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Central D1 Dopamine Receptors pp 55–63Cite as

Dopamine D1 and D2 Receptor Selectivities of Agonists and Antagonists

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 235))

Summary

The selectivities of various dopamine agonists and antagonists for dopamine D1 and D2 receptors were obtained by comparing their relative dissociation constants for inhibiting the binding of [3H]SCH 23390 at D1 receptors (calf caudate nucleus) and at D2 receptors (pig anterior pituitary tissue). The most selective agonists were SK&F 38393 (for D1) and (+)-PHNO (for D2), while the most selective antagonists were SCH 23390 (for D1) and raclopride or eticlopride (for D2).

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References

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Authors and Affiliations

  1. Department of Pharmacology Medical Sciences Building, University of Toronto, Toronto, Canada, M5S 1A8

    Philip Seeman & Carla Ulpian

Authors
  1. Philip Seeman
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  2. Carla Ulpian
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Editor information

Editors and Affiliations

  1. New York University Medical Center, New York, New York, USA

    Menek Goldstein

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Fuxe

  3. Schering Corporation, Bloomfield, New Jersey, USA

    Irving Tabachnick

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© 1988 Springer Science+Business Media New York

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Seeman, P., Ulpian, C. (1988). Dopamine D1 and D2 Receptor Selectivities of Agonists and Antagonists. In: Goldstein, M., Fuxe, K., Tabachnick, I. (eds) Central D1 Dopamine Receptors. Advances in Experimental Medicine and Biology, vol 235. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2723-1_5

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  • DOI: https://doi.org/10.1007/978-1-4899-2723-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2725-5

  • Online ISBN: 978-1-4899-2723-1

  • eBook Packages: Springer Book Archive

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