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Glycobiology of the Nervous System pp 245–262Cite as

Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System

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Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 9))

Abstract

Myelin-associated glycoprotein (MAG) is a 100 kDa glycoprotein located at the innermost layer of myelin sheets that remains in intimate contact with the axonal membrane. It is selectively expressed by myelinating cells including Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). Due to its selective location and its effects on neurons, it was originally thought to be involved in axon–glia communication. The generation of MAG-deficient mice greatly expanded our knowledge about the physiological role of MAG, which helped to establish its critical roles in the normal formation and maintenance of myelinated axons. Interest in MAG was revived when it was described as the first myelin-derived inhibitor of axon regeneration. Since then numerous publications have provided detailed information about its axonal receptors and their signaling pathways. Recently, the nurture role of MAG on neurons was confirmed. On the other hand, MAG mediates signals coming from the axons that strongly impact on oligodendrocytes and Schwann cells, highlighting the bidirectional nature of axon–glia communication. Overall, MAG is a critical component of axon–glia interactions with multiple functions in the biology of both neurons and glial cells.

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Authors and Affiliations

  1. Laboratorio de Neurobiología, Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Córdoba, Argentina

    Pablo H. H. Lopez

  2. Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina

    Pablo H. H. Lopez

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  1. Pablo H. H. Lopez
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Correspondence to Pablo H. H. Lopez .

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  1. Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA

    Robert K. Yu

  2. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA

    Cara-Lynne Schengrund

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The author declares that he has no conflict of interest.

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Lopez, P.H.H. (2014). Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System. In: Yu, R., Schengrund, CL. (eds) Glycobiology of the Nervous System. Advances in Neurobiology, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1154-7_11

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