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Human Health Effects of Methylmercury Exposure

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References

  • Acha D, Iniguez V, Roulet M, Guimarães, JRDLuna R, Alanoca L, Sanchez S (2005) Sulfate-reducing bacteria in floating macrophyte rhizospheres from an Amazonian floodplain lake in Bolivia and their association with Hg methylation. Appl Environ Microbiol 71:7531–7535.

    CAS  Google Scholar 

  • Adimado AA, Baah DA (2002) Mercury in human blood, urine, hair, and fish from the Ankobra and Tano River Basins in southwestern Ghana. Bull Environ Contam Toxicol 68:339–346.

    CAS  Google Scholar 

  • Agusa T, Kunito T, Iwata H, Monirith I, Tana TS, Subramanian A, Tanabe S (2005) Mercury contamination in human hair and fish from Cambodia: Levels, specific accumulation and risk assessment. Environ Pollut 134:79–86.

    CAS  Google Scholar 

  • Akagi H, Malm O, Branches FJP, Kinjo Y, Kashima Y, Guimaraes JRD, Oliveira RB, Haraguchi K, Pfeiffer WC, Takizawa Y, Kato H (1995) Human exposure to mercury due to goldmining in the Tapajos River Basin, Amazon, Brazil – Speciation of mercury in human hair, blood and urine. Water Air Soil Pollut 80:85–94.

    CAS  Google Scholar 

  • Akagi H, Grandjean P, Takizawa Y, Weihe P (1998) Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. Environ Res 77:98–103.

    CAS  Google Scholar 

  • Al-Majed NB, Preston MR (2000) Factors influencing the total mercury and methyl mercury in the hair of the fishermen of Kuwait. Environ Pollut 109:239–250.

    CAS  Google Scholar 

  • ATSDR (1999) Toxicological Profile for Mercury. Agency for Toxic Substances and Disease Registry, Atlanta, GA.

    Google Scholar 

  • Bakir F, Damluji SF, Amin-Zaki L, Murtadha M, Khalidi A, al-Rawi NY, Tikriti S, Tikriti S, Dahahir HI, Clarkson TW, Smith JC, Doherty RA (1973) Methylmercury poisoning in Iraq. Science 181:230–241.

    CAS  Google Scholar 

  • Ballatori N, Clarkson TW (1982) Developmental-changes in the biliary-excretion of methylmercury and glutathione. Science 216:61–63.

    CAS  Google Scholar 

  • Barbosa AC, Jardim W, Dorea JG, Fosberg B, Souza J (2001) Hair mercury speciation as a function of gender, age, and body mass index in inhabitants of the Negro River Basin, Amazon, Brazil. Arch Environ Contam Toxicol 40:439–444.

    CAS  Google Scholar 

  • Batista J, Schuhmacher M, Domingo JL, Corbella J (1996) Mercury in hair for a child population from Tarragona Province, Spain. Sci Total Environ 193:143–148.

    CAS  Google Scholar 

  • Becker K, Kaus S, Krause C, Lepom P, Schulz C, Seiwert M, Seifert B (2002) German environmental survey 1998 (GerES III): Environmental pollutants in blood of the German population. Int J Hyg Environ Health 205:297–308.

    Google Scholar 

  • Becker K, Schulz C, Kaus S, Seiwert M, Seifert B (2003) German environmental survey 1998 (GerES III): Environmental pollutants in the urine of the German population. Int J Hyg Environ Health 206:15–24.

    CAS  Google Scholar 

  • Berg T, Sekkesaeter S, Steinnes E, Valdal AK, Wibetoe G. (2003)Springtime depletion of mercury in the European Arctic as observed at Svalbard Sci Total Environ 304:43–51.

    CAS  Google Scholar 

  • Bergan T, Rodhe H (2001) Oxidation of elemental mercury in the atmosphere; Constraints imposed by global scale modelling. J Atmos Chem 40:191–212.

    CAS  Google Scholar 

  • Bergan T, Gallardo L, Rodhe H (1999) Mercury in the global troposphere: A three-dimensional model study. Atmos Environ 33: 1575–1585.

    CAS  Google Scholar 

  • Bernard S, Redwood L, Blaxill M (2004) Thimerosal, mercury, and autism: Case study in the failure of the risk assessment paradigm. Neurotoxicol 25:710–710.

    Google Scholar 

  • Bjornberg KA, Vahter M, Petersson-Grawe K, Glynn A, Cnattingius S, Darnerud PO, Atuma S, Aune M, Becker W, Berglund M (2003) Methyl mercury and inorganic mercury in Swedish pregnant women and in cord blood: Influence of fish consumption. Environ Health Perspect 111:637–641.

    Google Scholar 

  • Bouzan C, Cohen JT, Connor WE, Kris-Etherton PM, Gray GM, Konig A, Lawrence RS, Savitz DA, Teutsch SM (2005) A quantitative analysis of fish consumption and stroke risk. Am J Prev Med 29:347–352.

    Google Scholar 

  • Budtz-Jørgensen E, Grandjean P, Jorgensen PJ, Weihe P, Keiding N (2004) Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages. Environ Res 95:385–393.

    Google Scholar 

  • Budtz-Jørgensen E, Grandjean P, Weihe P (2007) Separation of risks and benefits of seafood intake. Environ Health Perspect 115:323–327.

    Google Scholar 

  • Calasans CF, Malm O (1997) Elemental mercury contamination survey in a chlor-alkali plant by the use of transplanted Spanish moss, Tillandsia usneoides (L.). Sci Total Environ 208:165–177.

    CAS  Google Scholar 

  • Campbell LM, Dixon DG, Hecky RE (2003) A review of mercury in Lake Victoria, East Africa: Implications for human and ecosystem health. J Toxicol Environ Health-Part B-Crit Rev 6:325–356.

    CAS  Google Scholar 

  • Canuel R, de Grosbois SB, Atikesse L, Lucotte M, Arp P, Ritchie C, Mergler D, Chan HM, Amyot M, Anderson R (2006) New evidence on variations of human body burden of methylmercury from fish consumption. Environ Health Perspect 114:302–306.

    CAS  Google Scholar 

  • Cernichiari E, Brewer R, Myers GJ, Marsh DO, Lapham LW, Cox C, Shamlaye CF, Berlin M, Davidson PW, Clarkson TW (1995a) Monitoring methylmercury during pregnancy: Maternal hair predicts fetal brain exposure. Neurotoxicol 16:705–709.

    CAS  Google Scholar 

  • Cernichiari E, Toribara TY, Liang L, Marsh DO, Berlin MW, Myers GJ, Cox C, Shamlaye CF, Choisy O, Davidson PW, Clarkson TW (1995b) The biological monitoring of mercury in the Seychelles study. Neurotoxicol 16:613–627.

    CAS  Google Scholar 

  • Clarkson TW (1993) Mercury—Major issues in environmental-health. Environ Health Perspect 100:31–38.

    CAS  Google Scholar 

  • Clarkson TW, Magos L (2006) The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36:609–662.

    CAS  Google Scholar 

  • Clarkson TW, Strain JJ (2003) Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations. J Nutr 133:1539S–1543S.

    CAS  Google Scholar 

  • Clarkson TW, Magos L, Myers GJ (2003) Human exposure to mercury: The three modern dilemmas. J Trace Elem Exp Med 16:321–343.

    CAS  Google Scholar 

  • Crump KS, Kjellstrom T, Shipp AM, Silvers A, Stewart A (1998) Influence of prenatal mercury exposure upon scholastic and psychological test performance: Benchmark analysis of a New Zealand cohort. Risk Analysis 18:701–713.

    CAS  Google Scholar 

  • Choi BH (1989) The effects of methylmercury on the developing brain progress. Neurobiol 32:447–470.

    CAS  Google Scholar 

  • Choi MH, Cech JJ (1998) Unexpectedly high mercury level in pelleted commercial fish feed. Environ Toxicol Chem 17:1979–1981.

    CAS  Google Scholar 

  • Cohen JT, Bellinger DC, Connor WE, Kris-Etherton PM, Lawrence RS, Savitz DA, Shaywitz BA, Teutsch SM, Gray GM (2005a) A quantitative risk-benefit analysis of changes in population fish consumption. Am J Prev Med 29:325–334.

    Google Scholar 

  • Cohen JT, Bellinger DC, Connor WE, Shaywitz BA (2005b) A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development. Am J Prev Med 29:366–374.

    Google Scholar 

  • Cohen JT, Bellinger DC, Shaywitz BA (2005c) A quantitative analysis of prenatal methyl mercury exposure and cognitive development. Am J Prev Med 29:353–365.

    Google Scholar 

  • Cordier S, Garel M, Mandereau L, Morcel H, Doineau P, Gosme-Seguret S, Josse D, White R, Amiel-Tison C (2002) Neurodevelopmental investigations among methylmercury-exposed children in French Guiana. Environ Res 89:1–11.

    CAS  Google Scholar 

  • Dakeishi N, Nakai K, Sakamoto M, Iwata T, Suzuki K, Liu X-J, Ohno T, Kurosawa T, Satoh H, Murata K (2005) Effects of hair treatment on hair mercury—The best biomarker of methylmercury exposure? Environ Health Prev Med 10:208–212.

    CAS  Google Scholar 

  • Daniels JL, Longnecker MP, Rowland AS, Golding J (2004) Fish intake during pregnancy and early cognitive development of offspring. Epidemiol 15:394–402.

    Google Scholar 

  • Campos MS, de Sarkis JES, Muller RCS, Brabo ED, Santos ED (2002) Correlation between mercury and selenium concentrations in Indian hair from Rondonia State, Amazon region, Brazil. Sci Total Environ 287:155–161.

    Google Scholar 

  • Dellinger JA (2004) Exposure assessment and initial intervention regarding fish consumption of tribal members of the Upper Great Lakes Region in the United States. Environ Res 95:325–340.

    CAS  Google Scholar 

  • Dickman MD, Leung CKM, Leong MKH (1998) Hong Kong male subfertility links to mercury in human hair and fish. Sci Total Environ 214:165–174.

    CAS  Google Scholar 

  • Díez S, Bayona JM (2002) Determination of methylmercury in human hair by ethylation followed by headspace solid-phase microextraction-gas chromatography-cold-vapour atomic fluorescence spectrometry. J Chromatogr A 963:345–351.

    Google Scholar 

  • Díez S, Montuori P, Querol X, Bayona JM (2007) Total mercury in the hair of children by combustion atomic absorption spectrometry (Comb-AAS). J Anal Toxicol 31:144–149.

    Google Scholar 

  • Díez S, Montuori P, Pagano A, Sarnacchiaro P, Bayona JM, Triassi M (2008a) Hair mercury levels in an urban population from southern Italy: Fish consumption as a determinant of exposure. Environ Int 34:162–167.

    Google Scholar 

  • Díez S, Delgado S, Aguilera I, Astray J, Pérez-Gómez B, Torrent M, Sunyer J, Bayona JM (2008b) Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country. Arch Environ Contam Toxicol. In press. doi:10.1007/s00244-008-9213-7

    Google Scholar 

  • Dolbec J, Mergler D, Passos CJS, de Morais SS, Lebel J (2000) Methylmercury exposure affects motor performance of a riverine population of the Tapajos river. Braz Amazon Int Arch Occupat Environ Health 73:195–203.

    CAS  Google Scholar 

  • Dolbec J, Mergler D, Larribe F, Roulet M, Lebel J, Lucotte M (2001) Sequential analysis of hair mercury levels in relation to fish diet of an Amazonian population, Brazil. Sci Total Environ 271:87–97.

    CAS  Google Scholar 

  • Dorea JG (2006) Fish meal in animal feed and human exposure to persistent bioaccumulative and toxic substances. J Food Prot 69:2777–2785.

    CAS  Google Scholar 

  • Dorea JG, Barbosa , ACFerrari I, De Souza JR (2003) Mercury in hair and in fish consumed by Riparian women of the Rio Negro, Amazon, Brazil. Int J Environ Health Res 13:239–248.

    CAS  Google Scholar 

  • Dorea JG, de Souza JR, Rodrigues P, Ferrari I, Barbosa AC (2005) Hair mercury (signature of fish consumption) and cardiovascular risk in Munduruku and Kayabi Indians of Amazonia. Environ Res 97:209–219.

    CAS  Google Scholar 

  • Drasch G, Bose-O’Reilly S, Beinhoff C, Roider G, Maydl S (2001) The Mt Diwata study on the Philippines 1999: Assessing mercury intoxication of the population by small scale gold mining. Sci Total Environ 267:151–168.

    CAS  Google Scholar 

  • Duford DA, Lafleur JP, Lam R, Skinner CD, Salin ED (2007) Induction heating-electrothermal vaporization for direct mercury determination in a single human hair by atomic fluorescence and atomic absorption spectrometry. J Anal At Spectrom 22:326–329.

    CAS  Google Scholar 

  • Easton MDL, LuszniakD, Von der Geest E (2002) Preliminary examination of contaminant loadings in farmed salmon, wild salmon and commercial salmon feed. Chemosphere 46:1053–1074.

    CAS  Google Scholar 

  • Ebinghaus R, Kock HH, Temme C, Einax JW, Lowe AG, Richter A, Burrows JP, Schroeder WH (2002) Antarctic springtime depletion of atmospheric mercury. Environ Sci Technol 36:1238–1244.

    CAS  Google Scholar 

  • Elhamri H, Idrissi L, Coquery M, Azemard S, El Abidi A, Benlemlih M, Saghi M, Cubadda F (2007) Hair mercury levels in relation to fish consumption in a community of the Moroccan Mediterranean coast. Food Addit Contam 24:1236–1246.

    CAS  Google Scholar 

  • FDA (U.S. Food and Drug Administration) (1990–2004) Mercury levels in commercial fish and shellfish, at [http://www.cfsan.fda.gov/~frf/sea-mehg.html].

  • Feng QY, Suzuki Y, Hisashige A (1998) Hair mercury levels of residents in China, Indonesia, and Japan. Arch Environ Health 53:36–43.

    CAS  Google Scholar 

  • Ferrari CP, Dommergue A, Boutron CF, Skov H, Goodsite M, Jensen B (2004) Nighttime production of elemental gaseous mercury in interstitial air of snow at Station Nord, Greenland. Atmos Environ 38:2727–2735.

    CAS  Google Scholar 

  • Fitzgerald WF, Engstrom DR, Mason RP, Nater EA (1998) The case for atmospheric mercury contamination in remote areas. Environ Sci Technol 32:1–7.

    CAS  Google Scholar 

  • Foran JA, Hites RA, Carpenter DO, Hamilton MC, Mathews-Amos A, Schwager SJ . (2004)A survey of metals in tissues of farmed Atlantic and wild Pacific salmon Environ Toxicol Chem 23:2108–2110.

    CAS  Google Scholar 

  • Frery N, Maury-Brachet R, Maillot E, Deheeger M, de Merona B, Boudou A (2001) Gold-mining activities and mercury contamination of native Amerindian communities in French Guiana: Key role of fish in dietary uptake. Environ Health Perspect 109:449–456.

    CAS  Google Scholar 

  • Gao Y, Yan CH, Tian Y, Wang Y, Xie HF, Zhou X, Yu XD, Yu XG, Tong SL, Zhou QX, Shen XM (2007) Prenatal exposure to mercury and neurobehavioral development of neonates in Zhoushan City, China. Environ Res 105:390–399.

    CAS  Google Scholar 

  • Goering PL, Galloway WD, Clarkson TW, Lorscheider FL, Berlin M, Rowland AS (1992) Toxicity assessment of mercury-vapor from dental amalgams. Fundam Appl Toxicol 19:319–329.

    CAS  Google Scholar 

  • Grandjean P, Weihe P, Jorgensen PJ, Clarkson TW, Cernichiari E, Videro T (1992) Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health 47:185–195.

    CAS  Google Scholar 

  • Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ (1997) Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19:417–428.

    CAS  Google Scholar 

  • Grandjean P, White RF, Nielsen A, Cleary D, Santos ECD (1999) Methylmercury neurotoxicity in Amazonian children downstream from gold mining. Environ Health Perspect 107:587–591.

    CAS  Google Scholar 

  • Grandjean P, White RF, Weihe P (2004) Neurobehavioral epidemiology: Application in risk assessment. Environ Health Perspect 2:397–400.

    Google Scholar 

  • Hac E, Krzyzanowski M, Krechniak J (2000) Total mercury in human renal cortex, liver, cerebellum and hair. Sci Total Environ 248:37–43.

    CAS  Google Scholar 

  • Halsey NA (1999) Limiting infant exposure to thimerosal in vaccines and other sources of mercury. J Am Med Assoc 282:1763–1766.

    CAS  Google Scholar 

  • Hansen G, Victor R, Engeldinger E, Schweitzer C (2004) Evaluation of the mercury exposure of dental amalgam patients by the Mercury Triple Test. Occup Environ Med 61:535–540.

    CAS  Google Scholar 

  • Harada M (1995) Minamata disease—Methylmercury poisoning in Japan caused by environmental-pollution. Crit Rev Toxicol 25:1–24.

    CAS  Google Scholar 

  • Harada M, Nakanishi J, Konuma S, Ohno K, Kimura T, Yamaguchi H, Tsuruta K, Kizaki T, Ookawara T, Ohno H (1998) The present mercury contents of scalp hair and clinical symptoms in inhabitants of the Minamata area. Environ Res 77:160–164.

    CAS  Google Scholar 

  • Harada M, Nakachi S, Cheu T, Hamada H, Ono Y, Tsuda T, Yanagida K, Kizaki T, Ohno H (1999) Monitoring of mercury pollution in Tanzania: Relation between head hair mercury and health. Sci Total Environ 227:249–256.

    CAS  Google Scholar 

  • Harada M, Nakachi S, Tasaka K, Sakashita S, Muta K, Yanagida K, Doi R, Kizaki T, Ohno H (2001) Wide use of skin-lightening soap may cause mercury poisoning in Kenya. Sci Total Environ 269:183–187.

    CAS  Google Scholar 

  • Harakeh S, Sabra N, Kassak K, Doughan B (2002) Factors influencing total mercury levels among Lebanese dentists. Sci Total Environ 297:153–160.

    CAS  Google Scholar 

  • Harnly M, Seidel S, Rojas P, Fornes R, Flessel P, Smith D, Kreutzer R, Goldman L (1997) Biological monitoring for mercury within a community with soil and fish contamination. Environ Health Perspect 105:424–429.

    CAS  Google Scholar 

  • Hightower JM, Moore D (2003) Mercury levels in high-end consumers of fish. Environ Health Perspect 111:604–608.

    CAS  Google Scholar 

  • Holsbeek L, Das HK, Joiris CR (1996) Mercury in human hair and relation to fish consumption in Bangladesh. Sci Total Environ 186:181–188.

    CAS  Google Scholar 

  • IPCS (1990) Environmental Health Criteria 101. Methylmercury; World Health Organization, Geneva. http://www.inchem.org/documents/ehc/ehc/ehc101.htm.

  • Jaffe D, Prestbo E, Swartzendruber P, Weiss-Penzias P, Kato S, Takami A, Hatakeyama S, Kajii Y (2005) Export of atmospheric mercury from Asia. Atmos Environ 39:3029–3038.

    CAS  Google Scholar 

  • JECFA (Joint FAO/WHO (2006) Expert Committee on Food Additives) http://www.chem.unep.ch/mercury/Report/JECFA-PTWI.htm.

  • Kajiwara Y, Yasutake A, Adachi T, Hirayama K (1996) Methylmercury transport across the placenta via neutral amino acid carrier. Arch Toxicol 70:310–314.

    CAS  Google Scholar 

  • Kajiwara Y, Yasutake A, Hirayama K (1997) Strain difference in methylmercury transport across the placenta. Bull Environ Contam Toxicol 59:783–787.

    CAS  Google Scholar 

  • Kehrig HA, Malm O, Akagi H (1997) Methylmercury in hair samples from different riverine groups, Amazon, Brazil. Water Air Soil Pollut 97:17–29.

    CAS  Google Scholar 

  • Kerper LE, Ballatori N, Clarkson TW (1992) Methylmercury transport across the blood-brain-barrier by an amino-acid carrier. Am J Physiol 262:R761–R765.

    CAS  Google Scholar 

  • King JK, Kostka JE, Frischer ME, Saunders FM (2000) Sulfate-reducing bacteria methylate mercury at variable rates in pure culture and in marine sediments. Appl Environ Microbiol 66:2430–2437.

    CAS  Google Scholar 

  • Knobeloch L, Anderson HA, Imma P, Peters D, Smith A (2005) Fish consumption, advisory awareness, and hair mercury levels among women of childbearing age. Environ Res 97:220–227.

    CAS  Google Scholar 

  • Konig A, Bouzan C, Cohen JT, Connor WE, Kris-Etherton PM, Gray GM, Lawrence RS, Savitz DA, Teutsch SM (2005) A quantitative analysis of fish consumption and coronary heart disease mortality. Am J Prev Med 29:335–346.

    Google Scholar 

  • Kosatsky T, Przybysz R, Armstrong B (2000) Mercury exposure in Montrealers who eat St Lawrence River sportfish. Environ Res 84:36–43.

    CAS  Google Scholar 

  • Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, Erdman JW, Kris-Etherton P, Goldberg IJ, Kotchen TA, Lichtenstein AH, Mitch WE, Mullis R, Robinson K, Wylie-Rosett J, St Jeor S, Suttie J, Tribble DL, Bazzarre TL (2001) Revision 2000: A statement for healthcare professionals from the nutrition committee of the American Heart Association. J Nutr 131:132–146.

    CAS  Google Scholar 

  • Lamborg CH, Fitzgerald WF, O’Donnell J, Torgersen T (2002) A non-steady-state compartmental model of global-scale mercury biogeochemistry with interhemispheric atmospheric gradients. Geochim Cosmochim Acta 66:1105–1118.

    CAS  Google Scholar 

  • Lebel J, Roulet M, Mergler D, Lucotte M, Larribe F (1997) Fish diet and mercury exposure in a riparian Amazonian population. Water Air Soil Pollut 97:31–44.

    CAS  Google Scholar 

  • Lebel J, Mergler D, Branches F, Lucotte M, Amorim M, Larribe F, Dolbec J (1998) Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin. Environ Res 79:20–32.

    CAS  Google Scholar 

  • Lee WC, Lee MJ, Lee SM, Kim JS, Bae CS, Park TK (2000) An observation on the mercury contents of scalp hair in the urban residents of South Korea. Environ Toxicol Pharmacol 8:275–278.

    CAS  Google Scholar 

  • Legrand M, Lam R, Jensen-Fontaine M, Salin ED, Chan HM (2004) Direct detection of mercury in single human hair strands by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). J Anal Atom Spectrom 19:1287–1288.

    CAS  Google Scholar 

  • Legrand M, Lam R, Passos CJS, Mergler D, Salin ED, Chan HM (2007) Analysis of mercury in sequential micrometer segments of single hair strands of fish-eaters. Environ Sci Technol 41:593–598.

    CAS  Google Scholar 

  • Lindberg SE, Brooks S, Lin CJ, Scott KJ, Landis MS, Stevens RK, Goodsite M, Richter A (2002) Dynamic oxidation of gaseous mercury in the Arctic troposphere at polar sunrise. Environ Sci Technol 36:1245–1256.

    CAS  Google Scholar 

  • Lindberg A, Bjornberg KA, Vahter M, Berglund M (2004) Exposure to methylmercury in non-fish-eating people in Sweden. Environ Res 96:28–33.

    CAS  Google Scholar 

  • Mahaffey KR, Clickner RP, Bodurow CC (2004) Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ Health Perspect 112:562–570.

    CAS  Google Scholar 

  • Makrides M, Neuman M, Simmer K, Pater J, Gibson R (1995) Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet 345:1463–1468.

    CAS  Google Scholar 

  • Malm O (1998) Gold mining as a source of mercury exposure in the Brazilian Amazon. Environ Res 77:73–78.

    CAS  Google Scholar 

  • Malm O, Branches FJP, Akagi H, Castro MB, Pfeiffer WC, Harada M, Bastos WR, Kato H (1995) Mercury and methylmercury in fish and human hair from the Tapajos river basin, Brazil. Sci Total Environ 175:141–150.

    CAS  Google Scholar 

  • Mason RP, Fitzgerald WF, Morel FMM (1994) The biogeochemical cycling of elemental mercury—Anthropogenic influences. Geochim Cosmochim Acta 58:3191–3198.

    CAS  Google Scholar 

  • McDowell MA, Dillon CF, Osterloh J, Bolger PM, Pellizzari E, Fernando R, de Oca RM, Schober SE, Sinks T, Jones RL, Mahaffey KR (2004) Hair mercury levels in US children and women of childbearing age: Reference range data from NHANES 1999–2000. Environ Health Perspect 112:1165–1171.

    CAS  Google Scholar 

  • McMichael AJ, Butler CD (2005) Fish, health, and sustainability. Am J Prev Med 29:322–323.

    Google Scholar 

  • Mendola P, Selevan SG, Gutter S, Rice D (2002) Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment Retard Dev Disabil Res Rev 8:188–197.

    Google Scholar 

  • Montuori P, Jover E, Alzaga R, Díez S, Bayona JM (2004) Improvements in the methylmercury extraction from human hair by headspace solid-phase microextraction followed by gas-chromatography cold-vapour atomic fluorescence spectrometry. J Chromatogr A 1025:71–75.

    CAS  Google Scholar 

  • Montuori P, Jover E, Díez S, Ribas-Fito N, Sunyer J, Triassi M, Bayona JM (2006) Mercury speciation in the hair of pre-school children living near a chlor-alkali plant. Sci Total Environ 369:51–58.

    CAS  Google Scholar 

  • Mortada WI, Sobh MA, El-Defrawy MM, Farahat SE (2002) Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among residents in Mansoura city, Nile Delta, Egypt. Environ Res 90:104–110.

    CAS  Google Scholar 

  • Morton J, Mason HJ, Ritchie KA, White M (2004) Comparison of hair, nails and urine for biological monitoring of low level inorganic mercury exposure in dental workers. Biomarkers 9:47–55.

    CAS  Google Scholar 

  • Muckle G, Ayotte P, Dewailly E, Jacobson SW, Jacobson JL (2001) Prenatal exposure of the Northern Quebec iuit infants to environmental contaminants. Environ Health Perspect 109:1291–1299.

    CAS  Google Scholar 

  • Murata K, Budtz-Jorgensen E, Grandjean P (2002) Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children. Risk Anal 22:465–474.

    Google Scholar 

  • Murata K, Sakamoto M, Nakai K, Weihe P, Dakeishi M, Iwata T, Liu X J, Ohno T, Kurosawa T, Kamiya K, Satoh H (2004) Effects of methylmercury on neurodevelopment in Japanese children in relation to the Madeiran study. Int Arch Occup Environ Health 77:571–579.

    CAS  Google Scholar 

  • Myers GJ, Davidson PW, Shamlaye CF, Axtell CD, Cernichiari E, Choisy O, Choi A, Cox C, Clarkson TW (1997) Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study. Neurotoxicol 18:819–829.

    CAS  Google Scholar 

  • Myers GJ, Davidson PW, Cox C, Shamlaye C, Cernichiari E, Clarkson TW (2000) Twenty-seven years studying the human neurotoxicity of methylmercury exposure. Environ Res 83:275–285.

    CAS  Google Scholar 

  • Nakagawa, R (1995) Concentration of mercury in hair of Japanese people. Chemosphere 30:127–133.

    CAS  Google Scholar 

  • NRC (2000) Toxicological effects of methylmercury. National Research Council, National Academy Press, Washington, DC.

    Google Scholar 

  • Oken E, Wright RO, Kleinman KP, Bellinger D, Amarasiriwardena CJ, Hu, H, Rich-Edwards JW, Gillman MW (2005) Maternal fish consumption, hair mercury, and infant cognition in a US cohort. Environ Health Perspect 113:1376–1380.

    CAS  Google Scholar 

  • Olivero J, Johnson B, Arguello E (2002) Human exposure to mercury in San Jorge river basin, Colombia (South America). Sci Total Environ 289:41–47.

    CAS  Google Scholar 

  • Phelps RW, Clarkson TW, Kershaw TG, Wheatley B (1980) Interrelationships of blood and hair mercury concentrations in a North-American population exposed to methylmercury. Arch Environ Health 35:161–168.

    CAS  Google Scholar 

  • Pesch A, Wilhelm M, Rostek U, Schmitz N, Weishoff-Houben M, Ranft U, Idel H (2002) Mercury concentrations in urine, scalp hair, and saliva in children from Germany. J Exp Anal Environ Epidemiol 12:252–258.

    CAS  Google Scholar 

  • Razagui IBA, HaswellSJ (2001) Mercury and selenium concentrations in maternal and neonatal scalp hair—Relationship to amalgam-based dental treatment received during pregnancy. Biol Trace Elem Res 81:1–19.

    CAS  Google Scholar 

  • Renzoni A, Zino F, Franchi E (1998) Mercury levels along the food chain and risk for exposed populations. Environ Res 77:68–72.

    CAS  Google Scholar 

  • Rowland I, Davies M, Grasso P (1977) Biosynthesis of methylmercury compounds by intestinal flora of rat. Arch Environ Health 32:24–28.

    CAS  Google Scholar 

  • Saeki K, Fujimoto M, Kolinjim D, Tatsukawa R (1996) Mercury concentrations in hair from populations in Wau-Bulolo area, Papua New Guinea. Arch Environ Contam Toxicol 30:412–417.

    CAS  Google Scholar 

  • Sager PR (2006)Mercury levels in Argentine newborns and infants after receipt of routine vaccines containing thimerosal. Neurotoxicol Teratol 28:426–426.

    Google Scholar 

  • Sakamoto M, Kakita A, Wakabayashi K, Takahashi H, Nakano A, Akagi H (2002) Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: A study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res 949:51–59.

    CAS  Google Scholar 

  • Sakamoto M, Kubota M, Liu XH, Murata K, Nakai K, Satoh H (2004) Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus. Environ Sci Technol 38:3860–3863.

    CAS  Google Scholar 

  • Santos ECO, Camara VMJesus IM, Brabo ES, Loureiro ECB, Mascarenhas AFS, Fayal KF, Sa GC, Sagica FES, Lima MO, Higuchi H, Silveira IM (2002a) A contribution to the establishment of reference values for total mercury levels in hair and fish in Amazonia. Environ Res 90:6–11.

    CAS  Google Scholar 

  • Santos ECO, JesusIM, Camara VM, Brabo E, Loureiro ECB, Mascarenhas A, Weirich J, Luiz RR, Cleary D (2002b) Mercury exposure in Munduruku Indians from the community of Sai Cinza, State of Para, Brazil. Environ Res 90:98–103.

    Google Scholar 

  • Schroeder WH, Anlauf KG, Barrie LA, Lu JY, Steffen A, Schneeberger DR, Berg T (1998) Arctic springtime depletion of mercury. Nature 394:331–332.

    CAS  Google Scholar 

  • Skerrett PJ, Hennekens CH (2003) Consumption of fish and fish oils and decreased risk of stroke. Prev Cardiol 6:38–41.

    CAS  Google Scholar 

  • Smith JC, Farris FF (1996) Methyl mercury pharmacokinetics in man: A reevaluation. Toxicol Appl Pharmacol 137:245–252.

    CAS  Google Scholar 

  • Stern AH, Gochfeld M, Weisel C, Burger J (2001) Mercury and methylmercury exposure in the New Jersey pregnant population. Arch Environ Health 56:4–10.

    CAS  Google Scholar 

  • Stern AH, Smith AE (2003) An assessment of the cord blood: Maternal blood methylmercury ratio: Implications for risk assessment. Environ Health Perspect 111:1465–1470.

    CAS  Google Scholar 

  • Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, Budtz-Jorgensen E, Grandjean P (2000) Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr 136:599–605.

    CAS  Google Scholar 

  • Teutsch SM, Cohen JT (2005) Health trade-offs from policies to alter fish consumption. Am J Prev Med 29:324–324.

    Google Scholar 

  • Toribara TY (2001) Analysis of single hair by XRF discloses mercury intake. Hum Exp Toxicol 20:185–188.

    CAS  Google Scholar 

  • Travnikov O (2005) Contribution of the intercontinental atmospheric transport to mercury pollution in the Northern Hemisphere. Atmos Environ 39:7541–7548.

    CAS  Google Scholar 

  • Tsubaki T, Irukayama K (1977) Minamata Disease: Methylmercury Poisoning in Minamata and Niigata, Japan. Elsevier.New York:

    Google Scholar 

  • USEPA (1997) Mercury Study Report to Congress. Office of Air Quality Planning and Standards and Office of Research and Development, EPA 452/R-97-0003, Washington, DC.

    Google Scholar 

  • USEPA (2001) Water Quality Criterion for the Protection of Human Health: Methyl Mercury. EPA 0823-R-01-001. Washington, DC.

    Google Scholar 

  • Vahter M, Akesson A, Lind B, Bjors U, Schutz A, Berglund M (2000) Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ Res 84:186–194.

    CAS  Google Scholar 

  • Van Oostdam J, Gilman A, Dewailly E, Usher P, Wheatley B, Kuhnlein H, Neve S, Walker J, Tracy B, Feeley M, Jerome V, Kwavnick B (1999) Human health implications of environmental contaminants in Arctic Canada: A review. Sci Total Environ 230:1–82.

    CAS  Google Scholar 

  • Watras CJ, Morrison KA, Kent A, Price N, Regnell O, Eckley C, Hintelmann H, Hubacher T (2005) Sources of methylmercury to a wetland-dominated lake in northern Wisconsin. Environ Sci Technol 39:4747–4758.

    CAS  Google Scholar 

  • Wong CSC, Duzgoren-Aydin NS, AydinA, Wong MH (2006)Sources and trends of environmental mercury emissions in Asia. Sci Total Environ 368:649–662.

    CAS  Google Scholar 

  • Wong CSC, Duzgoren-Aydin NS, AydinA, Wong MH (2006)Sources and trends of environmental mercury emissions in Asia. Sci Total Environ 368:649–662.

    CAS  Google Scholar 

  • Yasutake A, Matsumoto M, Yamaguchi M, Hachiya N (2003) Current hair mercury levels in Japanese: Survey in five districts. Tohoku J Exp Med 199:161–169.

    CAS  Google Scholar 

  • Yasutake A, Matsumoto M, Yamaguchi M, Hachiya N (2004) Current hair mercury levels in Japanese for estimation of methylmercury exposure. J Health Sci 50:120–125.

    CAS  Google Scholar 

  • Yavin E, Glozman S, Green P (2001) Docosahexaenoic acid sources for the developing brain during intrauterine life. Nutr Health 15:219–224.

    CAS  Google Scholar 

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  1. Environmental Chemistry Department, IDAEA-CSIC, Jordi Girona, 18–26, E-08034, Barcelona, Spain

    Sergi Díez

  2. Environmental Geology Department, ICTJA-CSIC, Lluis Solé i Sabarís, s/n, E-08028 Barcelona, Spain

    Sergi Díez

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Díez, S. (2008). Human Health Effects of Methylmercury Exposure. In: Whitacre, D.M. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 198. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09647-6_3

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