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Discovering New Natural Products Using Metabolomics-Based Approaches

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Microbial Natural Products Chemistry

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1439))

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Abstract

The incessant search for new natural molecules with biological activities has forced researchers in the field of chemistry of natural products to seek different approaches for their prospection studies. In particular, researchers around the world are turning to approaches in metabolomics to avoid high rates of re-isolation of certain compounds, something recurrent in this branch of science. Thanks to the development of new technologies in the analytical instrumentation of spectroscopic and spectrometric techniques, as well as the advance in the computational processing modes of the results, metabolomics has been gaining more and more space in studies that involve the prospection of natural products. Thus, this chapter summarizes the precepts and good practices in the metabolomics of microbial natural products using mass spectrometry and nuclear magnetic resonance spectroscopy, and also summarizes several examples where this approach has been applied in the discovery of bioactive molecules.

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Authors and Affiliations

  1. Grupo de Pesquisas LaBiORG – Laboratório de Química Bio-orgânica Otto Richard Gottlieb, Universidade Federal de São Paulo, Diadema, Brazil

    Lívia Soman de Medeiros, Milena Costa Bassicheto, Giordanno Di Gioia & Thiago André Moura Veiga

  2. Grupo de Pesquisa em Metabolômica e Espectrometria de Massas, Universidade do Estado do Amazonas, Manaus, Brazil

    Moysés B. de Araújo Júnior, Eldrinei G. Peres, José Carlos Ipuchima da Silva & Hector Henrique Ferreira Koolen

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  1. Lívia Soman de Medeiros
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  2. Moysés B. de Araújo Júnior
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  3. Eldrinei G. Peres
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  4. José Carlos Ipuchima da Silva
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  5. Milena Costa Bassicheto
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  6. Giordanno Di Gioia
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  7. Thiago André Moura Veiga
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  8. Hector Henrique Ferreira Koolen
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Correspondence to Lívia Soman de Medeiros .

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  1. Institute of Chemistry, Universidade Estadual de Campinas, Campinas, Brazil

    Taícia Pacheco Fill

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de Medeiros, L.S. et al. (2023). Discovering New Natural Products Using Metabolomics-Based Approaches. In: Pacheco Fill, T. (eds) Microbial Natural Products Chemistry. Advances in Experimental Medicine and Biology(), vol 1439. Springer, Cham. https://doi.org/10.1007/978-3-031-41741-2_8

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