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HPV-Associated Anal Cancer in the HIV/AIDS Patient

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HIV/AIDS-Associated Viral Oncogenesis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 177))

Abstract

The prevalence of anal human papillomavirus (HPV) infection and anal high-grade squamous intraepithelial lesion (HSIL) remain high among HIV-infected individuals on effective antiretroviral therapy (ART). The incidence of HPV-related anal cancers has continued to increase since the introduction of ART. Therefore, ART may confer only limited benefit with respect to reducing the risk of anal HSIL and cancer. Efforts are in progress to define the efficacy of secondary prevention programs for prevention of anal cancer. In the modern ART era, anal cancer recurrence and survival outcomes are similar in HIV-infected and HIV-uninfected patients, but HIV-infected patients may experience more toxicities. This article reviews the current literature on HPV-associated anal cancer in the HIV-infected population, including epidemiology, screening, clinical characteristics, and treatment outcomes.

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Acknowledgments

Dr. Wang has no relevant disclosures.

Dr. Palefsky discloses that he is a member of a Merck scientific advisory board, and receives travel support form Merck. He receives travel and research grant support from Merck. He is a consultant to Ubiome, Agenovir, and Antiva Biosciences.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA

    Chia-Ching J. Wang

  2. Division of Infectious Diseases, Department of Medicine, University of California at San Francisco, San Francisco, CA, USA

    Joel M. Palefsky

  3. 995 Potrero Avenue, Building 80, 4th Floor, San Francisco, CA, 94110, USA

    Chia-Ching J. Wang

  4. 513 Parnassus Ave, Med Sci Room 420E, Box 0654, San Francisco, CA, 94143, USA

    Joel M. Palefsky

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  1. Chia-Ching J. Wang
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  2. Joel M. Palefsky
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Correspondence to Joel M. Palefsky .

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  1. Penn State Cancer Institute, Penn State University, Hershey, PA, USA

    Craig Meyers

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Wang, CC.J., Palefsky, J.M. (2019). HPV-Associated Anal Cancer in the HIV/AIDS Patient. In: Meyers, C. (eds) HIV/AIDS-Associated Viral Oncogenesis. Cancer Treatment and Research, vol 177. Springer, Cham. https://doi.org/10.1007/978-3-030-03502-0_7

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