Synonyms
Basement membrane
Definition
The basal lamina is a thin layer of extracellular matrix covering the connective tissue surface of Schwann cells, muscle fibers and epithelial cells in general. The main structural component of basal lamina is type IV collagen, with which heparan sulfate proteoglycans and laminin, a major adhesion molecule, are associated. Regenerating axons grow through basal lamina tubes derived from Schwann cells, skeletal muscle fibers and other tissues. This means that extracellular matrices such as basal laminae can serve as an effective scaffold for the growth of regenerating axons.
Characteristics
Axonal Growth Through the Nerve Segments of Wallerian Degeneration
The peripheral nerve fiber consists of axons and Schwann cells. Schwann cells cover axons along their entire length except at the node of Ranvier, where a gap is formed between the neighboring Schwann cells. In addition, Schwann cells are covered on their outer surfaces by basal laminae that are...
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References
Ide C, Tohyama K, Yokota R, Nitatori T, Onodera S (1983) Schwann cell basal lamina and nerve regeneration. Brain Res 288:61–75
Fujimoto E, Mizoguchi A, Hanada K, Yajima M, Ide C (1997) Basic fibroblast growth factor promotes extension of regenerating axons of peripheral nerve. In vivo experiments using a Schwann cell basal lamina tube model. J Neurocytol 26:511–528
Chen ZL, Strickland S (2003) Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve. J Cell Biol 163:889–899
Gardiner NJ, Fernyhough P, Tomlinson DR, Mayer U, Mark H, von der Streuli CH (2003) Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons. Mol Cell Neurosci 28:229–240
Ekstrom PA, Mayer U, Panjwani A, Pountney D, Pizzy J, Tonge DA Involvement of α7β1 integrin in the conditioning-lesion effects on sensory axons regeneration. Mol Cell Neurosci 22:383–395
Vogelezang MG, Liu Z, Relvas JB, Raivich G, Scherer SS, ffrench-Constant C (2001) Alpha4 integrin is expressed during peripheral nerve regeneration and enhances neurite outgrowth. J Neurosci 21:6732–6744
Dubovy P (2004) Schwann cells and endoneurial extracellular matrix molecules as potential cues for sorting of regenerated axons: a review. Anat Sci Int 79:198–208
Ide C (1984) Nerve regeneration through the basal lamina scaffold of the skeletal muscle. Neurosci Res 1:379–391
Ide C, Tohyama K, Tajima K, Mizoguchi A (1998) Long acellular nerve transplants for allogeneic grafting and the effects of basic fibroblast growth factor on the growth of regenerating axons in dogs. Exp Neurol 154:99–112
Ide C, Kato S (1990) Peripheral nerve regeneration. Neurosci Res (Suppl 13):S157–S164
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© 2008 Springer-Verlag GmbH Berlin Heidelberg
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Ide, C. (2008). Basal Lamina in Nerve Regeneration. In: Binder, M.D., Hirokawa, N., Windhorst, U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29678-2_564
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DOI: https://doi.org/10.1007/978-3-540-29678-2_564
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Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-540-29678-2
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