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Human Tumour Xenograft Models for Use with an In Vitro-Based, Disease-Oriented Antitumour Drug Screening Program

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Book cover Human Tumour Xenografts in Anticancer Drug Development

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Both short-term and long-term xenograft models may be useful in conjunction with an in vitro based disease-oriented drug screening program. Shortterm models may be most valuable in making initial assessments of the potential in vitro drug screening leads for in vivo use. We have previously shown that a substantial number of such leads may be subject to metabolic inactivation (1) and that this may be associated with a lack of therapeutic activity and a relative lack of toxicity in vivo. Certainly, rapid excretion or other pharmacologic factors may also render compounds inactive in vivo. Short-term as says may be very useful for identifying such compounds and thus setting priorities for further testing of in vitro drug leads in more rigorous longer-term models. Rational application of these longer-term models with particular attention to modeling of in situ vascular barriers, tumor microenvironment, and the natural history of the target diseases may facilitate identification and development of new drugs with significant clinical activity against the common adult solid tumors.

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Author information

Authors and Affiliations

  1. Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD, 20892, USA

    R. H. Shoemaker, T. L. McLemore, B. J. Abbott, J. G. Mayo & M. R. Boyd

  2. Program Resources, Inc., National Cancer Institute - Frederick Cancer Research Facility, Frederick, MD, 21701, USA

    D. L. Fine

  3. Pittsburgh Cancer Institute, 230 Lothrop Street, Pittsburgh, PA, 15213, USA

    E. Gorelik

  4. Institute for Cancer Research, Montebello, 0310, Oslo 3, Norway

    Ø. Fodstad

Authors
  1. R. H. Shoemaker
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  2. T. L. McLemore
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  3. B. J. Abbott
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  4. D. L. Fine
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  5. E. Gorelik
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  6. J. G. Mayo
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  7. Ø. Fodstad
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  8. M. R. Boyd
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Editor information

Editors and Affiliations

  1. EORTC New Drug Development Office, Free University Hospital, De Boelelaan 1117, NL-1081 HV, Amsterdam, The Netherlands

    Benjamin Winograd

  2. Central Office, British Postgraduate Medical Federation, 33, Millman Street, London, WC1N 3EG, UK

    Michael Peckham

  3. Department of Oncology, Free University Hospital, De Boelelaan 1117, NL-1081 HV, Amsterdam, The Netherlands

    Herbert Michael Pinedo

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© 1988 Springer-Verlag Berlin Heidelberg

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Shoemaker, R.H. et al. (1988). Human Tumour Xenograft Models for Use with an In Vitro-Based, Disease-Oriented Antitumour Drug Screening Program. In: Winograd, B., Peckham, M., Pinedo, H.M. (eds) Human Tumour Xenografts in Anticancer Drug Development. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73252-2_21

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  • DOI: https://doi.org/10.1007/978-3-642-73252-2_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73254-6

  • Online ISBN: 978-3-642-73252-2

  • eBook Packages: Springer Book Archive

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