Abstract
The skin provides the primary protection for the body against external injuries and is essential in the maintenance of general homeostasis. During ageing, resident cells become senescent and the extracellular matrix, mainly in the dermis, is progressively damaged affecting the normal organization of the skin and its capacity for repair. In parallel, extrinsic factors such as ultraviolet irradiation, pollution, and intrinsic factors such as diabetes or vascular disease can further accelerate this phenomenon. Indeed, numerous mechanisms are involved in age-induced degradation of the skin and these also relate to non-healing or chronic wounds in the elderly. In particular, the generation of reactive oxygen species seems to play a major role in age-related skin modifications. Certainly, targeting both the hormonal status of the skin or its surface nutrition can slow down age-induced degradation of the skin and improve healing of skin damage in the elderly. Skin care regimens that prevent radiation and pollution damage, and reinforce the skin surface and its microbiota are among the different approaches able to minimize the effects of ageing on the skin.
Keywords
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Learn about institutional subscriptionsAbbreviations
- ADSC:
-
adipose tissue-derived stem cell
- AGEs:
-
advanced glycation end-products
- AMPK:
-
adenosine monophosphate-activated protein kinase
- AP-1:
-
activator protein-1
- CR:
-
caloric restriction
- CTGF:
-
connective tissue growth factor
- DEJ:
-
dermal-epidermal junction
- ECM:
-
extracellular matrix
- HSD:
-
hydroxysteroid dehydrogenase
- IL:
-
interleukin
- IR:
-
infrared radiation
- MB:
-
methylene blue
- MMP:
-
matrix metalloproteinase
- MSC:
-
mesenchymal stem cell
- NT:
-
neurotrophin
- PDGF:
-
platelet-derived growth factor
- ROS:
-
reactive oxygen species
- SOD:
-
superoxide dismutase
- TGF-β1:
-
transforming growth factor-β1
- TIMPs:
-
tissue inhibitors of metalloproteinases
- TNF-α:
-
tumour necrosis factor-α
- UV:
-
ultraviolet
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Bonté, F., Girard, D., Archambault, JC., Desmoulière, A. (2019). Skin Changes During Ageing. In: Harris, J., Korolchuk, V. (eds) Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Subcellular Biochemistry, vol 91. Springer, Singapore. https://doi.org/10.1007/978-981-13-3681-2_10
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