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Behavioural and physiological effects of electrical stimulation in the nucleus accumbens: a review

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Operative Neuromodulation

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 97/2))

Abstract

Electrical stimulation (ES) in the brain is becoming a new treatment option in patients with treatment-resistant obsessive-compulsive disorder (OCD). A possible brain target might be the nucleus accumbens (NACC). This review aims to summarise the behavioural and physiological effects of ES in the NACC in humans and in animals and to discuss these findings with regard to neuroanatomical, electrophysiological and behavioural insights. The results clearly demonstrate that ES in the NACC has an effect on reward, activity, fight-or-flight, exploratory behaviour and food intake, with evidence for only moderate physiological effects. Seizures were rarely observed. Finally, the results of ES studies in patients with treatment-resistant OCD and in animal models for OCD are promising.

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Authors and Affiliations

  1. Department of Neuroscience and Psychiatry, Laboratory of Experimental Neurosurgery and Neuroanatomy, Leuven, Belgium

    K. van Kuyck & Bart Nuttin

  2. Department of Psychiatry, University Hospital Antwerpen, Edegem, Belgium

    L. Gabriëls & P. Cosyns

  3. Department of Biology, Laboratory of Neuroplasticity and Neuroproteomics, Leuven, Belgium

    L. Arckens

  4. Department of Stereotaxy and Functional Neurosurgery, Medical University of Cologne, Cologne, Germany

    V. Sturm

  5. Butler Hospital and Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island, USA

    S. Rasmussen

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  1. K. van Kuyck
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  2. L. Gabriëls
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  3. P. Cosyns
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  4. L. Arckens
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  5. V. Sturm
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  6. S. Rasmussen
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  7. Bart Nuttin
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Correspondence to Bart Nuttin .

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Editors and Affiliations

  1. Department of Neurosurgery, University of Athens, Athens, Greece

    Damianos E. Sakas

  2. University Hospital of Wales, Cardiff, UK

    Brian A. Simpson

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van Kuyck, K. et al. (2007). Behavioural and physiological effects of electrical stimulation in the nucleus accumbens: a review. In: Sakas, D.E., Simpson, B.A. (eds) Operative Neuromodulation. Acta Neurochirurgica Supplements, vol 97/2. Springer, Vienna. https://doi.org/10.1007/978-3-211-33081-4_43

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