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Drosophila Model in Cancer: An Introduction

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The Drosophila Model in Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1167))

Abstract

Cancer is a cumulative manifestation of several complicated disease states that affect multiple organs. Over the last few decades, the fruit fly Drosophila melanogaster, has become a successful model for studying human cancers. The genetic simplicity and vast arsenal of genetic tools available in Drosophila provides a unique opportunity to address questions regarding cancer initiation and progression that would be extremely challenging in other model systems. In this chapter we provide a historical overview of Drosophila as a model organism for cancer research, summarize the multitude of genetic tools available, offer a brief comparison between different model organisms and cell culture platforms used in cancer studies and briefly discuss some of the latest models and concepts in recent Drosophila cancer research.

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Acknowledgements

We thank G. Calvin, D. Corcoran, J. Kennedy, E. Lee, J. Poulton, and G. Xie for critical reading of the manuscript. W.-M.D. is supported by Florida Department of Health 8 BC12, National Science Foundation IOS-1052333, and National Institutes of Health R01GM072562 and R01CA224381.

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  1. Department of Biochemistry and Molecular Biology, Tulane Cancer Center, LCRC, Tulane University School of Medicine, New Orleans, LA, USA

    Deeptiman Chatterjee & Wu-Min Deng

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    Wu-Min Deng

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Chatterjee, D., Deng, WM. (2019). Drosophila Model in Cancer: An Introduction. In: Deng, WM. (eds) The Drosophila Model in Cancer. Advances in Experimental Medicine and Biology, vol 1167. Springer, Cham. https://doi.org/10.1007/978-3-030-23629-8_1

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