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Allergic Diseases – From Basic Mechanisms to Comprehensive Management and Prevention pp 43–52Cite as

Cutaneous Barriers and Skin Immunity

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 268))

Abstract

The skin barrier provides us with several lines of protection from outside hazards. Its most outward layers, the stratum corneum and the epidermis seal our body with an acidic, dry, and rather cool surface, hostile to microbes. Yet, there are also fine-tuned interactions between the mostly commensal microbiota on top of the skin surface, with underlying epidermal cells as well as the immune system, to preserve a healthy steady state and to initiate repair processes when necessary. We take a concise look at the recent insights on the inner workings of this complex barrier.

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Author information

Authors and Affiliations

  1. Department of Dermatology and Allergy, School of Medicine, Technical University Munich, Munich, Germany

    Martin Köberle, Yacine Amar, Inga Marie Hölge, Susanne Kaesler & Tilo Biedermann

  2. Clinical Unit Allergology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany

    Tilo Biedermann

Authors
  1. Martin Köberle
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  2. Yacine Amar
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  3. Inga Marie Hölge
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  4. Susanne Kaesler
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  5. Tilo Biedermann
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Corresponding author

Correspondence to Tilo Biedermann .

Editor information

Editors and Affiliations

  1. Department of Environmental Medicine, University Augsburg, Medical Faculty, Augsburg, Germany

    Claudia Traidl-Hoffmann

  2. Charité - Universitätsmedizin Berlin, Klinik für Dermatologie, Berlin, Berlin, Germany

    Torsten Zuberbier

  3. Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hanover, Germany

    Thomas Werfel

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Köberle, M., Amar, Y., Hölge, I.M., Kaesler, S., Biedermann, T. (2021). Cutaneous Barriers and Skin Immunity. In: Traidl-Hoffmann, C., Zuberbier, T., Werfel, T. (eds) Allergic Diseases – From Basic Mechanisms to Comprehensive Management and Prevention . Handbook of Experimental Pharmacology, vol 268. Springer, Cham. https://doi.org/10.1007/164_2021_477

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