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T Cells and Effector Mechanisms in Atopic Dermatitis

  • Chapter
New Trends in Allergy V

Abstract

T cells constitute a large population of cellular infiltrate in atopic dermatitis (AD) and a dysregulated, cytokine mediated immune response appears to be an important pathogenetic factor.The great majority of T cells homing to skin express CD45RO+ memory/effector phenotype and the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen (CLA). Aeroallergens, food antigens, autoantigens and bacterial superantigens activate T cells in AD. Continuous Stimulation of T cells in lymphatic organs and skin plays an important role in AD with induction of hyper IgE and eosinophilia. Activated T cells induce keratinocyte apoptosis as a key pathogenetic event in the formation of eczema. To mediate these effector functions after skin homing, activated T cells show continuous survival in the skin. Activât ion-induced cell death of T cells (AICD) is prevented by cytokines and extracellular matrix components in the eczematous skin.

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References

  1. CA Akdis, M Akdis, A Trautmann, K Blaser. Immune regulation in atopic dermatitis. Current Opin Immunol 12:641–646,2000.

    Article  CAS  Google Scholar 

  2. LF Santamaria Babi, LJ Picker, MT Perez Soler, K Drzimalla, P Flohr, K Blaser, C Hauser. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 181:1935–1940,1995.

    Article  PubMed  CAS  Google Scholar 

  3. M Akdis, CA Akdis, L Weigl, R Disch, K Blaser. Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern. IgG4 counter-regulation by CLA-memory T cells. J Immunol 159:4611–4619,1997.

    PubMed  CAS  Google Scholar 

  4. Y Shimada, S Sato, M Hasegawa, TF Tedder, K Takehara. Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble Lselectin levels indicate disease severity. J Allergy Clin Immunol 104:163–168,1999.

    Article  PubMed  CAS  Google Scholar 

  5. VA Varney, QA Hamid, M Gaga, S Ying, M Jacobson, AJ Frew, AB Kay, SR Durham. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 92:644–651,1993.

    Article  PubMed  CAS  Google Scholar 

  6. T Werfel, A Morita, M Grewe, H Renz, U Wahn, J Krutmann, A Kapp. Allergen-specificity of skin-infiltratin g T-cells is not restricted to a type 2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 107:871–876,1996.

    Article  PubMed  CAS  Google Scholar 

  7. KJ Abernathy-Carver, HA Sampson, LJ Picker, DYM Leung. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 95:913–918,1995.

    Article  PubMed  CAS  Google Scholar 

  8. M Akdis, H-U Simon, L Weigl, O Kreyden, K Blaser, CA Akdis. Skin homing (Cutaneous Lymphocyte-Associated Antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 163:466–475,1999.

    PubMed  CAS  Google Scholar 

  9. CA Akdis, M Akdis, D Simon, B Dibbert, M Weber, S Gratzl, O Kreyden, R Disch, B Wiithrich, K Blaser, H-U Simon. T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J Invest Dermatol 113:628–634,1999.

    Article  PubMed  CAS  Google Scholar 

  10. MC Chou, SC Lee, YS Lin, HY Lei. Vb 8+ CD4’ CD8’ subpopulation induced by staphylococcal enterotoxin B. Immunol Let 55:85–91,1997.

    Article  CAS  Google Scholar 

  11. JE Leyden, RR Marpies, AM Kligman. Staphylococcus aureus in the lesions of atopic dermati tis. Br J Dermatol 90:525–530,1974.

    Article  PubMed  CAS  Google Scholar 

  12. P Strange, L Skov, S Lisby, PL Nielsen, O Baadsgaard. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 132:27–33,1996.

    Article  PubMed  CAS  Google Scholar 

  13. U Herz, N Schnoy, S Borelli, L Weigl, U Käsbohrer, A Daser, U Wahn, R Köttgen, H Renz. A hu-SCID mouse model for allergie immune responses: Bacterial superantigen enhances skin inflammation and supresses IgE production. J Invest Dermatol 110:224–231,1998.

    Article  PubMed  CAS  Google Scholar 

  14. DYM Leung, R Harbeck, P Bina, JM Hanifin, RE Reiser, HA Sampson. Presence of IgE antibodies to staphylococcal exotoxins in the skin of patients with atopic dermatitis: evidence for anew group of allergens. J Clin Invest 92:1374–1380,1993.

    Article  PubMed  CAS  Google Scholar 

  15. M Akdis, S Klunker, M Schliz, K Blaser, CA Akdis. Expression of cutaneous lymphocyte-associated antigen on human CD4+ and CD8+ TI12 cells. Eur J Immunol 30:3533–3541,2000.

    Article  PubMed  CAS  Google Scholar 

  16. DYM Leung, RS Cotran, JS Pober. Expression of an endothelial leukocyte adhesion molecule (ELAM-i) in elicited late phase allergie skin reactions. J Clin Invest 87:1805–1810,1991.

    Article  PubMed  CAS  Google Scholar 

  17. DYM Leung. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105:860–876,2000.

    Article  PubMed  CAS  Google Scholar 

  18. Q Hamid, M Boguniewicz, DYM Leung. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870–876,1994.

    Article  PubMed  CAS  Google Scholar 

  19. M Grewe, CAFM Bruijnzeel-Koomen, E Schöpf, T Thepen, AG Langeveld-Wildschut, T Ruzicka, J Krutmann. A role for Thi and TI12 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 19:359–361,1998.

    Article  PubMed  CAS  Google Scholar 

  20. T Thepen, EG Langeveld-Wildschut, LC Biliari, DF van Wichen, FC Van Reijsen, GC Mudde, CAFM Bruijnzeel-Koomen. Biphasic response against aero allergen in atopic dermatitis showing a switch from an initial TI12 response to a Thi response in situ: An immunochemical study. J Allergy Clin Immunol 97:828–837,1996.

    Article  PubMed  CAS  Google Scholar 

  21. M Grewe, W Czech, A Morita, T Werfel, M Klammer, A Kapp, T Ruzicka, E Schöpf, J Krutmann. Human eosinophils produce biologically active IL-12: implications for control of T cell responses. J Immunol 161:415–420,1998.

    PubMed  CAS  Google Scholar 

  22. K Kang, M Kubin, KD Cooper, SR Lessin, G Trinchieri, AH Rook. IL-12 synthesis by human Langerhans cells. J Immunol 156:1402–1407,1996.

    PubMed  CAS  Google Scholar 

  23. G Müller, J Saloga, T Germann, I Bellinghausen, M Mohamadzadeh, J Knop, AH Enk. Identification and induction of human keratinocyte-derived IL-12. J Clin Invest 94:1799–1805,1994.

    Article  PubMed  Google Scholar 

  24. S Stoll, H Jonuleit, E Schmitt, G Müller, H Yamauchi, M Kurimoto, J Knop, AH Enk. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Thi development. Eur J Immunol 28:3231–3239,1998.

    Article  PubMed  CAS  Google Scholar 

  25. JM Hanifin, G Rajka. Diagnostic features of atopic dermatitis. Acta Derm Venerol 92:44–47,1980.

    Google Scholar 

  26. B Wüthrich. Serum IgE in atopic dermatitis. Clin Allergy 8:241–248,1978.

    Article  PubMed  Google Scholar 

  27. M Akdis, A Trautmann, S Klunker, H-U Simon, D Simon, R Disch, K Blaser, CA Akdis. Regulation of allergie inflammation by T cells and cytokines in atopic dermatitis. Int Arch Allergy Immunol 124:296–298,2001.

    Article  CAS  Google Scholar 

  28. H-U Simon, K Blaser. Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia. Immunol Today 16:53–55,1995.

    Article  PubMed  CAS  Google Scholar 

  29. DR Green, DW Scott. Activation-induced apoptosis in lymphocytes. Curr Opin Immunol 6:476–487,1994.

    Article  PubMed  CAS  Google Scholar 

  30. M Akdis, A Trautmann, K Blaser, CA Akdis. Lifespan of skin homing T cells in atopic dermatitis: survival in skin, activation induced apoptosis in peripheral blood. J Allergy Clin Immunol 105:167,2000.

    Article  Google Scholar 

  31. EA Clöark, SJ Brugge. Integrins and signal transduction pathways: The road taken. Science 268:233–238,1995.

    Article  Google Scholar 

  32. JG Giri, S Kumaki, M Ahdieh, DJ Friend, A Loomis, K Shanebeck, R Dubose, D Cosman, LS Park, DM Anderson. Identification and cloning of a novel IL-15 bindingproteinthatis structurally related to the a chain of the IL-2 receptor. EMBO J 14:3654–3663,1995.

    PubMed  CAS  Google Scholar 

  33. WC Li, A Ima, Y Li, XX Zheng, TR Malek, TB Strom. Blocking the common g-chain of cytokine receptors induces T cell apoptosis and long term islet allograft survival. J Immunol 164:1193–1199,2000.

    PubMed  CAS  Google Scholar 

  34. A Trautmann, M Akdis, D Kleeman, F Altznauer, H-U Simon, T Graeve, M Noll, K Blaser, CA Akdis. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 106:25–35,2000.

    Article  PubMed  CAS  Google Scholar 

  35. A Trautmann, M Akdis, K Blaser, CA Akdis. Role of dysregulated apoptosis in atopic dermatitis. Apoptosis 5:425–429,2001.

    Article  Google Scholar 

  36. C Traidl, S Sebastiani, C Albanesi, HF Merk, P Puddu, G Girolomoni, A Cavani. Disparate cytotoxic activity of ni ekel-specific CD8+ and CD4’1’ T cell subsets against keratinocytes. J Immunol 165:3058–3064,2000.

    PubMed  CAS  Google Scholar 

  37. B Schnyder, K Frutig, D Mauri-Hellweg, A Limat, N Yawalkar, WJ Pichler. T-cell mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reactions. Clin Exp Allergy 28:1412–1417,1998.

    Article  PubMed  CAS  Google Scholar 

  38. JM Spergel, E Mizoguchi, H Oettgen, AK Bhan, RS Geha. Roles of Thi andTli2 cytokines in a murine model of allergie dermatitis. J Clin Invest 103:1103–1111,1999.

    Article  PubMed  CAS  Google Scholar 

  39. JM Carroll, T Crompton, JP Seery, FM Watt. Transgenic mice expressing IFN-g in the epidermis have eczema, hair hypopigmentation and hair loss. J Invest Dermatol 108:412–422,1997.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. Akdis
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  2. A. Trautmann
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  3. S. Klunker
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  4. K. Blaser
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  5. C. A. Akdis
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein Klinikum Rechts der Isar, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Johannes Ring (Prof. Dr. Dr.) (Prof. Dr. Dr.)

  2. ZAUM—Zentrum für Allergie und Umwelt, Klin. Kooperationsgruppe Umweltdermatologie und Allergologie GSF, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Heidrun Behrendt (Prof. Dr.) (Prof. Dr.)

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© 2002 Springer-Verlag Berlin Heidelberg

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Akdis, M., Trautmann, A., Klunker, S., Blaser, K., Akdis, C.A. (2002). T Cells and Effector Mechanisms in Atopic Dermatitis. In: Ring, J., Behrendt, H. (eds) New Trends in Allergy V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55994-5_16

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  • DOI: https://doi.org/10.1007/978-3-642-55994-5_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62768-2

  • Online ISBN: 978-3-642-55994-5

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