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Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration

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Cardiac Mechanobiology in Physiology and Disease

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 9))

Abstract

Over the past decades, huge scientific efforts have been put into cardiac regeneration strategies. Although several strategies have been accepted for use in clinical practice, none has demonstrated great success in regenerating the cardiac tissue. Therefore, there are still significant challenges in repairing or regenerating cardiac tissue, which serves a predominantly biomechanical function. Furthermore, it is now evident that the mechanobiological interaction between cells and their mechanical environment is essential for tissue function and regeneration. Current cardiac regenerative strategies (i.e. cardiac cell therapy and tissue engineering) are based on administrating new healthy contractile cells within (or without) a healthy scaffold into the diseased cardiac environment. However, these strategies have widely omitted to restore the cellular mechanical environment present after cardiac injury. Therefore, the future cardiac regeneration strategies need to address the challenges of and questions on the role of biomechanics and mechanobiology in cardiac regeneration. This includes measurement and characterisation of multiscale mechanical properties of healthy and diseased cardiac tissue; development of in vitro and in silico models to understand the role of biomechanical factors in tissue regeneration; and translation of this information into the design of novel tissue-engineered strategies. In this chapter, we want to introduce the reader to the importance of mechanical considerations in the design of effective cardiac regeneration strategies.

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Notes

  1. 1.

    Living Heart Project | SIMULIA™ - Dassault Systèmes® (3ds.com)| SIMULIA™ - Dassault Systèmes® (3ds.com).

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Acknowledgements

The authors would like to thank Gemma Burcet, MD from Hospital Universitari Vall d’Hebron and Institut de Diagnòstic per la Imatge (Barcelona, Spain), for the supply of magnetic resonance images and strain processing. This work is supported by the partners of ‘Regenerative Medicine Crossing Borders’ (RegMed XB) and by Health~Holland, Top Sector Life Sciences & Health. We also gratefully acknowledge funding from the Ministry of Education, Culture and Science for the Gravitation Program 024.003.103 ‘Materials-Driven Regeneration’ and Nederlandse Organisatie voor Wetenschappelijk Onderzoek for the NWO Open Competition Domain Science grant, OCENW.XS21.4.146.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

    Ignasi Jorba, Milica Nikolic & Carlijn V. C. Bouten

  2. Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands

    Ignasi Jorba, Milica Nikolic & Carlijn V. C. Bouten

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  1. Ignasi Jorba
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  2. Milica Nikolic
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  3. Carlijn V. C. Bouten
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Correspondence to Carlijn V. C. Bouten .

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Editors and Affiliations

  1. Department of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany

    Markus Hecker

  2. Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    Dirk J. Duncker

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Funding: This work was funded by 1) the partners of ‘Regenerative Medicine Crossing Borders’ and Health~Holland, Top Sector Life Sciences & Health (project Cardiac Moonshot), 2) the Ministry of Education, Culture and Science for the Gravitation Program ‘Materials-Driven Regeneration’ (grant number 024.003.103), and 3) by the Dutch Research Council (OCENW.XS21.4.146).

Conflict of Interest: All authors declare they have no conflict of interest.

Ethical Approval: This chapter does not contain any studies with animals performed by any of the authors. For Fig. 2d, g informed consent was obtained from the patients.

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Jorba, I., Nikolic, M., Bouten, C.V.C. (2023). Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration. In: Hecker, M., Duncker, D.J. (eds) Cardiac Mechanobiology in Physiology and Disease. Cardiac and Vascular Biology, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-031-23965-6_8

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