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Taurine 8 pp 93–103Cite as

Effects of Taurine Supplementation Upon Food Intake and Central Insulin Signaling in Malnourished Mice Fed on a High-Fat Diet

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 776))

Abstract

Feeding behavior is a major determinant of body composition, adiposity, and glucose homeostasis. Both obesity and malnutrition are risk factors for the metabolic syndrome and are associated with altered food intake. Here we assessed the effects of taurine (TAU) supplementation upon adiposity, food intake, and central insulin signaling in malnourished mice fed on a high-fat diet (HFD). Weaned male C57BL/6 mice were fed a control (14% protein-C) or a protein-restricted (6% protein-R) diet. After 6 weeks, both groups received or not HFD for 8 weeks (CH and RH). Half of the HFD groups were supplemented with 5% TAU (CHT and RHT). Both HFD groups were overweight and showed increased perigonadal and retroperitoneal fat pads. TAU supplementation attenuated obesity in CHT but not in RHT mice. HFD induced hypercholesterolemia and glucose intolerance, although only CH group presented fasting hyperglycemia. TAU supplementation also improved glucose homeostasis only in CHT mice. Western blot analysis showed a reduction of 55% in CH hypothalamic content of phosphorylated IRS-1 (pIRS-1) at basal condition compared with C. TAU treatment increased 35% Akt phosphorylation levels in CHT without modification in RHT hypothalamus. However, TAU supplementation did not alter hypothalamic pIRS-1 amount. CH and RH mice presented increased calorie intake that was normalized in CHT but not in RHT. In conclusion, mice fed on an HFD developed obesity, hypercholesterolemia, glucose intolerance, and increased calorie intake. TAU promoted increased hypothalamic insulin action only in CH mice which was linked to prevention of overfeeding, obesity, and glucose intolerance. Protein-restriction promoted metabolic damages that were not prevented by TAU supplementation.

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Abbreviations

TAU:

Taurine

ARC:

Arcuate nuclei

T2DM:

Type 2 diabetes mellitus

CNS:

Central nervous system

ICV:

Intracerebroventricular

TNF:

Tumor necrosis factor

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Acknowledgements

This study was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional para o Desenvolvimento Científico e Tecnológico (CNPq), and Instituto Nacional de Ciência e Tecnologia (INCT).

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Authors and Affiliations

  1. Departamento de Biologia Funcional e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil

    Rafael L. Camargo, Thiago M. Batista, Antônio C. Boschero & Everardo M. Carneiro

  2. Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Macaé, RJ, Brazil

    Rosane A. Ribeiro

  3. Departamento de Clínica Médicas, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil

    Lício A. Velloso

Authors
  1. Rafael L. Camargo
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  2. Thiago M. Batista
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  3. Rosane A. Ribeiro
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  4. Lício A. Velloso
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  5. Antônio C. Boschero
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  6. Everardo M. Carneiro
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Corresponding author

Correspondence to Rafael L. Camargo .

Editor information

Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

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Camargo, R.L., Batista, T.M., Ribeiro, R.A., Velloso, L.A., Boschero, A.C., Carneiro, E.M. (2013). Effects of Taurine Supplementation Upon Food Intake and Central Insulin Signaling in Malnourished Mice Fed on a High-Fat Diet. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 776. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6093-0_10

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