Abstract
We seek to understand the relative contribution of allelic variations of a particular gene to the determination of an individual's risk of atherosclerosis or hypertension. Work in progress is focusing on the identification and characterization of mutations in candidate genes that are known to be involved in determining the phenotypic expression of intermediate biochemical and physiological traits that are in the pathway of causation between genetic variation and variation in risk of disease. The statistical strategy described in this paper is designed to aid geneticists and molecular biologists in their search to find the DNA sequences responsible for the genetic component of variation in these traits. With this information we will have a more complete understanding of the nature of the organization of the genetic variation responsible for quantitative variation in risk of disease. It will then be possible to fully evaluate the utility of measured genetic information in predicting the risk of common diseases having a complex multifactorial etiology, such as atherosclerosis and hypertension.
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References
AquadroC.F.,DesseS.F.,BlandM.M.,LangleyC.H. andLaurie-AhlbergC.C. (1986): Molecular population genetics of the alcohol dehydrogenase gene region ofDrosophila melanogaster - Genetics114: 1165–1190.
Davignon J., Dufour R. and Cantin M. (1983): Atherosclerosis and Hypertension - In: Hypertension, Second Edition, Genest J. et al. (eds). McGraw-Hill - Chapter 53, pp: 810–852.
KaprioJ.,FerrellR.E.,KottkeB.A.,TurnerS.T. andSingC.F. (1991): Effect of polymorphisms in apolipoproteins E, A-IV and H on quantitative traits related to risk for cardiovascular disease -Arteriosclerosis -11: 1330–1348.
KimuraM. (1983): The Neutral Theory of Molecular Evolution. Cambridge University Press, New York.
NeterJ.,WassermanW. andKutnerM.H. (1985): Applied Linear Statistical Models, Edition 2 -Richard D. Irwin, Inc. Homewood, Ill.
RoychoudhuryA.K. andNeiM. (1988): Human Polymorphic Genes - World Distribution - Oxford University Press, New York.
SingC.F.,BoerwinkleE.,MollP.P. andTempletonA.R. (1988): Characterization of genes affecting quantitative traits in humans. In: Proceedings of the 2nd International Conference on Quantitative Genetics, B.S. Weir, E.J. Eisen M.M. Goodman and G. Namkoong (eds.). Sinauer - Sunderland - MA. pp: 250–269.
SingC.F. andMollP.P. (1990): Strategies for unravelling the genetic basis of coronary artery disease. In: From Phenotype to Gene in Common Disorders, K. Berg, N. Retterstol, S. Refsum (eds.). Munksgaard A/S International Publishers, Copenhagen, Denmark.
SoberE. (1983): Parsimony in Systematics: Philosophical Issues. Ann. Rev. Ecol. Syst.14:335–357.
TempletonA.R.,BoerwinkleE. andSingC.F. (1987): A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity inDrosophila - Genetics117:343–351.
TempletonA.R.,SingC.F.,KesslingA. andHumphriesS. (1988): A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. II. The analysis of natural populations. - Genetics120:1145–1154.
Templeton A.R., Crandall K.A. andSing C.F. (1992): A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA Sequence data. III. Cladogram estimation. Genetics - In press.
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Sing, C.F., Haviland, M.B., Zerba, K.E. et al. Application of cladistics to the analysis of genotype-phenotype relationships. Eur J Epidemiol 8 (Suppl 1), 3–9 (1992). https://doi.org/10.1007/BF00145343
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DOI: https://doi.org/10.1007/BF00145343