC aerA region of Aeromonas sobria encoding aerolysin and its regulatory region. Molec. Microbiol. 2, (in press)

  15. Mengaud, J, Vicente, M-F, Chenevert, J, Peiveira, JM, Geoffrey, C, Gicquel-Sanzey, B, Baquereo, F, Perez-Diaz, J-C and Cossart, P: Expression in E. coli and sequence analysis of the listeriolysin 0 determinant of Listeria monocytogenes. Infect. Immun. 56, 766–772 (1988)

    Google Scholar 

  16. Goebel, W, Kathariou, S, Kuhn, M, Sokolovic, Z, Kreft, J, Köhler, S, Funke, D, Chakraborty, T and Leimeister-Wächter, M: Hemolysin from Listeria—biochemistry, genetics and function in pathogenesis. Infection 16, 149–156 (1988)

    Google Scholar 

  17. Kathariou, S, Metz, P, Hof, H and Goebel, W: Tn916-induced mutations in the hemolysin determinants affecting virulence of Listeria monocytogenes. J. Bact. 169, 1291–1297 (1987)

    Google Scholar 

  18. Gaillard, JL, Berche, P and Sansonetti, P: Transposon mutagenesis as a tool to study the role of haemolysins in virulence of Listeria monocytogenes. Infect. Immun. 52, 50–55 (1986)

    Google Scholar 

  19. Härtlein, M, Schießl, S, Wagner, W, Rdest, U, Kreft, J and Goebel, W: Transport of hemolysin by E. coli. J. Cell. Biochem. 22, 87–97 (1983)

    Google Scholar 

  20. Wagner, W, Kuhn, M and Goebel, W: Active and inactive forms of hemolysin (HlyA) from E. coli. Biol. Chem. Hoppe-Seyler 369, 39–46 (1988)

    Google Scholar 

  21. Ludwig A, Jarchau T, Benz R and Goebel W: The repeat domain of E. coli haemolysin (HLyA) is responsible for its Ca2+-dependent binding to erythrocytes. Mol. Gen. Genet. (in press)

  22. Erb, K, Vogel, M, Wagner, W and Goebel, W: Alkaline phosphatase which lacks its own signal sequence becomes enzymatically active when fused to N-terminal sequences of E. coli haemolysin (HlyA). Mol. Gen. Genet. 208, 88–93 (1987)

    Google Scholar 

  23. Hacker, J, Hof, H, Emödy, H and Goebel, W: Influence of cloned E. coli hemolysin genes, S-fimbriae and serum resistance on pathogenicity in different animal models. Microbial. Pathogen. 1, 533–547 (1986)

    Google Scholar 

  24. Hacker, J, Hof, H, Emödy, L and Goebel, W: Clones hemolysin genes from E. coli that cause urinary tract infection determine different levels of toxicity in mice. Infect. Immun. 42, 57–63 (1983)

    Google Scholar 

  25. Goebel, W, Kathariou, S, Hacker, W, Chakraborty, T, Leimeister-Wächter, M, Ludwig, A, Hess, J, Kuhn, M and Wagner, W: Bacterial cytolysins as virulence factors, in Fehrenbach et al. (Eds.) Bacterial Protein Toxins, Zbl. Bakt. Suppl. 325–335, Gustav-Fischer, Stuttgart, New York, 1988

    Google Scholar 

  26. König, B, König, W, Scheffer, J, Hacker, J, and Goebel, W: Role of E. coli hemolysin and bacterial adherence in infection: requirement for release of inflammatory mediates from granulocytes and mast cells. Infect. immun. 54, 886–899 (1986)

    Google Scholar 

  27. Gadeberg, OV and Orskov, J: In vitro cytotoxic effect of-hemolytic E. coli on human blood granulocytes. Immun. 45, 255–261 (1984)

    Google Scholar 

  28. Chakraborty, T, Huhle, B, Hof, H, Bergbauer, H and Goebel, W: Marker exchange mutagenesis of the aerolysindeterminant in Aeromonas hydrophila demonstrates the role of cereolysin in A. hydrophila-associated systemic infections. Infect. Immun. 55, 2274–2280 (1987)

    Google Scholar 

  29. Rocourt, J, Seeliger, HPR: Is haemolysis an in vitro marker of the pathogenic strains of the genus Listeria. Ann. Microbiol. (Institut Pasteur) 138, 277–279 (1987)

    Google Scholar 

  30. Kathariou, S, Rocourt, J, Hof, H and Goebel, W: Levels of L. monocytogenes hemolysin are not directly proportional to virulence in experimental infections of mice. Infect. Immun. 56, 534–536 (1988)

    Google Scholar 

  31. Kuhn, M, Kathariou, S and Goebel, W: Hemolysin supports survival but not entry of the intracellular bacterium Listeria monocytogenes. Infect. Immun. 56, 79–82 (1988)

    Google Scholar 

  32. Kuhn M and Goebel W: Identification of an extracellular protein of L. monocytogenes possibly involved in intracellular uptake by mammalian cells. Infect. Immun. (in press)

  33. Gaillard, JL, Berche, P, Mounier, J, Richard, S and Sansonetti, P: In vitro model of penetration and intracellular growth of L. monocytogenes in the human enterocyte-like cell line Caco-2. Infect. Immun. 55, 2822–2829 (1987)

    Google Scholar 

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Authors and Affiliations

  1. Institute for Genetics and Microbiology, University of Würzburg, Würzburg, W.-Germany

    Goebel W., T. Chakraborty & J. Kreft

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  1. Goebel W.
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  2. T. Chakraborty
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  3. J. Kreft
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Goebel, W., Chakraborty, T. & Kreft, J. Bacterial hemolysins as virulence factors. Antonie van Leeuwenhoek 54, 453–463 (1988). https://doi.org/10.1007/BF00461864

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