Growth factors and their receptors are upregulated during retinal degeneration as an intrinsic tissue response that may protect remaining photoreceptors (Harada et al., 2002;Wen et al., 1995;Yu et al., 2004).Growth factor delivery to animal models of retinal degeneration leads to various degrees of preservation of photoreceptor morphology and function (Chaum, 2003). A major class of neuroprotective growth factors in the retina are the neurotrophinsNGF, BDNF, NT3 and NT4/5. Therapeutic use of these molecules is complicated by their ability to activate pro-death as well as pro-survival pathways.
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References
Arevalo J. C., Waite J., Rajagopal R., Beyna M., Chen Z. Y., Lee F. S. and Chao M. V., 2006, Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50, 549–59.
Chaum E., 2003, Retinal neuroprotection by growth factors: a mechanistic perspective. J Cell Biochem 88, 57–75.
Chen W. G., West A. E., Tao X., Corfas G., Szentirmay M. N., Sawadogo M., Vinson C. and Greenberg M. E., 2003, Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. J Neurosci 23, 2572–81.
Cheng L., Sapieha P., Kittlerova P., Hauswirth W. W. and Di Polo A., 2002, TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci 22, 3977–86.
Fryer H. J., Wolf D. H., Knox R. J., Strittmatter S. M., Pennica D., O’Leary R. M., Russell D. S. and Kalb R. G., 2000, Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway. J Neurochem 74, 582–95.
Harada T., Harada C., Kohsaka S., Wada E., Yoshida K., Ohno S., Mamada H., Tanaka K., Parada L. F. and Wada K., 2002, Microglia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci 22, 9228–36.
Harada T., Harada C., Nakayama N., Okuyama S., Yoshida K., Kohsaka S., Matsuda H. and Wada K., 2000, Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron 26, 533–41.
Kalb R., 2005, The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci 28, 5–11.
Kim H. J., Hwang J. J., Behrens M. M., Snider B. J., Choi D. W. and Koh J. Y., 2003, TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture. Neurobiol Dis 14, 110–9.
Lenzi L., Coassin M., Lambiase A., Bonini S., Amendola T. and Aloe L., 2005, Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa. Vision Res 45, 1491–500.
Meyer-Franke A., Wilkinson G. A., Kruttgen A., Hu M., Munro E., Hanson M. G., Jr., Reichardt L. F. and Barres B. A., 1998, Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 21, 681–93.
Muragaki Y., Chou T. T., Kaplan D. R., Trojanowski J. Q. and Lee V. M., 1997, Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors. J Neurosci 17, 530–42.
Nag T. C. and Wadhwa S., 1999, Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina. Brain Res Dev Brain Res 117, 179–89.
Nakamura K., Harada C., Okumura A., Namekata K., Mitamura Y., Yoshida K., Ohno S., Yoshida H. and Harada T., 2005, Effect of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse. Mol Vis 11, 1229–35.
Patapoutian A., Backus C., Kispert A. and Reichardt L. F., 1999, Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors. Science 283, 1180–83.
Rohrer B., Matthes M. T., LaVail M. M. and Reichardt L. F., 2003, Lack of p75 receptor does not protect photoreceptors from light-induced cell death. Exp Eye Res 76, 125–9.
Roux P. P., Bhakar A. L., Kennedy T. E. and Barker P. A., 2001, The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. J Biol Chem 276, 23097–104.
Taylor S., Srinivasan B., Wordinger R. J. and Roque R. S., 2003, Glutamate stimulates neurotrophin expression in cultured Muller cells. Brain Res Mol Brain Res 111, 189–97.
Timmusk T., Palm K., Metsis M., Reintam T., Paalme V., Saarma M. and Persson H., 1993, Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10, 475–89.
Tuli R., Tuli S., Nandi S., Huang X., Manner P. A., Hozack W. J., Danielson K. G., Hall D. J. and Tuan R. S., 2003, Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J Biol Chem 278, 41227–36.
von Schack D., Casademunt E., Schweigreiter R., Meyer M., Bibel M. and Dechant G., 2001, Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci 4, 977–8.
Wahlin K. J., Adler R., Zack D. J. and Campochiaro P. A., 2001, Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73, 693–701.
Wahlin K. J., Campochiaro P. A., Zack D. J. and Adler R., 2000, Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci 41, 927–36.
Wen R., Song Y., Cheng T., Matthes M. T., Yasumura D., LaVail M. M. and Steinberg R. H., 1995, Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J Neurosci 15, 7377–85.
Wu H., Friedman W. J. and Dreyfus C. F., 2004, Differential regulation of neurotrophin expression in basal forebrain astrocytes by neuronal signals. J Neurosci Res 76, 76–85.
Yu D. Y., Cringle S., Valter K., Walsh N., Lee D. and Stone J., 2004, Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Invest Ophthalmol Vis Sci 45, 2013–19.
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Hackam, A.S. (2008). Regulation of Neurotrophin Expression and Activity in the Retina. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Recent Advances in Retinal Degeneration. Advances in Experimental Medicine and Biology, vol 613. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74904-4_40
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