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Cycloheximide and Other Glutarimide Antibiotics

  • Chapter
Mechanism of Action

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 1))

Abstract

A number of biologically active glutarimide derivatives have been isolated from various streptomycetes. The derivatives for which chemical structures have been determined include cycloheximide, naramycin B, isocycloheximide, streptimidone, acetoxycycloheximide, inactone and the streptovitacins. All have in common the β (2-hydroxyethyl) glutarimide moiety attached to a cyclic or acyclic ketone. Although the antibiotics are noted particularly for their antifungal properties, they are toxic to a broad spectrum of organisms. Yet, a highly interesting characteristic of these antibiotics is the marked difference in their activity toward closely related organisms.

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  1. Hugh D. Sisler
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  2. Malcolm R. Siegel
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Editors and Affiliations

  1. University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) & Paul D. Shaw (Associate Professor of Biochemistry) (Professor of Plant Pathology) &  (Associate Professor of Biochemistry)

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Sisler, H.D., Siegel, M.R. (1967). Cycloheximide and Other Glutarimide Antibiotics. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_21

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