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Human Cytochrome P450 and Personalized Medicine

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Advance in Structural Bioinformatics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 827))

Abstract

Personalized medicine has become a hot topic ascribed to the development of Human Genome Project. And currently, bioinformatics methodology plays an essential role in personal drug design. Here in this review we mainly focused on the basic introduction of the SNPs of human drug metabolic enzymes and their relationships with personalized medicine. Some common bioinformatics analysis methods and latest progresses and applications in personal drug design have also been discussed. Thus bioinformatics studies on SNPs of human CYP450 genes will contribute to indicate the most possible genes that are associated with human diseases and relevant therapeutic targets, identify and predict the drug efficacy and adverse drug response, investigate individual gene specific properties and then provide personalized and optimal clinic therapies.

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Authors and Affiliations

  1. State Key Laboratory of Microbial Metabolism, College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

    Qi Chen & Dongqing Wei

Authors
  1. Qi Chen
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  2. Dongqing Wei
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Correspondence to Dongqing Wei .

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Editors and Affiliations

  1. Shanghai JiaoTong University, Shanghai, China

    Dongqing Wei

  2. Shanghai Jiao Tong University, Shanghai, China

    Qin Xu

  3. Shanghai Jiao Tong University, Shanghai, China

    Tangzhen Zhao

  4. Shanghai Jiao Tong University, Shanghai, China

    Hao Dai

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© 2015 Shanghai Jiaotong University Press, Shanghai and Springer Science+Business Media Dordrecht

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Chen, Q., Wei, D. (2015). Human Cytochrome P450 and Personalized Medicine. In: Wei, D., Xu, Q., Zhao, T., Dai, H. (eds) Advance in Structural Bioinformatics. Advances in Experimental Medicine and Biology, vol 827. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9245-5_20

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