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Neuropeptide Y: History and Overview

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Neuropeptide Y and Related Peptides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 162))

Abstract

Neuropeptide Y (NPY) is a 36-amino acid peptide with structural similarities to peptide YY (PYY) and pancreatic polypeptide (PP). NPY, one of the most abundant neuropeptides known, is widely distributed throughout the central and peripheral nervous systems, while PYY and PP are predominantly distributed in the endocrine cells of the intestine and pancreas, respectively. Five NPY receptor subtypes denoted as Y1, Y2, Y4, Y5, and y6 mediate the actions of NPY. NPY is involved in the regulation of diverse functions including food intake, blood pressure, circadian rhythms, stress, pain, hormone secretion, reproduction, and alcohol consumption. NPY has also been implicated in the pathophysiology of a number of diseases such as feeding disorders, seizures, hypertension, pain disorders, depression, and anxiety. This review will describe a brief history and an overview of the studies on NPY concerning the isolation, tissue distribution, receptor subtypes, receptor agonists and antagonists, physiological functions, and pharmacological activities.

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References

  • Adrian TE, Allen JM, Bloom SR et al. (1983) Neuropeptide Y distribution in human brain. Nature 306:584–586

    PubMed  CAS  Google Scholar 

  • Aicher SA, Springston M, Berger SB et al. (1991) Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain. Neurosci Lett 130:32–36

    PubMed  CAS  Google Scholar 

  • Albers HE, Ferris CF (1984) Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci Lett 50:163–168

    PubMed  CAS  Google Scholar 

  • Allen JM, Adrian TE, Tatemoto K et al. (1982) Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens. Neuropeptides 3:71–77

    PubMed  CAS  Google Scholar 

  • Allen JM, Rodrigo J, Yeats JC et al. (1984) Vascular distribution of neuropeptide Y (NPY) and effect on blood pressure. Clin Exp Hypertens A 6:1879–1882

    PubMed  CAS  Google Scholar 

  • Allen YS, Adrian TE, Allen JM et al. (1983) Neuropeptide Y distribution in the rat brain. Science 221:877–879

    PubMed  CAS  Google Scholar 

  • Balasubramaniam AA (1997) Neuropeptide Y family of hormones: receptor subtypes and antagonists. Peptides 18:445–457

    PubMed  CAS  Google Scholar 

  • Baraban SC, Hollopeter G, Erickson JC et al. (1997) Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci 17:8927–8936

    PubMed  CAS  Google Scholar 

  • Bard JA, Walker MW, Branchek TA, Weinshank RL (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J Biol Chem 270:26762–26765

    PubMed  CAS  Google Scholar 

  • Batterham RL, Cowley MA, Small CJ et al. (2002) Gut hormone PYY(3–36) physiologically inhibits food intake. Nature 418:650–654

    PubMed  CAS  Google Scholar 

  • Beck A, Jung G, Gaida W et al. (1989) Highly potent and small neuropeptide Y agonist obtained by linking NPY 1–4 via spacer to alpha-helical NPY 25–36. FEBS Lett 244:119–122

    PubMed  CAS  Google Scholar 

  • Boublik J, Scott N, Taulane J et al. (1989) Neuropeptide Y and neuropeptide Y18–36. Structural and biological characterization. Int J Pept Protein Res 33:11–15

    PubMed  CAS  Google Scholar 

  • Burkhoff A, Linemeyer DL, Salon JA (1998) Distribution of a novel hypothalamic neuropeptide Y receptor gene and it’s absence in rat. Brain Res Mol Brain Res 53:311–316

    PubMed  CAS  Google Scholar 

  • Caberlotto L, Fuxe K, Overstreet DH et al. (1998) Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Brain Res Mol Brain Res 59:58–65

    PubMed  CAS  Google Scholar 

  • Caberlotto L, Fuxe K, Hurd YL (2000) Characterization of NPY mRNA-expressing cells in the human brain: co-localization with Y2 but not Y1 mRNA in the cerebral cortex, hippocampus, amygdala, and striatum. J Chem Neuroanat 20:327–337

    PubMed  CAS  Google Scholar 

  • Chen X, Westfall TC (1993) Depressor effect of intrathecal neuropeptide Y (NPY) is mediated by Y2 subtype of NPY receptors. J Cardiovasc Pharmacol 21:720–724

    PubMed  CAS  Google Scholar 

  • Chronwall BN, DiMaggio, DA, Massari VJ et al. (1985) The anatomy of neuropeptide Y-containing neurons in rat brain. Neuroscience 15:1159–1181

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra PS, Crowley WR, Kalra SP (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115:427–429

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra PS, Kalra SP (1985) Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. Endocrinology 117:2435–2442

    PubMed  CAS  Google Scholar 

  • Colmers WF, Lukowiak K, Pittman Q (1988) Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition. J Neurosci 8:3827–337

    PubMed  CAS  Google Scholar 

  • Colmers WF, Klapstein GJ, Fournier A et al. (1991) Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor. Br J Pharmacol 102:41–44

    PubMed  CAS  Google Scholar 

  • Corder R, Emson PC, Lowry PJ (1984) Purification and characterization of human neuropeptide Y from adrenal-medullary phaeochromocytoma tissue. Biochem J 219:699–706

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Emson P, McCulloch J et al. (1983) Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat. Neurosci Lett 43:79–84

    PubMed  CAS  Google Scholar 

  • Erickson JC, Clegg KE, Palmiter RD (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415–421

    PubMed  CAS  Google Scholar 

  • Evequoz D, Waeber B, Aubert JF et al. (1988) Neuropeptide Y prevents the blood pressure fall induced by endotoxin in conscious rats with adrenal medullectomy. Circ Res 62:25–30

    PubMed  CAS  Google Scholar 

  • Everitt BJ, Hokfelt T (1989) The existence of neuropeptide Y with other peptides and amines in the central nervous system. In: Mutt V et al. (eds) Neuropeptide Y. Raven Press, New York, pp 61–71

    Google Scholar 

  • Ewald DA, Sternweis PC, Miller RJ (1988) Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons. Proc Natl Acad Sci USA 85:3633–3637

    PubMed  CAS  Google Scholar 

  • Flood JF, Hernandez EN, Morley JE (1987) Modulation of memory processing by neuropeptide Y. Brain Res 421:280–290

    PubMed  CAS  Google Scholar 

  • Fredholm BB, Jansen I, Edvinsson L (1985) Neuropeptide Y is a potent inhibitor of cyclic AMP accumulation in feline cerebral blood vessels. Acta Physiol Scand 124:467–469

    PubMed  CAS  Google Scholar 

  • Fuhlendorff I, Gether U, Aakerlund L et al. (1990) [Leu31, Pro34] neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci USA 87:182–186

    PubMed  CAS  Google Scholar 

  • Fukuhara C, Brewer JM, Dirden JC et al. (2001) Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleus. Neurosci Lett 314:119–122

    PubMed  CAS  Google Scholar 

  • Furtinger S, Pirker S, Czech T et al. (2001) Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy. J Neurosci 21:5804–5812

    PubMed  CAS  Google Scholar 

  • Fuxe K, Agnati LF, Harfstrand A et al. (1983) Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat. Acta Physiol Scand 118:189–192

    PubMed  CAS  Google Scholar 

  • Gehlert DR, Chronwall BM, Schafer MP, O’Donohue TL (1987) Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization. Synapse 1:25–31

    PubMed  CAS  Google Scholar 

  • Gehlert DR, Beavers LS, Johnson D et al. (1996) Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol 49:224–228

    PubMed  CAS  Google Scholar 

  • Gerald C, Walker MW, Vaysse PJ et al. (1995) Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J Biol Chem 270:26758–26761

    PubMed  CAS  Google Scholar 

  • Gerald C, Walker MW, Criscione L et al. (1996) A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382:168–171

    PubMed  CAS  Google Scholar 

  • Golombek DA, Biello SM, Rendon RA, Harrington ME (1996) Neuropeptide Y phase shifts the circadian clock in vitro via a Y2 receptor. Neuroreport 7:1315–1319

    PubMed  CAS  Google Scholar 

  • Gregor P, Millham ML, Feng Y et al. (1996) Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett 381:58–62

    PubMed  CAS  Google Scholar 

  • Hackenthal E, Aktories K, Jakobs KH, Lang RE (1987) Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism. Am J Physiol 252:F543–F550

    PubMed  CAS  Google Scholar 

  • Heilig M, Murison R (1987) Intracerebroventricular neuropeptide Y protects against stress-induced gastric erosion in the rat. Eur J Pharmacol 137:127–129

    PubMed  CAS  Google Scholar 

  • Heilig M, Wahlestedt C, Ekman R, Widerlov E (1988) Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain. Eur J Pharmacol 147:465–467

    PubMed  CAS  Google Scholar 

  • Heilig M, Soderpalm B, Engel JA, Widerlov E (1989) Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berlin) 98:524–529

    CAS  Google Scholar 

  • Heilig M, McLeod S, Brot M et al. (1993) Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8:357–363

    PubMed  CAS  Google Scholar 

  • Hellstrom PM, Olerup O, Tatemoto K (1985) Neuropeptide Y may mediate effects of sympathetic nerve stimulations on colonic motility and blood flow in the cat. Acta Physiol Scand 124:613–624

    PubMed  CAS  Google Scholar 

  • Herzog H, Hort YJ, Ball H et al. (1992) Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci USA 89:5794–5798

    PubMed  CAS  Google Scholar 

  • Herzog H, Hort YJ, Shine J, Selbie LA (1993) Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA Cell Biol 12:465–471

    PubMed  CAS  Google Scholar 

  • Hokfelt T, Lundberg JM, Lagercrantz H et al. (1983) Occurrence of neuropeptide Y (NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata. Neurosci Lett 36:217–222

    PubMed  CAS  Google Scholar 

  • Hu Y, Bloomquist BT, Cornfield LJ et al. (1996) Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem 271:26315–26319

    PubMed  CAS  Google Scholar 

  • Hua XY, Boublik JH, Spicer MA et al. (1991) The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship. J Pharmacol Exp Ther 258:243–248

    PubMed  CAS  Google Scholar 

  • Huhman KL, Gillespie CF, Marvel CL, Albers HE (1996) Neuropeptide Y phase shifts circadian rhythms in vivo via a Y2 receptor. Neuroreport 7:1249–1252

    PubMed  CAS  Google Scholar 

  • Inui A, Okita M, Nakajima M et al. (1998) Anxiety-like behavior in transgenic mice with brain expression of neuropeptide Y. Proc Assoc Am Physicians 110:171–182

    PubMed  CAS  Google Scholar 

  • Jazin EE, Yoo H, Blomqvist AG et al. (1993) A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul Pept 47:247–258

    PubMed  CAS  Google Scholar 

  • Kalra SP, Crowley WR (1984) Norepinephrine-like effects of neuropeptide Y on LH release in the rat. Life Sci 35:1173–1176

    PubMed  CAS  Google Scholar 

  • Kalra SP, Fuentes M, Fournier A et al. (1992) Involvement of the Y-l receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats. Endocrinology 130:3323–3330

    PubMed  CAS  Google Scholar 

  • Kanatani A, Mashiko S, Murai N et al. (2000) Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology 141:1011–1016

    PubMed  CAS  Google Scholar 

  • Kassis S, Olasmaa M, Terenius L, Fishman PH (1987) Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein. J Biol Chem 262:3429–3431

    PubMed  CAS  Google Scholar 

  • Kaye WH, Berrettini W, Gwirtsman H, George DT (1990) Altered cerebrospinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa. Arch Gen Psychiatry 47:548–556

    PubMed  CAS  Google Scholar 

  • Klapstein GJ, Colmers WF (1997) Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J Neurophysiol 78:1651–1661

    PubMed  CAS  Google Scholar 

  • Krause J, Eva C, Seeburg PH, Sprengel R (1992) Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol Pharmacol 41:817–821

    PubMed  CAS  Google Scholar 

  • Krstenansky JL, Owen TJ, Buck SH et al. (1989) Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding. Proc Natl Acad Sci USA 86:4377–4381

    PubMed  CAS  Google Scholar 

  • Kushi A, Sasai H, Koizumi H et al. (1998) Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci USA 95:15659–15664

    PubMed  CAS  Google Scholar 

  • Larhammar D, Blomqvist AG, Yee F et al. (1992) Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J Biol Chem 267:10935–10938

    PubMed  CAS  Google Scholar 

  • Larhammar D, Blomqvist AG, Soderberg C (1993) Evolution of neuropeptide Y and its related peptides. Comp Biochem Physiol 106 C:743–752

    Google Scholar 

  • Leibowitz SF, Alexander JT (1991) Analysis of neuropeptide Y-induced feeding: dissociation of Y1 and Y2 receptor effects on natural meal patterns. Peptides 12:1251–1260

    PubMed  CAS  Google Scholar 

  • Leibowitz SF, Xuereb M, Kim T (1992) Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2. Neuroreport 3:1023–1026

    PubMed  CAS  Google Scholar 

  • Levine AS, Morley JE (1984) Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5:1025–1029

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Tatemoto K (1982) Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to alpha-adrenoceptor blockade. Acta Physiol Scand 116:393–402

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Terenius L, Hokfelt T et al. (1982) Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 116:477–480

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Terenius L, Hokfelt T, Goldstein M (1983) High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett 42:167–172

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Stjarne L (1984) Neuropeptide Y (NPY) depresses the secretion of 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens. Acta Physiol Scand 120:477–479

    PubMed  CAS  Google Scholar 

  • Lundell I, Blomqvist AG, Berglund MM et al. (1995) Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J Biol Chem 270:29123–29128

    PubMed  CAS  Google Scholar 

  • MacDonald JK (1988) NPY and related substances. Crit Rev Neurobiol 4:97–135

    Google Scholar 

  • Malmstrom RE (2001) Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y(2) receptor antagonist, in vivo. Br J Pharmacol 133:1073–1080

    PubMed  CAS  Google Scholar 

  • Malmstrom RE, Lundberg JM (1995) Neuropeptide Y accounts for sympathetic vasoconstriction in guinea-pig vena cava: evidence using BIBP 3226 and 3435. Eur J Pharmacol 294:661–668

    PubMed  CAS  Google Scholar 

  • Marksteiner J, Sperk G (1988) Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold. Neuroscience 26:379–385

    PubMed  CAS  Google Scholar 

  • Marksteiner J, Prommegger R, Sperk G (1990) Effect of anticonvulsant treatment on kainic acid-induced increases in peptide levels. Eur J Pharmacol 81:241–246

    Google Scholar 

  • Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD (1998) Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nature Med 4:718–721

    PubMed  CAS  Google Scholar 

  • Marsh DJ, Baraban SC, Hollopeter G, Palmiter RD (1999) Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc Natl Acad Sci USA 96:13518–13523

    PubMed  CAS  Google Scholar 

  • Martel JC, St-Pierre S, Quirion R (1986) Neuropeptide Y receptors in rat brain: autoradiographic localization. Peptides 7:55–60

    PubMed  CAS  Google Scholar 

  • Matsumoto M, Nomura T, Momose K et al. (1996) Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J Biol Chem 271:27217–27220

    PubMed  CAS  Google Scholar 

  • Michel MC, Beck-Sickinger A, Cox H et al. (1998) XVI International union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50:143–150

    PubMed  CAS  Google Scholar 

  • Minth CD, Bloom SR, Polak JM, Dixon JE (1984) Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine. Proc Natl Acad Sci USA 81:4577–4581

    PubMed  CAS  Google Scholar 

  • Minth CD, Andrews PC, Dixon JE (1986) Characterization, sequence, and expression of the cloned human neuropeptide Y gene. J Biol Chem 261:11974–11979

    PubMed  CAS  Google Scholar 

  • Morioka H, Inui A, Inoue T et al. (1986) Neuropeptide Y decreases rectal temperature after intracerebroventricular administration in conscious dogs. Kobe J Med Sci 32:45–57

    PubMed  CAS  Google Scholar 

  • Motulsky HJ, Michel MC (1988) Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells. Am J Physiol 255:E880–885

    Google Scholar 

  • Nakajima M, Inui A, Asakawa A et al. (1998) Neuropeptide Y produces anxiety via Y2-type receptors. Peptides 19:359–363

    PubMed  CAS  Google Scholar 

  • Naveilhan P, Hassani H, Canals JM et al. (1999) Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nature Med 5:1188–1193

    PubMed  CAS  Google Scholar 

  • Naveilhan P, Hassani H, Lucas G et al. (2001) Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Nature 409:513–517

    PubMed  CAS  Google Scholar 

  • Parker RM, Herzog H. (1999) Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci 11:1431–1448

    PubMed  CAS  Google Scholar 

  • Parker EM, Babij CK, Balasubramaniam A et al. (1998) GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Yare potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol 349:97–105

    PubMed  CAS  Google Scholar 

  • Parker E, Van Heek M, Stamford A (2002) Neuropeptide Y receptors as targets for antiobesity drug development: perspective and current status. Eur J Pharmacol 440:173–187

    PubMed  CAS  Google Scholar 

  • Pedrazzini, Seydoux, Kunstner et al. (1998) Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nature Med 4:722–726

    PubMed  CAS  Google Scholar 

  • Petty MA, Dietrich R, Lang RE (1984) The cardiovascular effects of neuropeptide Y (NPY). Clin Exp Hypertens A 6:1889–1892

    PubMed  CAS  Google Scholar 

  • Pheng LH, Regoli D (2000) Receptors for NPY in peripheral tissues bioassays. Life Sci 67:847–862

    PubMed  CAS  Google Scholar 

  • Pralong FP, Gonzales C, Voirol MJ et al. (2002) The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J 16:712–714

    PubMed  CAS  Google Scholar 

  • Raposinho PD, Broqua P, Pierroz DD et al. (1999) Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. Endocrinology 140:4046–4055

    PubMed  CAS  Google Scholar 

  • Rimland J, Xin W, Sweetnam P et al. (1991) Sequence and expression of a neuropeptide Y receptor cDNA. Mol Pharmacol 40:869–875

    PubMed  CAS  Google Scholar 

  • Rimland JM, Seward EP, Humbert Y et al. (1996) Coexpression with potassium channel subunits used to clone the Y2 receptor for neuropeptide Y. Mol Pharmacol 49:387–390

    PubMed  CAS  Google Scholar 

  • Rose PM, Fernandes P, Lynch JS et al. (1995) Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem 270:22661–22664

    PubMed  CAS  Google Scholar 

  • Rudolf K, Eberlein W, Engel W et al. (1994) The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur J Pharmacol 271:R11–13

    Google Scholar 

  • Sainsbury A, Schwarzer C, Couzens M et al. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci USA 99:8938–8943

    PubMed  CAS  Google Scholar 

  • Sheikh SP, O’Hare MM, Tortora O, Schwartz TW (1989) Binding of monoiodinated neuropeptide Y to hippocampal membranes and human neuroblastoma cell lines. J Biol Chem 264:6648–6654

    PubMed  CAS  Google Scholar 

  • Stanley BG, Leibowitz SF (1984) Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci 35:2635–2642

    PubMed  CAS  Google Scholar 

  • Statnick MA, Schober DA, Gackenheimer S et al. (1998) Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites. Brain Res 810:16–26

    PubMed  CAS  Google Scholar 

  • Stephens TW, Basinski M, Bristow PK et al. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530–532

    PubMed  CAS  Google Scholar 

  • Sun XY, Zhao XH, Erlinge D et al. (1996) Effects of phosphorothioated neuropeptide Y Y1-receptor antisense oligodeoxynucleotide in conscious rats and in human vessels. Br J Pharmacol 118:131–136

    PubMed  CAS  Google Scholar 

  • Sundler F, Moghimzadeh E, Hakanson R et al. (1983) Nerve fibers in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Intrinsic and extrinsic origin. Cell Tissue Res 230:487–493

    PubMed  CAS  Google Scholar 

  • Tatemoto K (1982a) Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 79:5485–5489

    PubMed  CAS  Google Scholar 

  • Tatemoto K (1982b) Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 79:2514–2518

    PubMed  CAS  Google Scholar 

  • Tatemoto K (1990) Neuropeptide Y and its receptor antagonist. Ann New York Acad Sci. 611:1–6

    CAS  Google Scholar 

  • Tatemoto K, Mutt V (1978) Chemical determination of polypeptide hormones. Proc Natl Acad Sci USA 75:4115–4119

    PubMed  CAS  Google Scholar 

  • Tatemoto K, Mutt V (1980) Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature 285:417–418

    PubMed  CAS  Google Scholar 

  • Tatemoto K, Carlquist M, Mutt V (1982) Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296:659–660

    PubMed  CAS  Google Scholar 

  • Tatemoto K, Rokaeus A, Jornvall H et al. (1983) Galanin—a novel biologically active peptide from porcine intestine. FEBS Lett 164:124–128

    PubMed  CAS  Google Scholar 

  • Tatemoto K, Lundberg JM, Jornvall H, Mutt V (1985) Neuropeptide K: Isolation, structure and biological activities of a novel brain tachykinin. Biochem Biophys Res Commun 128:947–953

    PubMed  CAS  Google Scholar 

  • Tatemoto K, Efendic S, Mutt V et al. (1986) Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature 324:476–478

    PubMed  CAS  Google Scholar 

  • Terenghi G, Polak JM, Hamid Q et al. (1987) Localization of neuropeptide Y mRNA in neurons of human cerebral cortex by means of in situ hybridization with a complementary RNA probe. Proc Natl Acad Sci USA 84:7315–7318

    PubMed  CAS  Google Scholar 

  • Thiele TE, Marsh DJ, Ste Marie L et al. (1998) Ethanol consumption and resistance are inversely related to NPY levels. Nature 396:366–369

    PubMed  CAS  Google Scholar 

  • Thiele TE, Koh MT, Pedrazzini T (2002) Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor. J Neurosci 22:RC208:l–6

    PubMed  Google Scholar 

  • Thorsell A, Michalkiewicz M, Dumont Y et al. (2000) Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc Natl Acad Sci USA 97:12852–12857

    PubMed  CAS  Google Scholar 

  • Thorsell A, Rimondini R, Heilig M. (2002) Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Neurosci Lett 332:1–4

    PubMed  CAS  Google Scholar 

  • Toufexis DJ, Kyriazis D, Woodside B (2002) Chronic neuropeptide Y Y5 receptor stimulation suppresses reproduction in virgin female and lactating rats. J Neuroendocrinol 14:492–497

    PubMed  CAS  Google Scholar 

  • Unden A, Tatemoto K, Mutt V, Bartfai T (1984) Neuropeptide Y receptor in the rat brain. Eur J Biochem 145: 525–530

    PubMed  CAS  Google Scholar 

  • Vezzani A, Michalkiewicz M, Michalkiewicz T et al. (2002) Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y. Neuroscience 110:237–243

    PubMed  CAS  Google Scholar 

  • Wahlestedt C, Yanaihara N, Hakanson R (1986) Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept 13:307–318

    PubMed  CAS  Google Scholar 

  • Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M (1993) Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259:528–531

    PubMed  CAS  Google Scholar 

  • Watson JD, Sury MR, Corder R et al. (1988) Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations. J Endocrinol 116:421–426

    PubMed  CAS  Google Scholar 

  • Weinberg DH, Sirinathsinghji DJ, Tan CP et al. (1996) Cloning and expression of a novel neuropeptide Y receptor. J Biol Chem 271:16435–16438

    PubMed  CAS  Google Scholar 

  • Westrin A, Ekman R, Traskman-Bendz L (1999) Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt. Eur Neuropsychopharmacol 9:205–211

    PubMed  CAS  Google Scholar 

  • Wharton J, Gordon L, Byrne J et al. (1993) Expression of the human neuropeptide tyrosine Y1 receptor. Proc Natl Acad Sci USA 90:687–691

    PubMed  CAS  Google Scholar 

  • Widerlov E, Lindstrom LH, Wahlestedt C, Ekman R (1988) Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively. J Psychiatr Res 22:69–79

    PubMed  CAS  Google Scholar 

  • Woldbye DP, Larsen PJ, Mikkelsen JD et al. (1997) Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nature Med 3:761–764

    Google Scholar 

  • Yan H, Yang J, Marasco J et al. (1996) Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc Natl Acad Sci USA 93:4661–4665

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Molecular Physiology, Institute for Molecular and Cellular Regulation, Gunma University, 371-8512, Maebashi, Japan

    K. Tatemoto

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  1. K. Tatemoto
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  1. Afd. Farmacologie & Farmacotherapie, Academisch Medisch Centrum, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    Martin C. Michel

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© 2004 Springer-Verlag Berlin Heidelberg

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Tatemoto, K. (2004). Neuropeptide Y: History and Overview. In: Michel, M.C. (eds) Neuropeptide Y and Related Peptides. Handbook of Experimental Pharmacology, vol 162. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18764-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-18764-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62282-3

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