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Effects of phencyclidine, haloperidol, and naloxone on fixed-interval performance in rats

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Abstract

Phencyclidine (PCP), haloperidol, and naloxone were administered alone and in combination to rats responding under a fixed-interval schedule for water presentation. Lower doses of PCP (0.25–2.0 mg/kg) and naloxone (0.001–0.1 mg/kg) produced increases while higher doses produced dose-dependent decreases in response rate. Haloperidol (0.0625–0.5 mg/kg) produced a monotonic dose-dependent decrease in responding. When a dose of naloxone (8.0 mg/kg) that did not alter responding was administered prior to the PCP, the PCP dose-response curve was shifted to 6.5-fold lower doses of PCP. When a dose of haloperidol (0.0625 mg/kg) that did not alter responding was administered prior to the PCP, the PCP dose-response curve was shifted to 1.5-fold higher dose of PCP. These observations are discussed in relation to current views of the mechanism of PCP action.

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Authors and Affiliations

  1. Department of Psychology, Rutgers University, Busch Campus, 08903, New Brunswick, NJ, USA

    George C. Wagner, David B. Masters & Arthur Tomie

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  1. George C. Wagner
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  2. David B. Masters
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  3. Arthur Tomie
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Wagner, G.C., Masters, D.B. & Tomie, A. Effects of phencyclidine, haloperidol, and naloxone on fixed-interval performance in rats. Psychopharmacology 84, 32–38 (1984). https://doi.org/10.1007/BF00432020

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  • DOI: https://doi.org/10.1007/BF00432020

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