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The Relationship Between Opioids and Immune Signalling in the Spinal Cord

  • Chapter
Pain Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 227))

Abstract

Opioids are considered the gold standard for the treatment of moderate to severe pain. However, heterogeneity in analgesic efficacy, poor potency and side effects are associated with opioid use, resulting in dose limitations and suboptimal pain management. Traditionally thought to exhibit their analgesic actions via the activation of the neuronal G-protein-coupled opioid receptors, it is now widely accepted that neuronal activity of opioids cannot fully explain the initiation and maintenance of opioid tolerance, hyperalgesia and allodynia. In this review we will highlight the evidence supporting the role of non-neuronal mechanisms in opioid signalling, paying particular attention to the relationship of opioids and immune signalling.

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Authors and Affiliations

  1. Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia

    Jacob Thomas, Jacinta Johnson & Lauren Nicotra

  2. Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, Australia

    Sanam Mustafa & Mark Hutchinson

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    Hans-Georg Schaible

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Thomas, J., Mustafa, S., Johnson, J., Nicotra, L., Hutchinson, M. (2015). The Relationship Between Opioids and Immune Signalling in the Spinal Cord. In: Schaible, HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46450-2_11

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