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Gelsolin and Diseases

  • Chapter
Calcium Signalling and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 45))

Abstract

Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Mutant mice for gelsolin as well as clinical studies have shown that gelsolin is linked to a number of pathological conditions such as inflammation, cancer and amyloidosis. The tight regulation of gelsolin by calcium is crucial for its physiological role and constitutive activation leads to apoptosis. In the following we will give an overview on how gelsolin is regulated by calcium, and which clinical conditions have been linked to lack or misregulation of gelsolin

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Authors and Affiliations

  1. Direzione Scientifica, IRCCS Fondazione Ospedale Policlinico, Mangiagalli e Regina Elena, ViaFrancesco Sforza 28, 20122 Milano, Italy

    L. SPINARDI

  2. EMBL Monterotondo, Via Ramarini 32, 00015 Monterotondo, Rome, Italy

    W. WITKE

Authors
  1. L. SPINARDI
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  2. W. WITKE
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Editor information

Editors and Affiliations

  1. University of Padova, Padova, Italy

    Ernesto Carafoli

  2. University of Padova, Padova, Italy

    Marisa Brini

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© 2007 Springer

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SPINARDI, L., WITKE, W. (2007). Gelsolin and Diseases. In: Carafoli, E., Brini, M. (eds) Calcium Signalling and Disease. Subcellular Biochemistry, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6191-2_3

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