Abstract
Anxiety disorders are a group of mental disorders that range in their severity from occasional, brief episodes of relatively benign nervous tension to severe, recurrent and disabling panic attacks that interfere with activities of daily living. In addition to the suffering of the affected individual, anxiety disorders have larger social and economic ramifications, such as loss of workplace productivity.1 Treatment approaches to anxiety disorders include psychoanalytic, cognitive, and pharmacologic therapies. At present, state of the art Western medical therapies for anxiety rely heavily on anxiolytic (anti-anxiety) pharmaceuticals, some of which have sedative and cognitive side effects. Since the 1960’s, when the prototypic anxiolytic drug diazepam (valium) was discovered serendipitously by L. Sternbach and E. Reeder2, antianxiety drugs have undergone refinement with the goal of reducing undesirable sedative and amnestic side effects. Advances in the fields of neurobiology and psychology have yielded insights into the neurotransmitter systems involved in fear and anxiety responses that have facilitated the development of more selective anxiolytic drugs.3–5
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.P. Lepine, The epidemiology of anxiety disorders: prevalence and societal costs. J Clin Psychiatry, 2002.63(Suppl 14): p. 4–8.
L. Sternbach, et al., Quinazolines and 1,4-benzodiazepines. XXV. Structure-activity relationships of aminoalkyl-subsituted 1,4-benzodiazepin-2-ones. J Med Chem, 1965.8(6): p. 815–821.
P. Sah, et al., The amygdaloid complex: anatomy and physiology. Physiol Rev, 2003.83(3): p. 803–834.
A. Shekhar, L. Sims, and R. Bowsher, GABA receptors in the region of the dorsomedial hypothalamus of rats regulate anxiety in the elevated plus-maze test. II. Physiological measures. Brain Res, 1993.627(1): p. 17–24.
A. Shekhar and J. Katner, Dorsomedial hypothalamic GABA regulates anxiety in the social interaction test. Pharmacol Biochem Behav, 1995.50(2): p. 253–258.
E. Ernst, Safety concerns about kava. Lancet, 2002.359(9320): p. 1865.
M.B. First, Diagnostic and Statistical Manual-Text Revision (DSM-IV-TR TM , 2000). 2000, Washington, D.C.: American Psychiatric Association.
S. Lee, Socio-cultural and global health perspectives for the development of future psychiatric diagnostic systems. Psychopathology. 2002 Mar-Jun; 35(2–3):152–7., 2002. 35((2–3)): p. 152–157.
L. Y, The burden of depression and anxiety in general medicine. J Clin Psychiatry, 2001.62(8): p. 4–9.
J. Chen, L. Reich, and H. Chung, Anxiety disorders. West J Med, 2002.176(4): p. 249–253.
E. De Souza, Neuroendocrine effects of benzodiazepines. J Psychiatr Res, 1990.24(Suppl 2): p. 111–119.
R. Lydiard, The role of GABA in anxiety disorders. J Clin Psychiatry, 2003.64(Suppl 3): p. 21–27.
P. Dodd, Excited to death: different ways to lose your neurones. Biogerontology, 2002. 3(1–2): p. 51–56.
P. Whiting, et al., Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann N YAcad Sci, 1999.868: p. 645–653.
D. Pritchett, H. Luddens, and P. Seeburg, Type I and type II GABAA-benzodiazepine receptors produced in transfected cells. Science. 1989 Sep 22;245(4924):1389–92, 1989.245(4924): p. 1389–1392.
G. Smith and R. Olsen, Functional domains of GABAA receptors. Trends Pharmacol Sci, 1995.16(5): p. 162–168.
R. McKernan and P. Whiting, Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci, 1996.19(4): p. 139–143.
E. Korpi, et al., GABA(A)-receptor subtypes: clinical efficacy and selectivity of benzodiazepine site ligands. Ann Med., 1997.29(4): p. 275–282.
S. Stahl, Selective actions on sleep or anxiety by exploiting GABA-A/benzodiazepine receptor subtypes. J Clin Psychiatry, 2002.63(3): p. 179–180.
J. Atack, Anxioselective Compounds Acting at the GABAA Receptor Benzodiazepine Binding Site. Curr Drug Target CNS Neurol Disord, 2003.2(4): p. 213–232.
G. Griebel, et al., SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors. J Pharmacol Exp Ther, 2001.298(2): p. 753–768.
J. Crawley and F. Goodwin, Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav, 1980.13(2): p. 167–170.
R. Young and D. Johnson, A fully automated light/dark apparatus useful for comparing anxiolytic agents. Pharmacol Biochem Behav, 1991.40(4): p. 739–743.
E. Lepicard, et al., Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice. Pharmacol Biochem Behav, 2000.67(4): p. 739–748.
S. Pellow, et al., Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods, 1985.14(3): p. 149–167.
J. Simiand, P. Keane, and M. Morre, The staircase test in mice: a simple and efficient procedure for primary screening of anxiolytic agents. Psychopharmacology, 1984.84(1): p. 48–53.
L. Steru, et al., Comparing benzodiazepines using the staircase test in mice. Neurosci Biobehav Rev, 1985.9: p. 45–54.
S. File, What can be learned from the effects of benzodiazepines on exploratory behavior? Neurosci Biobehav Rev, 1985.9: p. 45–54.
R. Soulimani, et al., Behavioral effects of passiflora incarnata and its indole alkaloid and flavenoid derivatives and maltol in the mouse. J. Ethnopharmacol, 1997.57: p. 11–20.
S. Akhondzadeh, et al., Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clinical Pharmacy and Therapeutics, 2001.26: p. 369–373.
T. Field, D. Lee, and N. Holbrook, Why leaves turn red in autumn. The role of anthocyanins in senescing leaves of red-osier dogwood. Plant Physiol, 2001. 127: p. 566–574.
B. Winkel-Shirley, Biosynthesis of flavonoids and effects of stress. Curr Opin Plant Biol, 2002.5: p. 218–223.
H. Ha, et al., Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures. Biol Pharm Bull, 2003.26(4): p. 544–546.
a.M.A. Speroni E, Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med, 1988.54: p. 488–491.
C.S. Picq M, Prigent AF, Effect of two flavonoid compounds on central nervous system. Analgesic activity. Life Sci, 1991.49(26): p. 1979–1988.
J. Medina, et al., Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol, 1990.40(10): p. 2227–2231.
E. Nogueira and V. Vassilieff, Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system. J Ethnopharmacol, 2000.70(3): p. 275–280.
A. Paladini, et al., Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol, 1999.51(5): p. 519–526.
M. Marder and A. Paladini, GABA(A)-receptor ligands of flavonoid structure. Curr Top Med Chem, 2002.2(8): p. 853–867.
C. Wolfman, et al., Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav, 1994.47(1): p. 1–4.
J. Medina, et al., Overview-flavonoids: a new family of benzodiazepine receptor ligands. Neurochem Res, 1997.22(4): p. 419–425.
R.F. Petry RD, de-Paris F, Gosmann G, Salgueiro JB, Quevedo J, Kapczinski F, Ortega GG, Schenkel EP, Comparative pharmacological study of hydroethanol extracts of Passiflora alata and Passiflora edulis leaves. Phytother Res, 2001.15(2): p. 162–164.
K. Dhawan, S. Kumar, and A. Sharma, Comparative anxiolytic activity profile of various preparations of Passiflora incarnata linneaus: a comment on medicinal plants’ standardization. J Altern Complement Med, 2002.8(3): p. 283–291.
K. Dhawan, S. Kumar, and A. Sharma, Anxiolytic activity of aerial and underground parts of Passiflora incarnata. Fitoterapia, 2001.72(8): p. 922–926.
D. Loew and M. Kaszkin, Approaching the problem of bioequivalence of herbal medicinal products. Phytotherapy research, 2002.16: p. 705–711.
K. Hui, X. Wang, and H. Xue, Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med.2000 Feb;66(1): 91–3, 2000.
J. Goutman, et al., Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. Eur J Pharmacol, 2003. 461((2–3)): p. 79–87.
K. Hui, et al., Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem Pharmacol, 2002.64(9): p. 1415–1424.
H. Viola, et al., 6-Chloro-3′-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity. Pharmacol Biochem Behav, 2000.65(2): p. 313–320.
M. Huen, et al., 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol, 2003.66(1): p. 125–132.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer Science+Business Media New York
About this paper
Cite this paper
Roberts, A.A. (2004). Testing Efficacy of Natural Anxiolytic Compounds. In: Cooper, E.L., Yamaguchi, N. (eds) Complementary and Alternative Approaches to Biomedicine. Advances in Experimental Medicine and Biology, vol 546. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4820-8_13
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4820-8_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3441-3
Online ISBN: 978-1-4757-4820-8
eBook Packages: Springer Book Archive