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Structures and Molecular Composition of Schmidt–Lanterman Incisures

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Myelin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1190))

Abstract

Schmidt–Lanterman incisure (SLI) is a circular-truncated cone shape in the myelin internode that is a specific feature of myelinated nerve fibers formed in Schwann cells in the peripheral nervous system (PNS). The SLI circular-truncated cones elongate like spring at the narrow sites of beaded appearance nerve fibers under the stretched condition. In this chapter, we demonstrate various molecular complexes in SLI, and especially focus on membrane skeleton, protein 4.1G–membrane protein palmitoylated 6 (MPP6)–cell adhesion molecule 4 (CADM4). 4.1G was essential for the molecular targeting of MPP6 and CADM4 in SLI. Motor activity and myelin ultrastructures were abnormal in 4.1G-deficient mice, indicating the 4.1G function as a signal for proper formation of myelin in PNS. Thus, SLI probably has potential roles in the regulation of adhesion and signal transduction as well as in structural stability in Schwann cell myelin formation.

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Acknowledgment

This work was partially supported by a grant from the Japanese Society for the Promotion of Science (KAKEN number 16K08463) to N. Terada.

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Authors and Affiliations

  1. Health Science Division, Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto City, Nagano, Japan

    Nobuo Terada, Yurika Saitoh & Akio Kamijo

  2. Center for Medical Education, Teikyo University of Science, Adachi-ku, Tokyo, Japan

    Yurika Saitoh

  3. Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan

    Junji Yamauchi

  4. Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Aichi, Japan

    Nobuhiko Ohno

  5. Department of Anatomy, Division of Histology and Cell Biology, Jichi Medical University, School of Medicine, Shimotsuke, Japan

    Nobuhiko Ohno

  6. Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan

    Takeharu Sakamoto

Authors
  1. Nobuo Terada
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  2. Yurika Saitoh
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  3. Akio Kamijo
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  4. Junji Yamauchi
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  5. Nobuhiko Ohno
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  6. Takeharu Sakamoto
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Corresponding author

Correspondence to Nobuo Terada .

Editor information

Editors and Affiliations

  1. Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Kazunori Sango

  2. Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan

    Junji Yamauchi

  3. Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center, Tokorozawa, Saitama, Japan

    Toru Ogata

  4. Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA

    Keiichiro Susuki

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Terada, N., Saitoh, Y., Kamijo, A., Yamauchi, J., Ohno, N., Sakamoto, T. (2019). Structures and Molecular Composition of Schmidt–Lanterman Incisures. In: Sango, K., Yamauchi, J., Ogata, T., Susuki, K. (eds) Myelin. Advances in Experimental Medicine and Biology, vol 1190. Springer, Singapore. https://doi.org/10.1007/978-981-32-9636-7_12

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