Summary
The frequency distribution of tissue mast cells and eosinophilic granulocytes in tumor-draining lymph nodes was evaluated. In total 483 axillary lymph nodes draining invasive ductal breast cancer and 162 paracolic lymph nodes draining infiltrating adenocarcinoma of the large bowel were analyzed. Significantly higher number of sinus mast cells were found in axillary lymph nodes as compared with the paracolic ones whereas eosinophilic granulocytes were more frequent in paracolic than in axillary lymph nodes. Concerning both cell systems no significant differences could be demonstrated when all lymph nodes from nodal-negative cases were compared with the lymph nodes from cases with regional lymph node metastases. Tumor-free axillary lymph nodes, however, showed a significantly higher mast cell content in the sinus and medulla than did lymph nodes bearing metastases. The number of eosinophilic granulocytes did not differ in either lymph node group.
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Bedwani R, Vana J, Rosner D, Schmitz RL, Murphy GP (1981) Management and survival of female patients with “minimal” breast cancer: as observed in the long-term and short-term surveys of the American College of Surgeons. Cancer 47:2769–2778
Bowers Jr HM, Mahapatro RC, Kennedy JW (1979) Numbers of mast cells in the axillary lymph nodes of breast cancer patients. Cancer 43:568–573
Fisher ER, Palekar A, Rockette H, Redmond C, Fisher B (1978) Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no. 4). V. Significance of axillary nodel micro-and macrometastases. Cancer 42:2032–2038
Henderson WR, Chi EY, Jong EC, Klebanoff SJ (1981) Mast cell-mediated tumor-cell cytotoxicity: Role of the peroxidase system. J Exp Med 153:520–533
Horny H-P, Horst H-A (1984) Quantitative immunhistologische Befunde an Lymphknoten im Abflußgebiet von nicht-metastasierten und metastasierten Mamma- und Coloncarcinomen. Verh Dtsch Ges Path 68:47–66
Huvos AG, Hutter RVP, Berg JW (1971) Significance of axillary macrometastases and micrometastases in mammary cancer. Ann Surg 173:44–46
Jong EC, Klebanoff SJ (1980) Eosinophil-mediated mammalian tumor cell cytotoxicity: role of the peroxidase system. J Immunol 124:1949–1956
Kay AB, McVie JG, Stuart AE, Krajewaki A, Turnbull LW (1975) Eosinophil chemotaxis of supernatants from cultured Hodgkin's lymph node cells. J Clin Path 28:502–505
Leder LD (1964) Über die selektive fermentcytochemische Darstellung von neutrophilen myeloischen Zellen und Gewebsmastzellen im Paraffinschnitt. Klin Wochenschr 42:553
Lennert K (1961) Lymphknoten. Diagnostik in Schnitt und Ausstrich. Bandteil A: Cytologie und Lymphadenitis. In: Lubarsch O, Henke F, Rössler R, Uehlinger E (Hrsg), Handbuch der speziellen pathologischen Anatomie und Histologie. 1, 3A. Springer, Berlin Göttingen Heidelberg
Lennert K, Illert E (1959) Die Häufigkeit der Gewebsmastzellen im Lymphknoten bei verschiedenen Erkrankungen. Frankf Zeitschr Pathol 70:121–131
Lowe D, Jorizzo J, Hutt MSR (1981) Tumour-associated esosinophilia: a review. J Clin Pathol 34:1343–1348
Mahapatro RC, Bowers Jr HM (1979) Distribution of mast cells in the axillary lymph nodes of breast cancer patients. Cancer 44:592–597
Noirot C, Leynadier F, Luce H, Abuaf N, Bernard PF, Dry J (1982) Hypereosinophilie au cours des cancer et des cirrhoses: Interet du compte absolu des eosinophiles. Sem Hop Paris 58:133–137
Pretlow TP, Keith EF, Cryar AK, Bartolucci AA, Pitts AM, Prerlow II TG, Kimball PM, Boohaker EA (1983) Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. Cancer Res 43:2997–3000
Sluungaard A, Ascensao J, Zanjani E, Jacob HS (1983) Pulmonary carcinoma with eosinophilia. New Engl J Med 309:778–781
Syrjänen KJ, Hjelt LH (1977) Paracortical activity of the regional lymph nodes as a prognositic determinant in gastric carcinoma. Scand J Gastroenterol 12:897–902
Syrjänen KJ, Hjelt LH (1978) Tumor-host relationships in colorectal carcinoma. Dis Colon Rectum 21:29–36
Thoresen S, Hartveit F (1982) Mast cells and the nodal sinus reaction in breast cancer. Histopathology 6:765–769
Wasserman SI, Goetzl EJ, Ellman L, Austen KF (1974) Tumor-associated eosinophilotactic factor. New Engl J Med 290:420–424
Yoon IL (1959) The eosinophil and gastrointestinal carcinoma. Am J Surg 97:195–200
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Supported by the Schleswig-Holsteinische Krebsgesellschaft e. V. and the Tumor-Zentrum Kiel e. V.
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Horny, H.P., Horst, H.A. Frequency distribution of tissue mast cells and eosinophilic granulocytes in tumor-draining axillary and paracolic lymph nodes. J Cancer Res Clin Oncol 112, 151–155 (1986). https://doi.org/10.1007/BF00404399
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DOI: https://doi.org/10.1007/BF00404399