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Packed Bed Bioreactors

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Bioreactors for Tissue Engineering

Summary

Packed bed bioreactors are a promising tool for tissue engineering applications that have not been fully utilised to date. They are capable of supporting various cell lines for long culture periods under low shear conditions, due to the immobilisation of cells within macroporous matrices. Various configurations have been designed that deal with the problems traditionally associated with immobilised cell cultures, such as non-ideal fluid flow and mass transport limitations. These have enabled good scale-up and superior productivity to alternative systems such as hollow-fibre reactors. Packed bed reactors are currently being employed in studies to develop bioartificial liver support systems (Morsiani et al. 2000; Shiba et al. 2003) but have also been used for the ex vivo expansion of bone marrow cells (Highfill et al. 1996).

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  1. Department of Chemical Engineering, University of Birmingham, Birmingham, UK

    J. N. Warnock, K. Bratch & M. Al-Rubeai

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  1. J. N. Warnock
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  2. K. Bratch
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Editors and Affiliations

  1. University of Bath, UK

    Julian Chaudhuri

  2. University College Dublin, Ireland

    Mohamed Al-Rubeai

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Warnock, J.N., Bratch, K., Al-Rubeai, M. (2005). Packed Bed Bioreactors. In: Chaudhuri, J., Al-Rubeai, M. (eds) Bioreactors for Tissue Engineering. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3741-4_4

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