Summary
It has become increasingly clear that the so-called ‘drug-metabolizing enzymes,’ and the receptors controlling them, play a key role in regulating the steady-state levels of ligands important in the transcription of genes involved in cell division, differentiation, apoptosis, homeostasis, and neuroendocrine functions. In this Chapter is presented an example of the possible role of the high-affinity Ah receptor in protection against ethanol-induced inflammation by way of the arachidonic acid cascade. Ethanol consumption is associated with cancer, inflammation, birth defects, and other toxic effects. Ethanol-induced toxicity appears to be mediated by many of the same oxidative stress signal transduction pathways used by other tumor promoters, teratogens, mitogens and comitogens.
Keywords
- Arachidonic Acid
- Endogenous Ligand
- Fetal Alcohol Syndrome
- Arachidonic Acid Metabolite
- Arachidonic Acid Release
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1994 Birkhäuser Verlag Basel/Switzerland
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Nebert, D.W. (1994). Drug metabolism and signal transduction: Possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_23
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DOI: https://doi.org/10.1007/978-3-0348-7330-7_23
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