Abstract
Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models incorporating genetic and environmental manipulations have been employed for preclinical testing of hypothesis-driven pharmacological targets, to begin to develop treatments for the diagnostic and associated symptoms of autism. In this review, we summarize rodent behavioral assays relevant to the core features of autism, preclinical and clinical evaluations of pharmacological interventions, and strategies to improve the translational value of rodent models of autism.
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Acknowledgments
This work was supported by the MIND Institute Autism Research Training Program MH0073124 (TK), Autism Speaks Targeted Award #8703 (JC, JS) NINDS 1R01NS085709 (JC, PL), the MIND Institute Intellectual and Developmental Disabilities Research Center 1U54HD079125, and NIMH 1R01 MH103284 (MS).
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Kazdoba, T.M., Leach, P.T., Yang, M., Silverman, J.L., Solomon, M., Crawley, J.N. (2015). Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics. In: Robbins, T.W., Sahakian, B.J. (eds) Translational Neuropsychopharmacology. Current Topics in Behavioral Neurosciences, vol 28. Springer, Cham. https://doi.org/10.1007/7854_2015_5003
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