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Cancer Nanotechnology pp 67–81Cite as

Multimodal Nanoparticulate Bioimaging Contrast Agents

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 624))

Abstract

A wide variety of bioimaging techniques (e.g., ultrasound, computed X-ray tomography, magnetic resonance imaging (MRI), and positron emission tomography) are commonly employed for clinical diagnostics and scientific research. While all of these methods use a characteristic “energy–matter” interaction to provide specific details about biological processes, each modality differs from another in terms of spatial and temporal resolution, anatomical and molecular details, imaging depth, as well as the desirable material properties of contrast agents needed for augmented imaging. On many occasions, it is advantageous to apply multiple complimentary imaging modalities for faster and more accurate prognosis. Since most imaging modalities employ exogenous contrast agents to improve the signal-to-noise ratio, the development and use of multimodal contrast agents is considered to be highly advantageous for obtaining improved imagery from sought-after imaging modalities. Multimodal contrast agents offer improvements in patient care, and at the same time can reduce costs and enhance safety by limiting the number of contrast agent administrations required for imaging purposes. Herein, we describe the synthesis and characterization of nanoparticulate-based multimodal contrast agent for noninvasive bioimaging using MRI, optical, and photoacoustic tomography (PAT)-imaging modalities. The synthesis of these agents is described using microemulsions, which enable facile integration of the desired diversity of contrast agents and material components into a single entity.

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Acknowledgments

The authors acknowledge the financial support of the Particle Engineering Research Center (PERC) at the University of Florida, the National Science Foundation (NSF Grant EEC-94-02989, NSF-NIRT Grant EEC-0506560), the National Institute of Health (RO1HL75258, R01HL78670), James and Esther King Biomedical Research Program (Grant 06NIR-05), Patricia Adams Cancer Nanotechnology Research Fund, and the Industrial Partners of the PERC for support of his research. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect those of the National Science Foundation. NMR (MRI) data were obtained at the Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) facility in the McKnight Brain Institute of the University of Florida. P.S. acknowledges Principal, St. Stephen’s College, Delhi, India, for granting leave for research.

Author information

Authors and Affiliations

  1. Department of Materials Science and Engineering, Particle Engineering Research Center, University of Florida, Gainesville, FL, USA

    Parvesh Sharma, Amit Singh, Scott C. Brown & Brij M. Moudgil

  2. Department of Molecular Genetics and microbiology, University of Florida, Gainesville, FL, USA

    Parvesh Sharma, Niclas Bengtsson & Edward W. Scott

  3. Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA

    Glenn A. Walter

  4. Division of Surgical Oncology, Department of Surgery, University of Florida, Gainesville, FL, USA

    Stephen R. Grobmyer & Nobutaka Iwakuma

  5. Department of Chemistry and Biomolecular Science Center, NanoScience Technology Center, University of Central Florida, Orlando, FL, USA

    Swadeshmukul Santra

Authors
  1. Parvesh Sharma
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  2. Amit Singh
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  3. Scott C. Brown
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  4. Niclas Bengtsson
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  5. Glenn A. Walter
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  6. Stephen R. Grobmyer
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  7. Nobutaka Iwakuma
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  8. Swadeshmukul Santra
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  9. Edward W. Scott
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  10. Brij M. Moudgil
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Editor information

Editors and Affiliations

  1. Dept. Surgery, University of Florida, Gainesville, USA

    Stephen R. Grobmyer

  2. ERC - Engineering Research Center, University of Florida, Gainesville, USA

    Brij M. Moudgil

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Sharma, P. et al. (2010). Multimodal Nanoparticulate Bioimaging Contrast Agents. In: Grobmyer, S., Moudgil, B. (eds) Cancer Nanotechnology. Methods in Molecular Biology, vol 624. Humana Press. https://doi.org/10.1007/978-1-60761-609-2_5

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  • DOI: https://doi.org/10.1007/978-1-60761-609-2_5

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-608-5

  • Online ISBN: 978-1-60761-609-2

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