Skip to main content
SpringerLink
Log in

Polymeric Platinol Derivative of Methotrexate for the Treatment of Virally Related Juvenile Diabetes

  • Chapter
Advances in Biomedical Polymers

Abstract

The polyamine derived from tetrachloroplatinate and methotrexate successfully inhibits the growth of the diabetic encephalomyocarditis, EMC-D, virus in male mice and female mice treated with testosterone employing a vaccine like protocol where the Pt-MX polymer is administered prior to infection by the EMC-D virus. Infection by the EMC-D virus is successfully halted if the Pt-MX polymer is administered within one day after viral infection. Thus the Pt-MX polymer is effective at minimizing or eliminating a virus that produces juvenile diabete-like symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. T. H. Maugh, Science, 191, 272 (1976).

    Article  Google Scholar 

  2. P. J. Palumbo, L. R. Elveback, C. -P. Chu, D. C. Connolly and L. T. Kurland, Diabetes, 25, 566 (1976).

    Article  CAS  Google Scholar 

  3. D. L. Rimoin, Calif. Med., 119, 14 (1973).

    CAS  Google Scholar 

  4. B. Blank, “Burger’s Medicinal Chemistry, Part II”, 4th Ed., M. E. Wolff, Ed., Chapter 31, Wiley-Interscience, NY, 1979.

    Google Scholar 

  5. J. E. Craighead and M. F. McLane, Science, 162, 913 (1968).

    Article  CAS  Google Scholar 

  6. D. W. Boucher and A. L. Notkins, J. Exp. Med., 137, 1226 (1973).

    Article  CAS  Google Scholar 

  7. T. H. Maugh, Science, 188, 347 and 436 (1975).

    Article  Google Scholar 

  8. C. E. Hunt, J. R. Lindsey and S. U. Walkley, Fed. Proc., 35, 1206 (1976).

    CAS  Google Scholar 

  9. F. G. Banting and C. H. Best, J. Lab. Clin. Med., 7, 251 (1922).

    CAS  Google Scholar 

  10. J. Craighead, N. Eng. J. Med., 299, 1439 (1978).

    Article  CAS  Google Scholar 

  11. E. Rayfield and Y. Seto, Diabetes, 27, 1126 (1978).

    CAS  Google Scholar 

  12. K. Hayashi, D. Boucher and A. Hotkins, Amer. J. Path., 75, (1974).

    Google Scholar 

  13. H. Whitcomb, V. Merluzzi and S. Copperband, Cell. Immunol., 21, 272 (1976).

    Article  CAS  Google Scholar 

  14. C. L. Gould, M. Trombley, N. Bigley, K. McMannamor and D. J. Giron, Proc. Soc. Exp. Biol. Med., 175, 449 (1984).

    CAS  Google Scholar 

  15. J. Yoon, T. Onodera and A. Notkins, J. Gen. Virol., 37, 225 (1977).

    Article  CAS  Google Scholar 

  16. D. J. Giron, R. Tu, F. Hemphil, F. Pindak and J. Schmidt, Proc. Soc. Exp. Biol. Med., 163, 142 (1980).

    Google Scholar 

  17. U. Ray, G. Aulaakh, M. Schubert, P. McClintock, J. Yoon and A. Notkins, J. Gen. Virol., 64, 947 (1983).

    Article  CAS  Google Scholar 

  18. U. K. Kenkare and B. M. Braganca, Biochem. J., 86, 160 (1963).

    CAS  Google Scholar 

  19. F. M. Heunnekens and M. J. Osborn, Advan. Enzymol., 21, 369 (1959).

    Google Scholar 

  20. J. C. Rabinowitz, “The Enzymes”, 2nd Ed., Vol. 2, Part A, P. D. Boyer, H. Lardy and K. Myrback, Eds., Academic Press, NY, 1960, p. 185.

    Google Scholar 

  21. J. S. O’Brien, Cancer Res., 22, 267 (1962).

    Google Scholar 

  22. M. Friedkin, Ann. Rev. Biochem., 32, 185 (1963).

    Article  CAS  Google Scholar 

  23. J. R. Bertino, J. P. Perkins and D. G. Johns, Biochemistry, 4, 839 (1965).

    Article  CAS  Google Scholar 

  24. W. C. Werkheiser, J. Bio. Chem., 236, 888 (1961).

    CAS  Google Scholar 

  25. W. C. Werkheiser, Cancer Res., 25, 1608 (1965).

    CAS  Google Scholar 

  26. J. R. Bertino, B. A. Booth, A. L. Beiber, A. Cashmore and A. C. Sartorelli, J. Bio. Chem., 239, 479 (1964).

    CAS  Google Scholar 

  27. A. W. Schrecker and F. M. Huennakens, Biochem. Pharmacol., 13, 731 (1964).

    Article  CAS  Google Scholar 

  28. S. F. Zakrzewski, J. Bio. Chem., 238, 1485 (1963).

    CAS  Google Scholar 

  29. S. F. Zakrzewski, J. Bio. Chem., 238, 4002 (1963).

    CAS  Google Scholar 

  30. B. R. Baker, Cancer Chemother. Rep., 4, 1 (1959).

    Google Scholar 

  31. B. R. Baker and J. H. Jordan, J. Pharm. Sci., 54, 1740 (1965).

    Article  CAS  Google Scholar 

  32. R. Roth, J. M. Smith and M. E. Hultquist, J. Amer. Chem. Soc., 72, 1914 (1950).

    Article  CAS  Google Scholar 

  33. R. Roth, J. M. Snith and M. E. Hultquist, J. Amer. Chem. Soc., 73, 2864 (1951).

    Article  CAS  Google Scholar 

  34. C. A. Nichol and A. D. Welch, Proc. Soc. Exp. Bio. Med., 74, 403 (1950).

    CAS  Google Scholar 

  35. H. H. Jukes and H. P. Broquist, “Metabolic Inhibitors”, Vol. 1, R. M. Hochester and J. H. Quastral, Eds., Acadeaic Press, NY, 1963, pp. 481–534.

    Google Scholar 

  36. C. G. Hitchings and J. J. Burchall, “Advances in Enzymology”, Vol. 27, F. F. Nord, Ed., Wiley-Interscience, NY, 1965, pp. 417–468.

    Google Scholar 

  37. T. Y. Shen, “Burger’s Medicinal Chemistry”, 4th Ed., Part III, M. E. Wolff, Ed., Wiley-Interscience, NY, 1981, p. 1254.

    Google Scholar 

  38. H. H. Roenigk, H. J. Mailback and G. D. Weinstein, Arch. Dermatol, 105, 363 (1972).

    Article  Google Scholar 

  39. R. L. Black, W. M. O’Brien, E. J. Van Scott, R. Auerbach, A. Z. Eisen and J. J. Bunim, J. Amer. Med. Assoc., 189, 743 (1964).

    CAS  Google Scholar 

  40. M. C. Berenbaum, Lancet, 2, 1363 (1964).

    Article  CAS  Google Scholar 

  41. B. Rosenberg, L. Van Camp and T. Krigas, Nature, 205, 698 (1965).

    Article  CAS  Google Scholar 

  42. C. Litterest, A. Leroy and A. Guarino, Cancer Treat. Rep., 63, 1485 (1979).

    Google Scholar 

  43. H. Vandenberg, H. Fravaled and J. Roberts, J. Clin. Hem. and Onc., 7, 349 (1977).

    CAS  Google Scholar 

  44. M. Rosenwieg, D. VonHoff and H. Slavik, Ann. Int. Med., 86, 803 (1977).

    Google Scholar 

  45. L. Einhorn and J. Donahue, J. Urol, 117, 65 (1977).

    CAS  Google Scholar 

  46. D. Calvo, Y. Patt and S. Wallace, Cancer, 45, 1278 (1980).

    Article  Google Scholar 

  47. D. VonHoff, R. Schilsky and C. Reichert, Cancer Treat. Rep., 63, 1527 (1979).

    CAS  Google Scholar 

  48. I. Krakoff, Cancer Treat. Rep., 63, 1523 (19790.

    CAS  Google Scholar 

  49. C. Litterest, I. Torres and A. Guarino, J. Clin. Hem. and Onc., 7, 357 (1973).

    Google Scholar 

  50. J. Kovach, C. Moretel and A. Schutt, Cancer Chemother. Rep., 51, 357 (1973).

    Google Scholar 

  51. C. Carraher, D. Giron and W. Scott, “Bioactive Polyaeric Systems”, C. G. Gebelein and C. Carraher, Eds., Plenun Press, NY, 1985, Chapter 20.

    Google Scholar 

  52. C. Cvitkovic, J. Spaulding and V. Bethune, Cancer, 39, 1357 (1977).

    Article  CAS  Google Scholar 

  53. J. Hill, E. Loeb and A. MacLellan, Cancer Chemother. Rep., 59, 647 (1975).

    CAS  Google Scholar 

  54. S. D. Williams and L. H. Einhorn, Adv. Int. Hed., 27, 531 (1982).

    CAS  Google Scholar 

  55. C. E. Merrin, Cancer Treat. Rep., 63, 1579 (1979).

    CAS  Google Scholar 

  56. C. Carraher, W. Scott, D. Giron and J. Schroeder, J. Macromol. Sci., A-l, A15(4), 725 (1981).

    Google Scholar 

  57. C. Carraher, D. Giron, I. Lopez, D. R. Cerutis and W. J. Scott, Organic Coatings and Plastic Chemistry, 44, 120 (1981).

    CAS  Google Scholar 

  58. C. Carraher, W. J. Scott, J. A. Schroeder and D. Giron, J. Macromol. Sco. Chem., A15(4), 625 (1981).

    Article  Google Scholar 

  59. C. Carraher, D. Giron and coworkers, Unpublished results.

    Google Scholar 

  60. D. Giron. M. Espy, C. Carraher, I. Lopez and C. Turner, Polymeric Materials, 51, 312 (1984).

    CAS  Google Scholar 

  61. C. Carraher, T. Manek, D. Giron, H. Trombley, G. Hess, K. Casberg and W. Scott, “New Monomers and Polymers”, Eds. W. Culberson and C. Pittman, Plenum Publ. Co., NY (1984).

    Google Scholar 

  62. C. Carraher, T. Manek, M. Trombley, G. Hess and D. Giron, Polymer Preprints, 24(1), 69 (1983).

    CAS  Google Scholar 

  63. C. Carraher and T. Manek, Polymer Preprints, 23(2), 77 (1982).

    CAS  Google Scholar 

  64. J. Yoon and A. Notkins, Metabolism, 32(7), 37 (1983).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Florida Atlantic University, Boca Raton, Florida, 33431, USA

    Charles E. Carraher Jr.

  2. Department of Chemistry, Wright State University, Dayton, Ohio, 45435, USA

    Charles E. Carraher Jr. & Isabel Lopez

  3. Department of Microbiology and Immunology, Wright State University, Dayton, Ohio, 45435, USA

    David J. Giron

Authors
  1. Charles E. Carraher Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabel Lopez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David J. Giron
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Chemistry, Youngstown State University, Youngstown, Ohio, 44555, USA

    Charles G. Gebelein

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Carraher, C.E., Lopez, I., Giron, D.J. (1987). Polymeric Platinol Derivative of Methotrexate for the Treatment of Virally Related Juvenile Diabetes. In: Gebelein, C.G. (eds) Advances in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1829-3_28

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1829-3_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9022-3

  • Online ISBN: 978-1-4613-1829-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation