Abstract
Upregulation of DJ-1 mRNA is commonly observed in various human cancers such as ductal carcinoma of the breast, non-small cell carcinoma of the lung, pancreatic duct adenocarcinoma, urinary transitional cell carcinoma, and gynecologic carcinoma. At the protein level, intensity and intracellular localization of DJ-1 expression is varied, and the DJ-1 protein regulates cancer progression, clinical aggressiveness, differentiation, cancer cell morphology, and drug sensitivity. Thus, DJ-1 plays a critical role in cancer. Although DJ-1 has an important role within cancer cells, cancer cells secrete DJ-1 outside the cells. DJ-1 may serve as a tumor marker that can be detected from an early stage in the blood, secretory fluids, ascites, or pleural effusion.
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Kawate, T., Tsuchiya, B., Iwaya, K. (2017). Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance. In: Ariga, H., Iguchi-Ariga, S. (eds) DJ-1/PARK7 Protein. Advances in Experimental Medicine and Biology, vol 1037. Springer, Singapore. https://doi.org/10.1007/978-981-10-6583-5_4
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DOI: https://doi.org/10.1007/978-981-10-6583-5_4
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