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Antimicrobial Activity of Xibornol and a Xibornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract

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Advances in Microbiology, Infectious Diseases and Public Health

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 1369))

Abstract

Xibornol is known since the 70s and a xibornol-based formulation is commercialized as spray suspension for the antisepsis of the oral cavity and as adjuvant in pharyngeal infections caused by Gram-positive microorganisms. Herein, we evaluated the antimicrobial activity of xibornol and the xibornol-based formulation against common pathogens of the upper and lower respiratory tract.

Our results indicate that xibornol alone and the xibornol-based formulation have strong antibacterial action against Streptococcus pneumoniae, Streptococcus pyogenes, and Staphyloccus aureus, as well as against the two emerging pathogens Actinomyces israelii and Corynebacterium ulcerans. These findings highlight the antimicrobial potential of these drugs in the topical control of pathogenic Gram-positive bacteria of the respiratory tract.

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Funding

This work received a grant from Abiogen Pharma S.p.a.

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Authors and Affiliations

  1. Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Francesco Celandroni, Diletta Mazzantini, Marco Calvigioni & Emilia Ghelardi

  2. Abiogen Pharma, Pisa, Italy

    Stefano Ceccanti, Sandra Vecchiani, Santina Battaglia & Cristina Bigini

  3. Research Center Nutraceuticals and Food for Health-Nutrafood, University of Pisa, Pisa, Italy

    Emilia Ghelardi

Authors
  1. Francesco Celandroni
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  2. Diletta Mazzantini
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  3. Marco Calvigioni
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  4. Stefano Ceccanti
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  5. Sandra Vecchiani
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  6. Santina Battaglia
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  7. Cristina Bigini
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  8. Emilia Ghelardi
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Corresponding author

Correspondence to Francesco Celandroni .

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Editors and Affiliations

  1. Microbial Biofilm Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy

    Gianfranco Donelli

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Celandroni, F. et al. (2021). Antimicrobial Activity of Xibornol and a Xibornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract. In: Donelli, G. (eds) Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology(), vol 1369. Springer, Cham. https://doi.org/10.1007/5584_2021_664

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