Abstract
In the analysis of experimental data corresponding to the signal enrichment of chromatin features such as histone modifications throughout the genome, it is often useful to represent the signal over known regions of interest, such as genes, using aggregate or individual profiles. In the present chapter, we describe and explain the best practices on how to generate such profiles as well as other usages of the versatile aggregate profiler (VAP) tool (Coulombe et al., Nucleic Acids Res 42:W485–W493, 2014), with a particular focus on the new functionalities introduced in version 1.1.0 of VAP.
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Brunelle, M. et al. (2015). Aggregate and Heatmap Representations of Genome-Wide Localization Data Using VAP, a Versatile Aggregate Profiler. In: Leblanc, B., Rodrigue, S. (eds) DNA-Protein Interactions. Methods in Molecular Biology, vol 1334. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2877-4_18
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DOI: https://doi.org/10.1007/978-1-4939-2877-4_18
Publisher Name: Humana Press, New York, NY
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Online ISBN: 978-1-4939-2877-4
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