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Transient Receptor Potential Channels pp 929–945Cite as

Oncogenic TRP Channels

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

Ion channels and notably TRP channels play a crucial role in a variety of physiological functions and in addition these channels have been also shown associated with several diseases including cancer. The process of cancer initiation and progression involves the altered expression of one or more of TRP proteins, depending on the nature of the cancer. The most clearly described role in pathogenesis has been evidenced for TRPM8, TRPV6 and TRPM1 channels. The increased expression of some other channels, such as TRPV1, TRPC1, TRPC6, TRPM4, and TRPM5 has also been demonstrated in some cancers. Further investigations are required to precise the role of TRP channels in cancer development and/or progression and to specifically develop further knowledge of TRP proteins as discriminative markers and prospective targets for pharmaceutical intervention in treating cancer.

An erratum to this chapter can be found athttp://dx.doi.org/10.1007/978-94-007-0265-3_53

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Authors and Affiliations

  1. Department of Molecular Medicine, sapienza University of Rome, 10161, Rome, Italy

    V’yacheslav Lehen’kyi

  2. Inserm, U-800, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d’Ascq, F-59655, France

    Natalia Prevarskaya

  3. Université des Sciences et Technologies de Lille (USTL), Villeneuve d’Ascq, F-59655, France

    Natalia Prevarskaya

  4. Laboratoire de Physiologie Cellulaire, INSERM U1003, USTL, Villeneuve d’Ascq Cedex, F-59655, France

    Natalia Prevarskaya

Authors
  1. V’yacheslav Lehen’kyi
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  2. Natalia Prevarskaya
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Correspondence to Natalia Prevarskaya .

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Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Lehen’kyi, V., Prevarskaya, N. (2011). Oncogenic TRP Channels. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_48

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