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The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents

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Abstract

Among 15 chelating agents tested, sodium-2,3-dimercaptopropane-1-sulfonate (DMPS), 2,3-dimercaptopropanol (BAL), sodium-mercaptoethyliminodiacetate (MEIDA), and D-penicillamine (PA) exerted an influence on the excretion of Hg and its distribution in the organs. The excretion pattern, however, is different for these compounds, and, from the practical point of view, a favourable effect is exhibited only by DMPS which enhances the urinary excretion rate and lowers the Hg-concentration in all organs.

Zusammenfassung

Unter 15 untersuchten Chelatbildnern wurden die Ausscheidung und Organ-verteilung von Hg nur durch Natrium-2,3-Dimercaptopropan-1-sulfonat (DMPS), 2,3-Dimercaptopropanol (BAL), Natrium-Mercaptoäthyliminodiacetat (MEIDA) und D-Penicillamin (PA) beeinflußt. Das Ausscheidungsmuster ist jedoch bei diesen Substanzen unterschiedlich, und einen praktisch günstigen Effekt zeigt nur DMPS, das die renale Ausscheidungsrate erhöht und die Hg-Konzentration in allen Organen senkt.

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  1. Institut für Strahlenbiologie, Kernforschungszentrum Karlsruhe, Karlsruhe

    B. Gabard

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  1. B. Gabard
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Gabard, B. The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents. Arch Toxicol 35, 15–24 (1976). https://doi.org/10.1007/BF00333982

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