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Molecular Signatures of Hepatocellular Carcinoma Metastasis

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Molecular Genetics of Liver Neoplasia

Part of the book series: Cancer Genetics ((CANGENETICS))

Abstract

Metastasis is a significant contributor to morbidity and mortality among cancer patients. Such patients are often considered incurable with treatments offering either supportive care or aggressive management without curative intent. Over the last several decades, research in the metastasis field has expanded our knowledge of cancer progression mechanisms; however, the translation of this knowledge into effective anti-metastasis therapies has not been swift. In fact, to add to the complexity of metastasis, recent findings have challenged the classic notion of clonal evolution whereby liver metastases develop during late stages of carcinogenesis. In this chapter, we evaluate several metastasis models and where applicable, describe how high-throughput molecular profiling technology has shed light on and provided prognostic value for this multifaceted process, with emphasis on the liver. The resolution of metastasis will have a large impact on clinical advances, specifically in targeted anti-metastasis therapies to benefit patients.

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Authors and Affiliations

  1. Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-4255, USA

    Anuradha Budhu

  2. Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, 37 Convent Drive, MSC 4258, Building 37, Room 3044A, Bethesda, MD, 20892, USA

    Xin Wei Wang Ph.D (Senior Investigator, Head)

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  1. Anuradha Budhu
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  2. Xin Wei Wang Ph.D
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Correspondence to Anuradha Budhu .

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Editors and Affiliations

  1. Lab. Human Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Xin Wei Wang

  2. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Joe W. Grisham

  3. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Snorri S. Thorgeirsson

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Budhu, A., Wang, X.W. (2010). Molecular Signatures of Hepatocellular Carcinoma Metastasis. In: Wang, X., Grisham, J., Thorgeirsson, S. (eds) Molecular Genetics of Liver Neoplasia. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6082-5_13

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