Abstract
Although broadly defined in the literature, for the purpose of this section, we define systems biology as the description of the dynamic genomic, proteomic, and metabolomic processes integrated into a functional model of the cell, organelle, or tissue that is capable of accurately tracking the biological system’s response to environmental perturbations. The goal of this section is to complete the tripartite description of asthma systems biology, initiated by the previous section (Section II: Genetics and Genomics of Asthma), by reviewing the recent literature—the types and methods of sample collection, processing, analysis, and instrumentation—of metabolomic and proteomic investigations, including functional proteomic studies of the asthma innate immune response and glucocorticoid (GC) receptor signaling with reference to GC resistance in severe asthma.
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© 2014 Springer Science+Business Media New York
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Wiktorowicz, J.E. (2014). Overview. In: Brasier, A. (eds) Heterogeneity in Asthma. Advances in Experimental Medicine and Biology, vol 795. Humana Press, Boston, MA. https://doi.org/10.1007/978-1-4614-8603-9_12
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DOI: https://doi.org/10.1007/978-1-4614-8603-9_12
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Publisher Name: Humana Press, Boston, MA
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Online ISBN: 978-1-4614-8603-9
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