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Biological Effects of Estrogen on Skin

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Textbook of Aging Skin

Abstract

Changes in skin aging and function occur at variable rates, and are influenced by environmental, hormonal, and genetic factors unique to each individual. Skin aging involves progressive degenerative changes, such as gradual dryness, thinning, fragility, atrophy, and wrinkling. Over time, the skin experiences a progressive increase in extensibility and a reduction in elasticity, thereby becoming more frail and susceptible to trauma. This in turn leads to an increased risk of skin injury (e.g., lacerations, tears, ulcerations, bruising), and an impairment of wound healing.

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References

  1. World Health Organization Fact Sheet Number 252. http://www.who.int/mediacentre/factsheets/fs252/en/. June 2000.

  2. Censtral Intelligence Agency. The World Fact Book. https://www.cia.gov/library/publications/the-world-factbook/geos/US.html. Updated Apr 30, 2009.

  3. Women, Ageing and Health: A Framework for Action. World Health Organization. http://www.who.int/ageing/publications/Women-ageing-health-lowres.pdf. 2007.

  4. Shah M, Maibach H. Estrogen and skin, an overview. Am J Clin Dermatol. 2001;2(3):143.

    CAS  PubMed  Google Scholar 

  5. Palacios S. Current perspectives on the benefits of HRT in menopausal women. Maturitas. 1999;33:S1–S3.

    CAS  PubMed  Google Scholar 

  6. HRT/ERT refers to supplements of hormones, such as estrogen or estrogen with progesterone (progestin in its synthetic form). ERT will be used going forward to prevent confusion with other hormone therapies.

    Google Scholar 

  7. King, M. The Medical Biochemistry Page. IU School of Medicine. http://themedicalbiochemistrypage.org/extracellularmatrix.html. Last modified June 11, 2008.

  8. Bullough HF. Cyclical changes in the skin of the mouse during estrous cycle. J Endocrinol. 1943;3:280–287.

    Google Scholar 

  9. McConkey B, Fraser GM, Bligh AS, et al. Transparent skin and osteoporosis. Lancet. 1963;I:693–695.

    Google Scholar 

  10. Black MM, Bottoms E, Shuster S. Changes in skin collagen and thickness in endocrine disease. Eur J Clin Invest. 1970;1:127.

    Google Scholar 

  11. Meema HE, Sheppard RH, Rapoport A. Roentgenographic visualization and measurement of skin thickness and its diagnostic application in acromegaly. Radiology. 1964;82:411.

    CAS  PubMed  Google Scholar 

  12. Rauramo L, Punnomen R. Wirkung einer oralen ostrogenotherapie mit ostriolsuccinat auf die Hautt kastrierter Frauen. Z Haut Geschl Kr. 1969;44:463–470.

    CAS  Google Scholar 

  13. Brincat M, Yuen AW, Studd JW, et al. Response of skin thickness and metacarpal index to estradiol therapy in postmenopausal women. Obstet Gynecol. Oct 1987;70(4):538–541.

    CAS  Google Scholar 

  14. Castelo-Branco C, Duran M, Gonzales-Merlo J. Skin collagen and bone changes related to age and hormone replacement therapy. Maturitas. 1992;14:113–119.

    Google Scholar 

  15. Affinito P, Palomba S, Sorrentino C, et al. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas. 1999;33:239–247.

    CAS  PubMed  Google Scholar 

  16. Phillips TJ, Symons J, et al. Does hormone therapy improve age-related skin changes in postmenopausal women? A randomized, double-blind, double-dummy, placebo-controlled multicenter study assessing the effects of norethindrone acetate and ethinyl estradiol in the improvement of mild to moderate age-related skin changes in postmenopausal women. J Am Acad Dermatol. Sept 2008;59(3):397–404, e3.

    Google Scholar 

  17. Haapasari K, Raudaskoski T, Kallioinen M, et al. Systemic therapy with estrogen or estrogen with progestin has no effect on skin collagen in postmenopausal women. Maturitas. 1997;27:153–162.

    Google Scholar 

  18. Maheux R, Naud F, Rioux M, et al. A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol. 1994;170:642–649.

    CAS  PubMed  Google Scholar 

  19. Varila E, Rantala I, Oikarinen A, et al. The effect of topical estradiol on skin collagen of postmenopausal women. Br J Obstet Gynaecol. Dec 1995;102(12):985–989.

    CAS  Google Scholar 

  20. Callens A, Valliant L, Lecomte P, et al. Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology. 1996;193:289–294.

    CAS  PubMed  Google Scholar 

  21. Sauerbronn AVD, Fonseca AM, Bagnoli VR, et al. The effects of systemic hormone replacement therapy on the skin of the postmenopausal women. Int J Gynecol Obstet. 2000;68:35–41.

    CAS  Google Scholar 

  22. Sator PG, Sator MO, Schmidt JB, et al. A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women. Climacteric. 2007;10:320–334.

    CAS  PubMed  Google Scholar 

  23. Sumino H, Ichikawa S, et al. Effects of aging, menopause, and hormone replacement therapy on forearm skin elasticity in women. J Am Geriatr Soc. 2004;52:945–949.

    PubMed  Google Scholar 

  24. Savvas M, Laurent G. Type III collagen content in the skin of postmenopausal women receiving estradiol and testosterone implants. Br J Obstet Gynaecol. Feb 1993;100:154–156.

    CAS  PubMed  Google Scholar 

  25. Lee JY, Maibach HI. Corticosteroid skin atrophogenicity: assessment methods. Skin Res Technol. 1998;4:161–166.

    CAS  Google Scholar 

  26. Schmidt J, Binder M, Demschik G, et al. Treatment of skin aging with topical estrogens. Int J Dermatol. 1996;35:669–674.

    CAS  PubMed  Google Scholar 

  27. Dunn L, Damesyn M, Moore A, et al. Does estrogen prevent skin aging? Results from the First National Health and Nutritional Examination Survey. Arch Dermatol. 1997;133:339–342.

    CAS  PubMed  Google Scholar 

  28. Grosman N, Hridbey E, Schon J. The effect of estrogenic treatment on the acid mucopolysaccharide pattern in the skin of mice. Acta Pharmacol Toxicol. 1971;30:458–464.

    CAS  Google Scholar 

  29. Grosman N. Studies on the hyaluronic acid protein complex the molecular size of hyaluronic acid and the exchangeability of chloride in skin of mice before and after estrogen treatment. Acta Pharmacol Toxicol. 1973;33:201–208.

    CAS  Google Scholar 

  30. Pochi PE, Strauss JS, Downing D. Age related changes in sebaceous gland activity. J Invest Dermatol. 1979;73:108–111.

    CAS  PubMed  Google Scholar 

  31. Pierard-Franchimont C, Letawe C, Goffin V, et al. Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study. Maturitas. 1995;22:151–154.

    CAS  PubMed  Google Scholar 

  32. Paquet F, Pierard-Franchimont C, Fuman I, et al. Sensitive skin at menopause; dew point and electrometric properties of the stratum corneum. Maturitas. 1998;28:221–227.

    CAS  PubMed  Google Scholar 

  33. Sumino H, Ichikawa S, Abe M, et al. Effects of aging and postmenopausal hypoestrogenism on skin elasticity and bone mineral density in Japanese women. Endocrine J. 2004;51:159–164.

    CAS  Google Scholar 

  34. Contet-Audonneau JL, Jeanmaire C, Pauly G. A histological study of human wrinkle structures: comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas. Br J Dermatol. 1999;140:1038–1047.

    CAS  PubMed  Google Scholar 

  35. Bosset S, Barre P, Chalon A, et al. Skin ageing: clinical and histopathologic study of permanent and reducible wrinkles. Eur J Dermatol. 2002;12(3):247–252.

    PubMed  Google Scholar 

  36. Creidi P, Faivre B, Agache P, et al. Effect of a conjugated estrogen (Premarin) cream on ageing facial skin. A comparative study with a placebo cream. Maturitas. 1994;19:211–223.

    CAS  PubMed  Google Scholar 

  37. Punnonen R, Vaajalahti P, Teisala K. Local estriol treatment improves the structure of elastic fibers in the skin of postmenopausal women. Ann Chir Gynaecol. 1987;202(Suppl):39–41.

    CAS  Google Scholar 

  38. Castelo-Branco C, Figueras F, Martinez de Osaba M, et al. Facial wrinkling in postmenopausal women. Effects of smoking status and hormone replacement therapy. Maturitas. 1998;29:75–86.

    CAS  PubMed  Google Scholar 

  39. Brincat MP, Muscat Baron Y, Galea R. Estrogens and the skin. Climacteric. 2005;8:110–123.

    CAS  PubMed  Google Scholar 

  40. Ashcroft GS, Dodsworth J, van Boxtel E, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels. Nat Med. 1997;3:1209–1215.

    CAS  PubMed  Google Scholar 

  41. Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol. 1999;155:1137–1146.

    CAS  PubMed  Google Scholar 

  42. Ashcroft GS, Ashworth JJ. Potential role of estrogens in wound healing. Am J Clin Dermatol. 2003;4(11):737–743.

    PubMed  Google Scholar 

  43. Whitby DJ, Ferguson MWJ. Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol. 1991;147:207–215.

    CAS  PubMed  Google Scholar 

  44. Shah M, Foreman DM, Ferguson MWJ. Control of scarring in adult wounds by neutralizing antibody to transforming growth factor B. Lancet. 1992;339:213–214.

    CAS  PubMed  Google Scholar 

  45. Hu D, Hughes MA, Cherry GW. Topical tamoxifen – a potential therapeutic regime in treating excessive dermal scarring? Br J Plast Surg. Sept 1998;51(6):462–469.

    CAS  Google Scholar 

  46. Surazynski A, Jarzabek K, Haczynski J, Laudanski P, Palka J, Wolczynski S. Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts. Int J Mol Med. 2003;12:803–809.

    CAS  PubMed  Google Scholar 

  47. Osborne K, Zhao HH, Fuqua SAW. Selective estrogen receptor modulators: structure, function, and clinical use. J Clin Oncol. 2000;18:3172–3186.

    CAS  PubMed  Google Scholar 

  48. Hall GK, Phillips TJ. Skin and hormone therapy. Clin Obstet Gynecol. 2004;47(2):437–449.

    PubMed  Google Scholar 

  49. Kanda N, Watanabe S. Regulatory roles of sex hormones in cutaneous biology and immunology. J Dermatol Sci. 2005;38(1):1–7.

    CAS  PubMed  Google Scholar 

  50. Schmidt JB. Perspectives of estrogen treatment in skin aging. Exp Dermatol. 2005;14(2):156.

    Google Scholar 

  51. Thornton MJ. Estrogen functions in skin and skin appendages. Expert Opin Ther Targets. 2005;9(3):617–629.

    CAS  PubMed  Google Scholar 

  52. Lynfield YL. Effect of pregnancy on the human hair cycle. J Invest Dermatol. 1960;35:323–327.

    CAS  PubMed  Google Scholar 

  53. Whiting DA. Diagnosis of Alopecia. Current Concepts. Kalamazoo: A Scope Publication, The Upjohn, 1990.

    Google Scholar 

  54. Burger H. Hormone replacement therapy in the post-Women's Health Initiative era. Report of a meeting held in Funchal, Madeira, February 24–25. Climacteric. 2003;6(Suppl 1):11–36.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. University of California, San Francisco, 2901 Cityplace West Blvd., Apt. 442, Dallas, TX, 75204-0360, USA

    Zack Thompson

  2. University of California, San Francisco, CA, 94143-0989, USA

    Howard I. Maibach

Authors
  1. Zack Thompson
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  2. Howard I. Maibach
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Editor information

Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

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© 2010 Springer-Verlag Berlin Heidelberg

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Thompson, Z., Maibach, H.I. (2010). Biological Effects of Estrogen on Skin. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_35

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  • DOI: https://doi.org/10.1007/978-3-540-89656-2_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine

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