Abstract
The present study tests the sex-dependent effect of perinatal taurine exposure on arterial pressure control in adults. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion,TD), 3% taurine (taurine supplementation,TS) or water alone (C) from conception to weaning. Their male and female offspring were then fed normal rat chow and tap water with 5% glucose (C with glucose, CG; TD with glucose, TDG; TS with glucose, TSG) or water alone (CW, TDW or TSW). At 7–8 weeks of age, they were studied in a conscious condition. Body weights were lower in male and female TDG and male TDW rats. Kidney to body weights increased in female TSW but not TSG. Plasma sodium and potassium were not significantly different among males. Among females, plasma sodium levels were lower in all glucose treated groups while plasma potassium levels were lower only in TDG. Hematocrit, fasting blood glucose, and glucose tolerance were not significantly different between the sexes. Mean arterial pressure increased in male TDG, TSW, and TSG while in the females, mean arterial pressure increased in TDW, TDG, and TSG. Heart rates were not significantly different between the sexes. The present data indicate that perinatal taurine exposure alters arterial pressure control of adult rats and this effect is gender specific.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. J Perinat Med 30:281–286
Anuradha CV, Balakrishnan SD (1999) Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Can J Physiol Pharmacol 77:749–754
Ashraf MS, Vongpatanasin W (2006) Estrogen and hypertension. Curr Hypertens Rep 8:368–376
Azuma M, Takahashi K, Fukuda T, Ohyabu Y, Yamamoto I, Kim S, Iwao H, Schaffer SW, Azuma J (2000) Taurine attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac myocytes. Eur J Pharmacol 403:181–188
Barker DJ(2007) The origins of the developmental origins theory. J Intern Med 261:412–417
Barker DJ, Eriksson JG, Forsen T, Osmond C (2002) Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 31:1235–1239
Barraclough CA (1961). Production of anovulatory, sterile rats by single injections of testosterone propionate. Endocrinology 68:62–67
Cella SG, Locatelli V, Mennini T, Zanini A, Bendotti C, Forloni GL, Fumagalli G, Arce VM, de GC, V, Wehrenberg WB, et al. (1990) Deprivation of growth hormone-releasing hormone early in the rat’s neonatal life permanently affects somatotropic function. Endocrinology 127: 1625–1634
Cherif H, Reusens B, Ahn MT, Hoet JJ, Remacle C (1998) Effects of taurine on the insulin secretion of rat fetal islets from dams fed a low-protein diet. J Endocrinol 159:341–348
Clark JT, Chakraborty-Chatterjee M, Hamblin M, Wyss JM, Fentie IH (2004) Estrogen depletion differentially affects blood pressure depending on age in Long-Evans rats. Endocrine 25: 173–186
D’Amore S, Mora S (2006) Gender-specific prediction of cardiac disease: importance of risk factors and exercise variables. Cardiol Rev 14:281–285
Dumesic DA, Abbott DH, Padmanabhan V (2007) Polycystic ovary syndrome and its developmental origins. Rev Endocr Metab Disord 8:127–141
Eriksson JG, Forsen TJ, Kajantie E, Osmond C, Barker DJ (2007) Childhood growth and hypertension in later life. Hypertension 49:1415–1421
Forrester T (2004) Historic and early life origins of hypertension in Africans. J Nutr 134:211–216
Gentile S, Bologna E, Terracina D, Angelico M (1994) Taurine-induced diuresis and natriuresis in cirrhotic patients with ascites. Life Sci 54:1585–1593
Harada H, Tsujino T, Watari Y, Nonaka H, Emoto N, Yokoyama M (2004) Oral taurine supplementation prevents fructose-induced hypertension in rats. Heart Vessels 19:132–136
Harding JE (2001) The nutritional basis of the fetal origins of adult disease. Int J Epidemiol 30: 15–23
Hoet JJ, Ozanne S, Reusens B (2000) Influences of pre- and postnatal nutritional exposures on vascular/endocrine systems in animals. Environ Health Perspect 108 Suppl 3:563–568
Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sanchez-Lozada LG (2007) Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86:899–906
King AJ, Olivier NB, Mohankumar PS, Lee JS, Padmanabhan V, Fink GD (2007). Hypertension caused by prenatal testosterone excess in female sheep. Am J Physiol Endocrinol Metab 292:E1837–E1841
Lackland DT, Egan BM, Syddall HE, Barker DJ (2002) Associations between birth weight and antihypertensive medication in black and white medicaid recipients. Hypertension 39:179–183
Langley-Evans SC (2006) Developmental programming of health and disease. Proc Nutr Soc 65:97–105
Langley-Evans SC, Langley-Evans AJ, Marchand MC (2003) Nutritional programming of blood pressure and renal morphology. Arch Physiol Biochem 111:8–16
Lerdweerapol W, Jirakulsomchok D, Wyss JM, Roysommuti S (2007) Perinatal taurine supplementation influences renal hemodynamics and excretory function in adult, female rats. FASEB J 21 (5 Part I):A501–502
Maturana MA, Irigoyen MC, Spritzer PM (2007) Menopause, estrogens, and endothelial dysfunction: current concepts. Clinics 62:77–86
Mendez MA, Wynter S, Wilks R, Forrester T (2004) Under- and overreporting of energy is related to obesity, lifestyle factors and food group intakes in Jamaican adults. Public Health Nutr 7: 9–19
Meyer MR, Haas E, Barton M (2006) Gender differences of cardiovascular disease: new perspectives for estrogen receptor signaling. Hypertension 47:1019–1026
Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23:381–393
Nandhini AT, Anuradha CV (2004) Hoe 140 abolishes the blood pressure lowering effect of taurine in high fructose-fed rats. Amino Acids 26:299–303
Nandhini AT, Thirunavukkarasu V, Anuradha CV (2004) Potential role of kinins in the effects of taurine in high-fructose-fed rats. Can J Physiol Pharmacol 82:1–8
Ojeda NB, Grigore D, Robertson EB, Alexander BT (2007) Estrogen protects against increased blood pressure in postpubertal female growth restricted offspring. Hypertension 50:679–685
Pacioretty L, Hickman MA, Morris JG, Rogers QR (2001) Kinetics of taurine depletion and repletion in plasma, serum, whole blood and skeletal muscle in cats. Amino Acids 21:417–427
Peng N, Clark JT, Wei CC, Wyss JM (2003) Estrogen depletion increases blood pressure and hypothalamic norepinephrine in middle-aged spontaneously hypertensive rats. Hypertension 41:1164–1167
Racasan S, Braam B, van der Giezen DM, Goldschmeding R, Boer P, Koomans HA, Joles JA (2004) Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats. Hypertension 44:83–88
Roysommuti S, Khongnakha T, Jirakulsomchok D, Wyss JM (2002) Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance. Am J Hypertens 15:773–779
Roysommuti S, Malila P, Jirakulsomchok D, Jirakulsomchok S, Wyss JM (2004) Perinatal taurine status influences renal hemodynamics in adult conscious rats. FASEB J 18 (4 Part I): A292–A293
Roysommuti S, Suvanich A, Jirakulsomchok D, Wyss JM (2007) Perinatal taurine depletion causes autonomic dysregulation in rats on a high glucose diet. FASEB J 21 (6 Part II):A887
Schaffer SW, Lombardini JB, Azuma J (2000) Interaction between the actions of taurine and angiotensin II. Amino Acids 18:305–318
Suvanich A, Jirakulsomchok D, Muchimapura S, Wyss JM, Roysommuti S (2006) Perinatal taurine depletion impairs autonomic control in conscious rats. FASEB J 20 (5 Part II):A1406–A1407
Ventura SJ, Martin JA, Curtin SC, Mathews TJ, Park MM, Hyattsville, MD (eds) (2002) Department of Health and Human Services. National Vital Statistics Report, pp 1–100
Wyss JM, Carlson SH (2003) Effects of hormone replacement therapy on the sympathetic nervous system and blood pressure. Curr Hypertens Rep 5:241–246
Wyss JM, Roysommuti S, King K, Kadisha I, Regan CP, Berecek KH (1994) Salt-induced hypertension in normotensive spontaneously hypertensive rats. Hypertension 23:791–796
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this paper
Cite this paper
Roysommuti, S., Suwanich, A., Lerdweeraphon, W., Thaeomor, A., Jirakulsomchok, D., Wyss, J.M. (2009). Sex Dependent Effects of Perinatal Taurine Exposure on the Arterial Pressure Control in Adult Offspring. In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_14
Download citation
DOI: https://doi.org/10.1007/978-0-387-75681-3_14
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-75680-6
Online ISBN: 978-0-387-75681-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)