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Efflux-Mediated Antimicrobial Resistance in Bacteria pp 651–663Cite as

The Relationship Between Bacterial Multidrug Efflux Pumps and Biofilm Formation

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Abstract

Multidrug efflux pumps are present in all bacterial species and are known to be important in determining antimicrobial resistance. They are also important contributors to the pathogenicity of many species. Recently a link between multidrug efflux and the ability to form a biofilm has been identified in various species. Biofilm formation is thought to play a role in the majority of infections and bacteria within a biofilm are often highly antimicrobial resistant. Whilst the genes required for biofilm formation vary between species, those which are involved in production of the components of the extracellular matrix which is a hallmark feature of biofilms are crucial. In this chapter, the evidence that links multidrug resistance efflux pumps with a role in biofilm formation is reviewed, and the possible utility of efflux inhibitors as anti-biofilm compounds is discussed.

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Author information

Authors and Affiliations

  1. Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK

    Alexander Fahmy, Ananth Srinivasan & Mark A. Webber

Authors
  1. Alexander Fahmy
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  2. Ananth Srinivasan
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  3. Mark A. Webber
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Corresponding author

Correspondence to Mark A. Webber .

Editor information

Editors and Affiliations

  1. Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada

    Xian-Zhi Li

  2. U.S. Food and Drug Administration, Laurel, Maryland, USA

    Christopher A. Elkins

  3. University of Oklahoma, Norman, Oklahoma, USA

    Helen I. Zgurskaya

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© 2016 Springer International Publishing Switzerland

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Fahmy, A., Srinivasan, A., Webber, M.A. (2016). The Relationship Between Bacterial Multidrug Efflux Pumps and Biofilm Formation. In: Li, XZ., Elkins, C., Zgurskaya, H. (eds) Efflux-Mediated Antimicrobial Resistance in Bacteria. Adis, Cham. https://doi.org/10.1007/978-3-319-39658-3_25

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