Abstract
There is an extensive body of literature documenting the association of proteases with cancer. Indeed, a search of PubMed for the phrase “proteases in cancer” brings up a list of ~73,000 papers, including >7,200 reviews. Nonetheless, the protease community still has not identified and validated all of the proteases and proteolytic pathways that play causal roles in neoplastic progression, nor determined which proteases would be appropriate therapeutic targets in pre-malignant lesions as compared to end-stage cancers or in any one type of cancer. Furthermore, more than one catalytic type of protease has been implicated in the progression of human tumors, as have interactions among proteases of more than one catalytic type. How vast a repertoire of proteases has been implicated in cancer is evident from a recent comprehensive tome on the many proteases that comprise the cancer degradome (Edwards et al. 2008b).
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Sloane, B.F., List, K., Fingleton, B., Matrisian, L. (2013). Proteases in Cancer: Significance for Invasion and Metastasis. In: Brix, K., Stöcker, W. (eds) Proteases: Structure and Function. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0885-7_15
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