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Hot Topics in Infection and Immunity in Children IV pp 29–42Cite as

Pathogenesis of Group A Streptococcal Infections and Their Sequelae

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 609))

Streptococcus pyogenesor group A streptococci are Gram positive extracellular bacterial pathogens which colonize the throat or skin and are responsible for a number of suppurative infections and non-suppurative sequelae (Cunningham 2000). As pathogens they evade host defense mechanisms and exhibit a group of virulence determinants. Group A streptococci are a common cause of bacterial pharyngitis, scarlet fever or impetigo. The concept of distinct throat and skin strains arose from decades of epidemiological studies, where it became evident that there were serotypes of group A streptococci with a strong tendency to cause throat infection, and similarly, there were other serotypes often associated with skin infections (Bisno 1995b). The group A streptococcus is most well recognized for streptococcal toxic shock syndrome and necrotizing fasciitis which involves destruction of the skin and soft tissues in severe cases (Stevens 2000).

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  1. George Lynn Cross Research Professor, Microbiology and Immunology, University of Oklahoma Health Sciences Center, Biomedical Research Center, 975 NE 10th Street, Oklahoma City, OK, 73104

    Madeleine W. Cunningham

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  1. Institute of Child Life and Health UBHT Education Centre, University of Bristol, Upper Maudlin Street, Bristol, BS2 8AE, UK

    Adam Finn

  2. Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Andrew J. Pollard

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Cunningham, M.W. (2008). Pathogenesis of Group A Streptococcal Infections and Their Sequelae. In: Finn, A., Pollard, A.J. (eds) Hot Topics in Infection and Immunity in Children IV. Advances in Experimental Medicine and Biology, vol 609. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73960-1_3

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