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The Forkhead Transcription Factors Play Important Roles in Vascular Pathology and Immunology

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Forkhead Transcription Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 665))

Abstract

Transcription factor families are a small number of upstream master genes in “higher hierarchy” that control the expression of a large number of downstream genes. These transcription factors have been found to integrate the signaling pathways underlying the pathogenesis of cardiovascular diseases with or without autoimmune inflammatory mechanisms. In this chapter, we organize our analysis of recent progress in characterization of forkhead (FOX) transcription factor family members in vascular pathology and immune regulation into the following sections: (1) Introduction of the FOX transcription factor superfamily; (2) FOX transcription factors and endothelial cell pathology; (3) FOX transcription factors and vascular smooth muscle cells; and (4) FOX transcription factors, inflammation and immune system. Advances in these areas suggest that the FOX transcription factor family is important in regulating vascular development and the pathogenesis of autoimmune inflammatory cardiovascular diseases.

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Authors and Affiliations

  1. Department of Pharmacology Cardiovascular Research Center, Temple University School of Medicine, 3420 North Broad Street, MRB, Rm 325, Philadelphia, Pennsylvania, 19140, USA

    Xiao-Feng Yang, Pu Fang, Shu Meng, Michael Jan, Xinyu Xiong, Ying Yin & Hong Wang

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  1. Xiao-Feng Yang
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  2. Pu Fang
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  3. Shu Meng
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  4. Michael Jan
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  5. Xinyu Xiong
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  6. Ying Yin
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  7. Hong Wang
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Correspondence to Xiao-Feng Yang .

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Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  4. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  5. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  6. Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

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© 2009 Landes Bioscience and Springer+Business Media

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Yang, XF. et al. (2009). The Forkhead Transcription Factors Play Important Roles in Vascular Pathology and Immunology. In: Maiese, K. (eds) Forkhead Transcription Factors. Advances in Experimental Medicine and Biology, vol 665. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1599-3_7

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