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Myopia Genes in Asians

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Advances in Vision Research, Volume II

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Myopia is the most common ocular disorder causing visual impairment worldwide. It is a public health issue in many parts of the world. Compared with Caucasian or other ethnicities, its prevalence in Asians, especially Japanese, Koreans, and Chinese, is much higher. Environmental and genetic factors play important roles in myopia development. Myopia is a multifactorial disease. Time spent outdoors, amount of near work, and educational level influence myopia onset and progression. Recent advances in modern technology and molecular biology including linkage analyses, candidate gene analysis, genome-wide association studies (GWAS), whole-exome sequencing (WES), and next-generation sequencing (NGS) have led to mapping and identifying many myopia-associated gene loci and variants. Understanding the genetic basis may help in myopia prediction and prevention. This review is to summarize recent major findings in myopia genetics with a focus in Asian populations.

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Compliance with Ethical Requirements

Shumin Tang, Yu Meng Wang, Aziz K. W. Kam, Tommy C. Y. Chan, Calvin C. P. Pang, Jason C. S. Yam, and Guy L. J. Chen declare that they have no conflict of interest. No human or animal studies were performed by the authors for this article.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China

    Shumin Tang, Yu Meng Wang, Tommy C. Y. Chan, Calvin C. P. Pang, Jason C. S. Yam & Guy L. J. Chen

  2. Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China

    Aziz K. W. Kam

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  1. Shumin Tang
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  3. Aziz K. W. Kam
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Correspondence to Guy L. J. Chen .

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Editors and Affiliations

  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA

    Gyan Prakash

  2. National Institute of Sensory Organs Tokyo Medical Center, National Hospital Organization, Tokyo, Japan

    Takeshi Iwata

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Tang, S. et al. (2019). Myopia Genes in Asians. In: Prakash, G., Iwata, T. (eds) Advances in Vision Research, Volume II. Essentials in Ophthalmology. Springer, Singapore. https://doi.org/10.1007/978-981-13-0884-0_34

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  • DOI: https://doi.org/10.1007/978-981-13-0884-0_34

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