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Anticholinesterase, Antidiabetic and Anti-inflammatory Activity of Secondary Metabolites of Teucrium Species

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Teucrium Species: Biology and Applications

Abstract

The chapter reviews the data about anticholinesterase, antidiabetic, and anti-inflammatory activity of the active substances from Teucrium species. Extracts and essential oils from the species of Teucrium genus possess a wide range of secondary metabolites that exhibit biological activity. Discussed examinations are focused on the determination of the qualitative and quantitative composition of the active substances from Teucrium species, as well as the anticholinesterase, antidiabetic and anti-inflammatory activity. Many authors state that Alzheimer’s disease, diabetes mellitus, and inflammatory diseases correlate because they are precursors of neurodegenerative diseases. Secondary metabolites isolated from plants of the genus Teucrium have been shown to be potential inhibitors of acetylcholinesterase. Also, examined metabolites possess antihyperglycemic activity and reduce blood glucose levels. Extracts of the species from the genus Teucrium exhibit anti-inflammatory activity in in vitro and in vivo conditions by inhibiting carrageenan-induced inflammation and significantly reduced serum levels of triglyceride and cholesterol. As a result, it has been shown that the species of the genus Teucrium are rich in compounds such as flavonoids, phenolic acids and terpenoids that directly contribute to anticholinesterase, antidiabetic and anti-inflammatory activity. Species of the genus Teucrium are good candidates for further examination in order to the treatment of the previously mentioned disorders.

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Abbreviations

ACh:

Acetylcholine

AChE:

Acetylcholinesterase

AChI:

Acetylcholine iodide

AD:

Alzheimer’s disease

COX:

Cyclooxygenase

DTNB:

5,5-dithio-bis-2-nitrobenzoic acid

FDA:

Food and drug administration

HLA:

Human leukocyte antigen

IC50:

Half maximal inhibitory concentration

iNOS:

Inducible nitric oxide synthase

LDL:

Low density lipoproteins

mRNA:

Messenger ribonucleic acid

NO:

Nitric oxide

STZ:

Single dose streptozotocin

TNB:

2-nitro-5-mercaptobenzoic acid

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  1. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, Serbia

    Nenad Zlatić & Milan Stanković

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    Milan Stanković

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Zlatić, N., Stanković, M. (2020). Anticholinesterase, Antidiabetic and Anti-inflammatory Activity of Secondary Metabolites of Teucrium Species. In: Stanković, M. (eds) Teucrium Species: Biology and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-52159-2_14

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