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Mitochondrial Medicine pp 343–356Cite as

Omega-3-PUFA, Omega-6-PUFA and Mitochondria

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Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) belong to the essential fatty acids because the body cannot synthesize them and they must be obtained from the diet. That is why the role of the diet in prevention of mitochondrial damage and pathogenesis of hypertension, coronary artery disease, type 2 diabetes and atherosclerosis has been intensively studied during the last decades. Beneficial effects of n-3-PUFA are probably mediated by their antiarrhythmic, lipid lowering, antithrombotic and anti-inflammatory properties. Long-term supplementation of diabetic patients with n-3-PUFA could positively influence the mitochondrial energy metabolism of their brain, myocardium and pancreas and preserve theses organs from some later complications of diabetes mellitus. Essential n-6-PUFA is only linoleic acid, which is metabolized to arachidonic acid.

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Author information

Authors and Affiliations

  1. Preventive and Sport's Medicine Center, PJ Šafárik University, Košice, Slovakia

    Daniel Pella M.D., Ph.D.

  2. Pharmacobiochemical Laboratory, Comenius University, Bratislava, Slovakia

    Jarmila Kucharská Ph.D.

  3. Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan

    Kuniaki Otsuka M.D.

  4. Halberg Hospital and Research Institute, Moradabad, UP, India

    Ram B. Singh M.D.

Authors
  1. Associate professor Anna Gvozdjáková Ph.D., D.Sc.
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  2. Daniel Pella M.D., Ph.D.
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  3. Jarmila Kucharská Ph.D.
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  4. Kuniaki Otsuka M.D.
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  5. Ram B. Singh M.D.
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Editors and Affiliations

  1. Comenius University, Bratislava, Slovakia

    Anna Gvozdjáková Ph.D., D.Sc.

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Gvozdjáková, A., Pella, D., Kucharská, J., Otsuka, K., Singh, R.B. (2008). Omega-3-PUFA, Omega-6-PUFA and Mitochondria. In: Gvozdjáková, A. (eds) Mitochondrial Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6714-3_19

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  • DOI: https://doi.org/10.1007/978-1-4020-6714-3_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-6713-6

  • Online ISBN: 978-1-4020-6714-3

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