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Free-Radical-Induced DNA Damage and Its Repair

A Chemical Perspective

  • Book
  • © 2006

Overview

Authors:
  1. Clemens Sonntag

    1. Mühlheim, Germany

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  • Provides an invaluable reference tool for the study of free radical-induced DNA damage and its repair, balancing the chemical and molecular approaches

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-XX
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  2. Introduction

    Pages 1-5

  3. Formation of Reactive Free Radicals in an Aqueous Environment

    Pages 7-46

  4. The Hydroxyl Radical

    Pages 47-75

  5. Hydrogen Atom and Hydrated Electron

    Pages 77-86

  6. Inorganic Radicals

    Pages 87-99

  7. Carbon-Centered Radicals

    Pages 101-134

  8. Heteroatom-Centered Radicals

    Pages 135-158

  9. Peroxyl Radicals

    Pages 159-194

  10. Polymer Radicals

    Pages 195-210

  11. Nucleobases, Nucleosides and Nucleotides

    Pages 211-334

  12. Polynucleotides and Single-Stranded DNA Fragments

    Pages 335-355

  13. DNA and Double-Stranded Oligonucleotides

    Pages 357-482

  14. Methods

    Pages 483-504

  15. Back Matter

    Pages 505-523
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Keywords

About this book

The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.

Authors and Affiliations

  • Mühlheim, Germany

    Clemens Sonntag

About the author

Born in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut für Strahlenchemie, Mülheim. After retirement continuing collaboration with the Leibniz-Institut für Oberflächenmodifizierung (IOM), Leipzig.

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